6def - Revision history

OCA at 06:04, 11 October 2023

2023-10-11T06:04:34Z

←Older revision		Revision as of 06:04, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6def' size='340' side='right'caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='6def' size='340' side='right'caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6def]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chatd Chatd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DEF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6def]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DEF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene~~>, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CTHT_0061810 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=759272 CHATD])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6def OCA], [~~http~~://pdbe.org/6def PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6def RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6def PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6def ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6def OCA], [https://pdbe.org/6def PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6def RCSB], [https://www.ebi.ac.uk/pdbsum/6def PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6def ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0SFF0_CHATD G0SFF0_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chatd~~]]	+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brady~~, T M~~]]	+	[[Category: Brady TM]]
-	[[Category: Chappie~~, J S~~]]	+	[[Category: Chappie JS]]
-	[[Category: Ford~~, M G.J~~]]	+	[[Category: Ford MGJ]]
-	[[Category: Hosford~~, C J~~]]	+	[[Category: Hosford CJ]]
-	[[Category: Varlakhanova~~, N V]]~~	+	[[Category: Varlakhanova NV]]
-	~~[[Category: Drp]]~~	+
-	~~[[Category: Dynamin-related protein]]~~	+
-	~~[[Category: Endosome]]~~	+
-	~~[[Category: Gmppcp]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Vacuolar protein sorting 1]]~~	+
-	~~[[Category: Vacuole]]~~	+
-	~~[[Category: Vps1~~]]	+

OCA at 11:00, 1 January 2020

2020-01-01T11:00:43Z

←Older revision		Revision as of 11:00, 1 January 2020
Line 1:		Line 1:

	==Vps1 GTPase-BSE fusion complexed with GMPPCP==		==Vps1 GTPase-BSE fusion complexed with GMPPCP==
-	<StructureSection load='6def' size='340' side='right' caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='6def' size='340' side='right'caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6def]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6def]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEF FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Chatd]]		[[Category: Chatd]]
		+	[[Category: Large Structures]]
	[[Category: Brady, T M]]		[[Category: Brady, T M]]
	[[Category: Chappie, J S]]		[[Category: Chappie, J S]]

OCA at 08:35, 17 October 2018

2018-10-17T08:35:44Z

←Older revision		Revision as of 08:35, 17 October 2018
Line 3:		Line 3:
	<StructureSection load='6def' size='340' side='right' caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='6def' size='340' side='right' caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6def]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6def]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0061810 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6def OCA], [http://pdbe.org/6def PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6def RCSB], [http://www.ebi.ac.uk/pdbsum/6def PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6def ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6def OCA], [http://pdbe.org/6def PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6def RCSB], [http://www.ebi.ac.uk/pdbsum/6def PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6def ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Brady, T M]]		[[Category: Brady, T M]]
	[[Category: Chappie, J S]]		[[Category: Chappie, J S]]

OCA at 06:08, 22 August 2018

2018-08-22T06:08:00Z

←Older revision		Revision as of 06:08, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6def is ~~ON HOLD until Paper~~ Publication	+	==Vps1 GTPase-BSE fusion complexed with GMPPCP==
		+	<StructureSection load='6def' size='340' side='right' caption='[[6def]], [[Resolution\|resolution]] 2.26Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6def]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6def OCA], [http://pdbe.org/6def PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6def RCSB], [http://www.ebi.ac.uk/pdbsum/6def PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6def ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dynamin-related proteins (DRPs) are large multidomain GTPases required for diverse membrane-remodeling events. DRPs self-assemble into helical structures, but how these structures are tailored to their cellular targets remains unclear. We demonstrate that the fungal DRP Vps1 primarily localizes to and functions at the endosomal compartment. We present crystal structures of a Vps1 GTPase-bundle signaling element (BSE) fusion in different nucleotide states to capture GTP hydrolysis intermediates and concomitant conformational changes. Using cryoEM, we determined the structure of full-length GMPPCP-bound Vps1. The Vps1 helix is more open and flexible than that of dynamin. This is due to further opening of the BSEs away from the GTPase domains. A novel interface between adjacent GTPase domains forms in Vps1 instead of the contacts between the BSE and adjacent stalks and GTPase domains as seen in dynamin. Disruption of this interface abolishes Vps1 function in vivo. Hence, Vps1 exhibits a unique helical architecture, highlighting structural flexibilities of DRP self-assembly.

-	~~Authors~~:	+	Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture.,Varlakhanova NV, Alvarez FJD, Brady TM, Tornabene BA, Hosford CJ, Chappie JS, Zhang P, Ford MGJ J Cell Biol. 2018 Aug 7. pii: jcb.201712021. doi: 10.1083/jcb.201712021. PMID:30087125<ref>PMID:30087125</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6def" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brady, T M]]
		+	[[Category: Chappie, J S]]
		+	[[Category: Ford, M G.J]]
		+	[[Category: Hosford, C J]]
		+	[[Category: Varlakhanova, N V]]
		+	[[Category: Drp]]
		+	[[Category: Dynamin-related protein]]
		+	[[Category: Endosome]]
		+	[[Category: Gmppcp]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Vacuolar protein sorting 1]]
		+	[[Category: Vacuole]]
		+	[[Category: Vps1]]

OCA at 19:45, 9 August 2018

2018-08-09T19:45:44Z

←Older revision		Revision as of 19:45, 9 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6def is ON HOLD	+	The entry 6def is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6def" [edit=sysop:move=sysop]

2018-05-23T06:00:40Z

Protected "6def" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6def is ON HOLD Authors: Description: Category: Unreleased Structures

2018-05-23T06:00:39Z

New page: '''Unreleased structure''' The entry 6def is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6def is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]