6dg2 - Revision history

OCA at 06:05, 11 October 2023

2023-10-11T06:05:33Z

←Older revision		Revision as of 06:05, 11 October 2023
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	<StructureSection load='6dg2' size='340' side='right'caption='[[6dg2]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='6dg2' size='340' side='right'caption='[[6dg2]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DG2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DG2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg2 OCA], [~~http~~://pdbe.org/6dg2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dg2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dg2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg2 OCA], [https://pdbe.org/6dg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dg2 RCSB], [https://www.ebi.ac.uk/pdbsum/6dg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6dg2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dg2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Milligan~~, J C~~]]	+	[[Category: Milligan JC]]
-	[[Category: Saphire~~, E O]]~~	+	[[Category: Saphire EO]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Antigen binding fragment]]~~	+
-	~~[[Category: Ebola]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Monoclonal~~]]	+

OCA at 10:07, 18 December 2019

2019-12-18T10:07:31Z

←Older revision		Revision as of 10:07, 18 December 2019
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	==Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6==		==Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6==
-	<StructureSection load='6dg2' size='340' side='right' caption='[[6dg2]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='6dg2' size='340' side='right'caption='[[6dg2]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg2 OCA], [http://pdbe.org/6dg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg2 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg2 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg2 OCA], [http://pdbe.org/6dg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg2 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg2 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Milligan, J C]]		[[Category: Milligan, J C]]
	[[Category: Saphire, E O]]		[[Category: Saphire, E O]]

OCA at 08:03, 26 September 2018

2018-09-26T08:03:51Z

←Older revision		Revision as of 08:03, 26 September 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6dg2 is ~~ON HOLD until Paper~~ Publication	+	==Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6==
		+	<StructureSection load='6dg2' size='340' side='right' caption='[[6dg2]], [[Resolution\|resolution]] 1.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dg2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG2 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg2 OCA], [http://pdbe.org/6dg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg2 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg2 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, though they are ineffective against other members of the Ebolavirus genus which also cause periodic, lethal outbreaks. Here, we present a crystal structure of a pan-ebolavirus antibody, 6D6, as well as single particle electron microscopy reconstructions of 6D6 in complex with Ebola and Bundibugyo virus glycoproteins. 6D6 binds to the conserved glycoprotein fusion peptide, implicating it as a site of immune vulnerability that could be exploited to reliably elicit a pan-ebolavirus neutralizing antibody response.

-	~~Authors~~:	+	Structural Characterization of Pan-ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein.,Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO J Infect Dis. 2018 Sep 10. pii: 5093891. doi: 10.1093/infdis/jiy532. PMID:30203042<ref>PMID:30203042</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6dg2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Milligan, J C]]
		+	[[Category: Saphire, E O]]
		+	[[Category: Antibody]]
		+	[[Category: Antigen binding fragment]]
		+	[[Category: Ebola]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]
		+	[[Category: Monoclonal]]

OCA at 05:19, 18 July 2018

2018-07-18T05:19:38Z

←Older revision		Revision as of 05:19, 18 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dg2 is ON HOLD	+	The entry 6dg2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dg2" [edit=sysop:move=sysop]

2018-05-23T06:04:24Z

Protected "6dg2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:04, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dg2 is ON HOLD Authors: Description: Category: Unreleased Structures

2018-05-23T06:04:23Z

New page: '''Unreleased structure''' The entry 6dg2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dg2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]