6dhr - Revision history

OCA at 10:42, 14 June 2023

2023-06-14T10:42:15Z

←Older revision		Revision as of 10:42, 14 June 2023
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	==NMR Solution structure of Rivi3==		==NMR Solution structure of Rivi3==
-	<StructureSection load='6dhr' size='340' side='right'caption='[[6dhr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6dhr' size='340' side='right'caption='[[6dhr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dhr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DHR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rinorea_virgata Rinorea virgata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DHR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dhr OCA], [~~http~~://pdbe.org/6dhr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dhr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dhr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dhr ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dhr OCA], [https://pdbe.org/6dhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dhr RCSB], [https://www.ebi.ac.uk/pdbsum/6dhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dhr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A4V8GZR4_9ROSI A0A4V8GZR4_9ROSI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Craik, D J~~]]	+	[[Category: Rinorea virgata]]
-	[[Category: ~~Harvey, P J~~]]	+	[[Category: Craik DJ]]
-	[[Category: ~~Cyclotide cyclic peptide]]~~	+	[[Category: Harvey PJ]]
-	~~[[Category: Plant protein~~]]	+

OCA at 05:54, 17 April 2019

2019-04-17T05:54:05Z

←Older revision		Revision as of 05:54, 17 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6dhr is ~~ON HOLD until Paper~~ Publication	+	==NMR Solution structure of Rivi3==
		+	<StructureSection load='6dhr' size='340' side='right'caption='[[6dhr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dhr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DHR FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dhr OCA], [http://pdbe.org/6dhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dhr RCSB], [http://www.ebi.ac.uk/pdbsum/6dhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dhr ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclotides are macrocyclic cystine-knotted peptides most commonly found in the Violaceae plant family. Although Rinorea is the second-largest genera within the Violaceae family, few studies have examined whether or not they contain cyclotides. To further our understanding of cyclotide diversity and evolution, we examined the cyclotide content of two Rinorea species found in Southeast Asia: R. virgata and R. bengalensis. Seven cyclotides were isolated from R. virgata (named Rivi1-7), and a known cyclotide (cT10) was found in R. bengalensis. Loops 2, 5, and 6 of Rivi1-4 contained sequences not previously seen in corresponding loops of known cyclotides, thereby expanding our understanding of the diversity of cyclotides. In addition, the sequence of loop 2 of Rivi3 and Rivi4 were identical to some related noncyclic "acyclotides" from the Poaceae plant family. As only acyclotides, but not cyclotides, have been reported in monocotyledons thus far, our findings support an evolutionary link between monocotyledon-derived ancestral cyclotide precursors and dicotyledon-derived cyclotides. Furthermore, Rivi2 and Rivi3 had comparable cytotoxic activities to the most cytotoxic cyclotide known to date: cycloviolacin O2 from Viola odorata; yet, unlike cycloviolacin O2, they did not show hemolytic activity. Therefore, these cyclotides represent novel scaffolds for use in future anticancer drug design.

-	~~Authors: Harvey~~, P~~.J.~~, ~~Craik~~, D.J.	+	Discovery and Characterization of Cyclotides from Rinorea Species.,Niyomploy P, Chan LY, Harvey PJ, Poth AG, Colgrave ML, Craik DJ J Nat Prod. 2018 Nov 26;81(11):2512-2520. doi: 10.1021/acs.jnatprod.8b00572. Epub, 2018 Nov 2. PMID:30387611<ref>PMID:30387611</ref>

-	~~Description: NMR Solution structure~~ of ~~Rivi3~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Craik, D.J]]	+	<div class="pdbe-citations 6dhr" style="background-color:#fffaf0;"></div>
-	[[Category: Harvey, P.J]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Craik, D J]]
		+	[[Category: Harvey, P J]]
		+	[[Category: Cyclotide cyclic peptide]]
		+	[[Category: Plant protein]]

OCA at 03:59, 20 June 2018

2018-06-20T03:59:07Z

←Older revision		Revision as of 03:59, 20 June 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dhr is ON HOLD	+	The entry 6dhr is ON HOLD until Paper Publication

	Authors: Harvey, P.J., Craik, D.J.		Authors: Harvey, P.J., Craik, D.J.

OCA: Protected "6dhr" [edit=sysop:move=sysop]

2018-05-30T04:08:22Z

Protected "6dhr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dhr is ON HOLD Authors: Harvey, P.J., Craik, D.J. Description: NMR Solution structure of Rivi3 Category: Unreleased Structures [[Category: Cra...

2018-05-30T04:08:21Z

New page: '''Unreleased structure''' The entry 6dhr is ON HOLD Authors: Harvey, P.J., Craik, D.J. Description: NMR Solution structure of Rivi3 Category: Unreleased Structures [[Category: Cra...

New page

'''Unreleased structure'''

The entry 6dhr is ON HOLD

Authors: Harvey, P.J., Craik, D.J.

Description: NMR Solution structure of Rivi3
[[Category: Unreleased Structures]]
[[Category: Craik, D.J]]
[[Category: Harvey, P.J]]