6deb - Revision history

OCA at 06:04, 11 October 2023

2023-10-11T06:04:27Z

←Older revision		Revision as of 06:04, 11 October 2023
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	<StructureSection load='6deb' size='340' side='right'caption='[[6deb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6deb' size='340' side='right'caption='[[6deb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6deb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camje Camje~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6deb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DEB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folD, Cj0855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192222 CAMJE])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deb OCA], [~~http~~://pdbe.org/6deb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6deb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6deb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6deb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deb OCA], [https://pdbe.org/6deb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6deb RCSB], [https://www.ebi.ac.uk/pdbsum/6deb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6deb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FOLD_CAMJE FOLD_CAMJE]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]	+	[https://www.uniprot.org/uniprot/FOLD_CAMJE FOLD_CAMJE] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camje~~]]	+	[[Category: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Grimshaw S]]
-	[[Category: Grimshaw, S]]	+	[[Category: Joachimiak A]]
-	[[Category: Joachimiak, A]]	+	[[Category: Kim Y]]
-	[[Category: Kim, Y]]	+	[[Category: Makowska-Grzyska M]]
-	[[Category: Makowska-Grzyska, M]]	+	[[Category: Maltseva N]]
-	[[Category: Maltseva, N]]	+
-	~~[[Category: Alpha-beta-fold]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Mthfdc]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:06, 18 December 2019

2019-12-18T10:06:22Z

←Older revision		Revision as of 10:06, 18 December 2019
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	==Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase in the Complex with Methotrexate from Campylobacter jejuni==		==Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase in the Complex with Methotrexate from Campylobacter jejuni==
-	<StructureSection load='6deb' size='340' side='right' caption='[[6deb]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='6deb' size='340' side='right'caption='[[6deb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6deb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6deb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camje Camje]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folD, Cj0855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192222 CAMJE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deb OCA], [http://pdbe.org/6deb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6deb RCSB], [http://www.ebi.ac.uk/pdbsum/6deb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6deb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deb OCA], [http://pdbe.org/6deb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6deb RCSB], [http://www.ebi.ac.uk/pdbsum/6deb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6deb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camje]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Grimshaw, S]]		[[Category: Grimshaw, S]]

OCA: Protected "6deb" [edit=sysop:move=sysop]

2018-05-23T07:27:55Z

Protected "6deb" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:27, 23 May 2018

OCA: New page: ==Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase in the Complex with Methotrexate from Campylobacter jejuni==
2018-05-23T07:27:53Z

New page: ==Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase in the Complex with Methotrexate from Campylobacter jejuni== <StructureSection load=...

New page

==Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase in the Complex with Methotrexate from Campylobacter jejuni==
<StructureSection load='6deb' size='340' side='right' caption='[[6deb]], [[Resolution|resolution]] 1.70Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6deb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deb OCA], [http://pdbe.org/6deb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6deb RCSB], [http://www.ebi.ac.uk/pdbsum/6deb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6deb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FOLD_CAMJE FOLD_CAMJE]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
TOC
</StructureSection>
[[Category: Structural genomic]]
[[Category: Grimshaw, S]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Maltseva, N]]
[[Category: Alpha-beta-fold]]
[[Category: Csgid]]
[[Category: Mthfdc]]
[[Category: Oxidoreductase]]