6dd9 - Revision history

OCA at 06:03, 11 October 2023

2023-10-11T06:03:27Z

←Older revision		Revision as of 06:03, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6dd9' size='340' side='right'caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6dd9' size='340' side='right'caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6dd8\|6dd8]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Sycp3, mCG_16771 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd9 OCA], [https://pdbe.org/6dd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dd9 RCSB], [https://www.ebi.ac.uk/pdbsum/6dd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd9 OCA], [~~http~~://pdbe.org/6dd9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dd9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dd9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd9 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYCP3_MOUSE SYCP3_MOUSE] Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:11311943, PubMed:22761579). Required for centromere pairing during meiosis in male germ cells (PubMed:22761579). Required for normal meiosis during spermatogenesis and male fertility (PubMed:10678170). Plays a lesser role in female fertility (PubMed:10678170, PubMed:12004129). Required for efficient phosphorylation of HORMAD1 and HORMAD2 (PubMed:22346761).<ref>PMID:10678170</ref> <ref>PMID:11311943</ref> <ref>PMID:12004129</ref> <ref>PMID:22346761</ref> <ref>PMID:22761579</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Corbett~~, K D~~]]	+	[[Category: Corbett KD]]
-	[[Category: Munoz~~, I C~~]]	+	[[Category: Munoz IC]]
-	[[Category: Rosenberg~~, S C~~]]	+	[[Category: Rosenberg SC]]
-	[[Category: Uson, I]]	+	[[Category: Uson I]]
-	~~[[Category: Chromosome axis]]~~	+
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Meiosis]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 11:00, 1 January 2020

2020-01-01T11:00:18Z

←Older revision		Revision as of 11:00, 1 January 2020
Line 1:		Line 1:

	==Structure of mouse SYCP3, P1 form==		==Structure of mouse SYCP3, P1 form==
-	<StructureSection load='6dd9' size='340' side='right' caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='6dd9' size='340' side='right'caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Corbett, K D]]		[[Category: Corbett, K D]]

OCA at 08:35, 21 February 2019

2019-02-21T08:35:42Z

←Older revision		Revision as of 08:35, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='6dd9' size='340' side='right' caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6dd9' size='340' side='right' caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dd8\|6dd8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dd8\|6dd8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sycp3, mCG_16771 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd9 OCA], [http://pdbe.org/6dd9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd9 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd9 OCA], [http://pdbe.org/6dd9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd9 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that 'axis core proteins' from budding yeast (Red1), mammals (SYCP2/SYCP3), and plants (ASY3/ASY4) are evolutionarily related and play equivalent roles in chromosome axis assembly. We first identify 'closure motifs' in each complex that recruit meiotic HORMADs, the master regulators of meiotic recombination. We next find that axis core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2:SYCP3 and ASY3:ASY4) coiled-coil assemblies that further oligomerize into micron-length filaments. Thus, the meiotic chromosome axis core in fungi, mammals, and plants shares a common molecular architecture, and likely also plays conserved roles in meiotic chromosome axis assembly and recombination control.
		+
		+	A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.,West AM, Rosenberg SC, Ur SN, Lehmer MK, Ye Q, Hagemann G, Caballero I, Uson I, MacQueen AJ, Herzog F, Corbett KD Elife. 2019 Jan 18;8. pii: 40372. doi: 10.7554/eLife.40372. PMID:30657449<ref>PMID:30657449</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dd9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Corbett, K D]]		[[Category: Corbett, K D]]
	[[Category: Munoz, I C]]		[[Category: Munoz, I C]]

OCA at 18:50, 1 August 2018

2018-08-01T18:50:16Z

←Older revision		Revision as of 18:50, 1 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dd9 is ~~ON HOLD until Paper Publication~~	+	==Structure of mouse SYCP3, P1 form==
-		+	<StructureSection load='6dd9' size='340' side='right' caption='[[6dd9]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dd9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DD9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dd8\|6dd8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd9 OCA], [http://pdbe.org/6dd9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dd9 RCSB], [http://www.ebi.ac.uk/pdbsum/6dd9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd9 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Corbett, K D]]
		+	[[Category: Munoz, I C]]
		+	[[Category: Rosenberg, S C]]
		+	[[Category: Uson, I]]
		+	[[Category: Chromosome axis]]
		+	[[Category: Coiled-coil]]
		+	[[Category: Meiosis]]
		+	[[Category: Structural protein]]

OCA at 04:03, 30 May 2018

2018-05-30T04:03:43Z

←Older revision		Revision as of 04:03, 30 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dd9 is ON HOLD	+	The entry 6dd9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dd9" [edit=sysop:move=sysop]

2018-05-16T04:09:18Z

Protected "6dd9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:09, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dd9 is ON HOLD Authors: Description: Category: Unreleased Structures

2018-05-16T04:09:16Z

New page: '''Unreleased structure''' The entry 6dd9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dd9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]