6dd3 - Revision history

OCA at 14:33, 13 March 2024

2024-03-13T14:33:47Z

←Older revision		Revision as of 14:33, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>NT5C2, NT5B, NT5CP, PNT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [https://pdbe.org/6dd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [~~http~~://pdbe.org/6dd3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>	+	[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.	+	[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Activating mutations in the cytosolic 5'-nucleotidase II gene NT5C2 drive resistance to 6-mercaptopurine in acute lymphoblastic leukemia. Here we demonstrate that constitutively active NT5C2 mutations K359Q and L375F reconfigure the catalytic center for substrate access and catalysis in the absence of allosteric activator. In contrast, most relapse-associated mutations, which involve the arm segment and residues along the surface of the inter-monomeric cavity, disrupt a built-in switch-off mechanism responsible for turning off NT5C2. In addition, we show that the C-terminal acidic tail lost in the Q523X mutation functions to restrain NT5C2 activation. These results uncover dynamic mechanisms of enzyme regulation targeted by chemotherapy resistance-driving NT5C2 mutations, with important implications for the development of NT5C2 inhibitor therapies.	+
-		+
-	Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.,Dieck CL, Tzoneva G, Forouhar F, Carpenter Z, Ambesi-Impiombato A, Sanchez-Martin M, Kirschner-Schwabe R, Lew S, Seetharaman J, Tong L, Ferrando AA Cancer Cell. 2018 Jul 9;34(1):136-147.e6. doi: 10.1016/j.ccell.2018.06.003. PMID:29990496<ref>PMID:29990496</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6dd3" style="background-color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~5'-nucleotidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ambesi-Impiombato, A]]	+	[[Category: Ambesi-Impiombato A]]
-	[[Category: Carpenter, Z]]	+	[[Category: Carpenter Z]]
-	[[Category: Dieck~~, C L~~]]	+	[[Category: Dieck CL]]
-	[[Category: Ferrando~~, A A~~]]	+	[[Category: Ferrando AA]]
-	[[Category: Forouhar, F]]	+	[[Category: Forouhar F]]
-	[[Category: Kirschner-Schwabe, R]]	+	[[Category: Kirschner-Schwabe R]]
-	[[Category: Lew, S]]	+	[[Category: Lew S]]
-	[[Category: Sanchez-Martin, M]]	+	[[Category: Sanchez-Martin M]]
-	[[Category: Seetharaman, J]]	+	[[Category: Seetharaman J]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	[[Category: Tzoneva, G]]	+	[[Category: Tzoneva G]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:04, 4 December 2019

2019-12-04T10:04:40Z

←Older revision		Revision as of 10:04, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state==		==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state==
-	<StructureSection load='6dd3' size='340' side='right' caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>
Line 28:		Line 28:
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ambesi-Impiombato, A]]		[[Category: Ambesi-Impiombato, A]]
	[[Category: Carpenter, Z]]		[[Category: Carpenter, Z]]

OCA at 07:36, 25 July 2018

2018-07-25T07:36:39Z

←Older revision		Revision as of 07:36, 25 July 2018
Line 3:		Line 3:
	<StructureSection load='6dd3' size='340' side='right' caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='6dd3' size='340' side='right' caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NT5C2, NT5B, NT5CP, PNT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [http://pdbe.org/6dd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [http://pdbe.org/6dd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr>
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.		[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activating mutations in the cytosolic 5'-nucleotidase II gene NT5C2 drive resistance to 6-mercaptopurine in acute lymphoblastic leukemia. Here we demonstrate that constitutively active NT5C2 mutations K359Q and L375F reconfigure the catalytic center for substrate access and catalysis in the absence of allosteric activator. In contrast, most relapse-associated mutations, which involve the arm segment and residues along the surface of the inter-monomeric cavity, disrupt a built-in switch-off mechanism responsible for turning off NT5C2. In addition, we show that the C-terminal acidic tail lost in the Q523X mutation functions to restrain NT5C2 activation. These results uncover dynamic mechanisms of enzyme regulation targeted by chemotherapy resistance-driving NT5C2 mutations, with important implications for the development of NT5C2 inhibitor therapies.
		+
		+	Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.,Dieck CL, Tzoneva G, Forouhar F, Carpenter Z, Ambesi-Impiombato A, Sanchez-Martin M, Kirschner-Schwabe R, Lew S, Seetharaman J, Tong L, Ferrando AA Cancer Cell. 2018 Jul 9;34(1):136-147.e6. doi: 10.1016/j.ccell.2018.06.003. PMID:29990496<ref>PMID:29990496</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dd3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
		+	[[Category: Human]]
	[[Category: Ambesi-Impiombato, A]]		[[Category: Ambesi-Impiombato, A]]
	[[Category: Carpenter, Z]]		[[Category: Carpenter, Z]]

