6deh - Revision history

OCA at 06:04, 11 October 2023

2023-10-11T06:04:35Z

←Older revision		Revision as of 06:04, 11 October 2023
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	<StructureSection load='6deh' size='340' side='right'caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6deh' size='340' side='right'caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Legph Legph~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DEH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DEH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6deh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deh OCA], [~~http~~://pdbe.org/6deh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6deh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6deh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6deh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6deh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deh OCA], [https://pdbe.org/6deh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6deh RCSB], [https://www.ebi.ac.uk/pdbsum/6deh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6deh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5ZTE0_LEGPH Q5ZTE0_LEGPH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Legph~~]]	+	[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
-	[[Category: Chung~~, I Y.W~~]]	+	[[Category: Chung IYW]]
-	[[Category: Cygler, M]]	+	[[Category: Cygler M]]
-	~~[[Category: Straaten, K E.van~~]]	+	[[Category: Voth K]]
-	[[Category: Voth, K]]	+	[[Category: Van Straaten KE]]
-	[[Category: ~~Protein binding~~]]	+

OCA at 07:46, 6 November 2019

2019-11-06T07:46:22Z

←Older revision		Revision as of 07:46, 6 November 2019
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	==Structure of LpnE Effector Protein from Legionella pneumophila (sp. Philadelphia)==		==Structure of LpnE Effector Protein from Legionella pneumophila (sp. Philadelphia)==
-	<StructureSection load='6deh' size='340' side='right' caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='6deh' size='340' side='right'caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEH FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Legph]]		[[Category: Legph]]
	[[Category: Chung, I Y.W]]		[[Category: Chung, I Y.W]]

OCA at 15:55, 27 February 2019

2019-02-27T15:55:50Z

←Older revision		Revision as of 15:55, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='6deh' size='340' side='right' caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6deh' size='340' side='right' caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6deh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deh OCA], [http://pdbe.org/6deh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6deh RCSB], [http://www.ebi.ac.uk/pdbsum/6deh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6deh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6deh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deh OCA], [http://pdbe.org/6deh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6deh RCSB], [http://www.ebi.ac.uk/pdbsum/6deh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6deh ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Legph]]
	[[Category: Chung, I Y.W]]		[[Category: Chung, I Y.W]]
	[[Category: Cygler, M]]		[[Category: Cygler, M]]

OCA at 08:19, 19 December 2018

2018-12-19T08:19:02Z

←Older revision		Revision as of 08:19, 19 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6deh is ~~ON HOLD until Paper~~ Publication	+	==Structure of LpnE Effector Protein from Legionella pneumophila (sp. Philadelphia)==
		+	<StructureSection load='6deh' size='340' side='right' caption='[[6deh]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6deh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DEH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6deh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6deh OCA], [http://pdbe.org/6deh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6deh RCSB], [http://www.ebi.ac.uk/pdbsum/6deh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6deh ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Legionella pneumophila is a freshwater bacterium that replicates in predatory amoeba and alveolar macrophage. The ability of L. pneumophila to thrive in eukaryotic host cells is conferred by the Legionella containing vacuole (LCV). Formation and intracellular trafficking of the LCV is governed by an arsenal of effector proteins, many of which are secreted by the Icm/Dot Type 4 Secretion System. One such effector, known as LpnE (L. pneumophila Entry), has been implicated in facilitating bacterial entry into host cells, LCV trafficking and substrate translocation. LpnE belongs to a subfamily of tetratricopeptide repeat proteins known as Sel1-like repeats (SLRs). All eight of the predicted SLRs in LpnE are required to promote host cell invasion. Herein, we report that LpnE(1-375) localizes to cis-Golgi in HEK293 cells via its signal peptide (aa 1-22). We further verify the interaction of LpnE(73-375) and LpnE(22-375) with Oculocerebrorenal syndrome of Lowe protein (OCRL) residues 10-208, restricting the known interacting residues for both proteins. To further characterize the SLR region of LpnE, we solved the crystal structure of LpnE(73-375) to 1.75A resolution. This construct comprises all SLRs, which are arranged in a super-helical fold. The alpha-helices forming the inner concave surface of the LpnE super-helix suggest a potential protein-protein interaction interface. This article is protected by copyright. All rights reserved.

-	~~Authors~~:	+	The structure of Legionella effector protein LpnE provides insights into its interaction with Oculocerebrorenal syndrome of Lowe (OCRL) protein.,Voth K, Chung IYW, van Straaten K, Li L, Boniecki MT, Cygler M FEBS J. 2018 Nov 26. doi: 10.1111/febs.14710. PMID:30479037<ref>PMID:30479037</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6deh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chung, I Y.W]]
		+	[[Category: Cygler, M]]
		+	[[Category: Straaten, K E.van]]
		+	[[Category: Voth, K]]
		+	[[Category: Protein binding]]

OCA: Protected "6deh" [edit=sysop:move=sysop]

2018-05-23T06:00:46Z

Protected "6deh" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6deh is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2018-05-23T06:00:45Z

New page: '''Unreleased structure''' The entry 6deh is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6deh is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]