OCA at 07:15, 4 July 2018

2018-07-04T07:15:07Z

←Older revision		Revision as of 07:15, 4 July 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dd3 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state==
-		+	<StructureSection load='6dd3' size='340' side='right' caption='[[6dd3]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors~~: ~~Forouhar, F~~.~~, Dieck, C~~.L.~~, Tzoneva, G~~.~~, Carpenter, Z~~.~~, Ambesi~~-~~Impiombato, A~~., ~~Sanchez~~-~~Martin~~, M.~~, Kirschner~~-~~Schwabe~~, R., ~~Lew, S~~., ~~Seetharaman, J~~.~~, Ferrando, A~~.A., ~~Tong~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD3 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of~~ the ~~double mutant (D52N~~/~~D407A) of NT5C2-537X~~ in the ~~active state~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [http://pdbe.org/6dd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 5'-nucleotidase]]
		+	[[Category: Ambesi-Impiombato, A]]
	[[Category: Carpenter, Z]]		[[Category: Carpenter, Z]]
		+	[[Category: Dieck, C L]]
		+	[[Category: Ferrando, A A]]
	[[Category: Forouhar, F]]		[[Category: Forouhar, F]]
		+	[[Category: Kirschner-Schwabe, R]]
	[[Category: Lew, S]]		[[Category: Lew, S]]
		+	[[Category: Sanchez-Martin, M]]
		+	[[Category: Seetharaman, J]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
-	[[Category: Kirschner-Schwabe, R]]
-	[[Category: Ferrando, A.A]]
-	[[Category: Sanchez-Martin, M]]
	[[Category: Tzoneva, G]]		[[Category: Tzoneva, G]]
-	[[Category: ~~Dieck, C.L]]~~	+	[[Category: Hydrolase]]
-	~~[[Category: Ambesi-Impiombato, A]]~~	+
-	~~[[Category: Seetharaman, J~~]]	+

OCA at 04:15, 6 June 2018

2018-06-06T04:15:46Z

←Older revision		Revision as of 04:15, 6 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dd3 is ON HOLD	+	The entry 6dd3 is ON HOLD until Paper Publication

-	Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J~~., Tong, L~~., Ferrando, A.A., ~~Northeast Structural Genomics Consortium (NESG)~~	+	Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Ferrando, A.A., Tong, L.

	Description: Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state		Description: Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Northeast Structural Genomics Consortium (Nesg)]]
-	[[Category: Kirschner-Schwabe, R]]
-	[[Category: Ferrando, A.A]]
-	[[Category: Tzoneva, G]]
-	[[Category: Dieck, C.L]]
	[[Category: Carpenter, Z]]		[[Category: Carpenter, Z]]
	[[Category: Forouhar, F]]		[[Category: Forouhar, F]]
		+	[[Category: Lew, S]]
	[[Category: Tong, L]]		[[Category: Tong, L]]
		+	[[Category: Kirschner-Schwabe, R]]
		+	[[Category: Ferrando, A.A]]
	[[Category: Sanchez-Martin, M]]		[[Category: Sanchez-Martin, M]]
-	[[Category: ~~Lew~~, S]]	+	[[Category: Tzoneva, G]]
		+	[[Category: Dieck, C.L]]
	[[Category: Ambesi-Impiombato, A]]		[[Category: Ambesi-Impiombato, A]]
	[[Category: Seetharaman, J]]		[[Category: Seetharaman, J]]

OCA: Protected "6dd3" [edit=sysop:move=sysop]

2018-05-16T04:08:28Z

Protected "6dd3" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dd3 is ON HOLD Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Le...

2018-05-16T04:08:27Z

New page: '''Unreleased structure''' The entry 6dd3 is ON HOLD Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Le...

New page

'''Unreleased structure'''

The entry 6dd3 is ON HOLD

Authors: Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Tong, L., Ferrando, A.A., Northeast Structural Genomics Consortium (NESG)

Description: Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
[[Category: Unreleased Structures]]
[[Category: Northeast Structural Genomics Consortium (Nesg)]]
[[Category: Kirschner-Schwabe, R]]
[[Category: Ferrando, A.A]]
[[Category: Tzoneva, G]]
[[Category: Dieck, C.L]]
[[Category: Carpenter, Z]]
[[Category: Forouhar, F]]
[[Category: Tong, L]]
[[Category: Sanchez-Martin, M]]
[[Category: Lew, S]]
[[Category: Ambesi-Impiombato, A]]
[[Category: Seetharaman, J]]