6dlw - Revision history

OCA at 00:06, 11 April 2020

2020-04-11T00:06:26Z

←Older revision		Revision as of 00:06, 11 April 2020
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	<SX load='6dlw' size='340' side='right' viewer='molstar' caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>		<SX load='6dlw' size='340' side='right' viewer='molstar' caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DLW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlw OCA], [http://pdbe.org/6dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlw RCSB], [http://www.ebi.ac.uk/pdbsum/6dlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlw OCA], [http://pdbe.org/6dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlw RCSB], [http://www.ebi.ac.uk/pdbsum/6dlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlw ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:55, 6 March 2020

2020-03-06T20:55:15Z

←Older revision		Revision as of 20:55, 6 March 2020
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	==Complement component polyC9==		==Complement component polyC9==
-	<~~StructureSection~~ load='6dlw' size='340' side='right'caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<SX load='6dlw' size='340' side='right' viewer='molstar' caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLW FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:05, 1 January 2020

2020-01-01T11:05:30Z

←Older revision		Revision as of 11:05, 1 January 2020
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	==Complement component polyC9==		==Complement component polyC9==
-	<StructureSection load='6dlw' size='340' side='right' caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<StructureSection load='6dlw' size='340' side='right'caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlw OCA], [http://pdbe.org/6dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlw RCSB], [http://www.ebi.ac.uk/pdbsum/6dlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlw OCA], [http://pdbe.org/6dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlw RCSB], [http://www.ebi.ac.uk/pdbsum/6dlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlw ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dunstone, M A]]		[[Category: Dunstone, M A]]
	[[Category: Law, R H.P]]		[[Category: Law, R H.P]]

OCA at 07:36, 12 September 2018

2018-09-12T07:36:16Z

←Older revision		Revision as of 07:36, 12 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dlw is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Complement component polyC9==
		+	<StructureSection load='6dlw' size='340' side='right' caption='[[6dlw]], [[Resolution\|resolution]] 3.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dlw]] is a 22 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlw OCA], [http://pdbe.org/6dlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlw RCSB], [http://www.ebi.ac.uk/pdbsum/6dlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlw ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN]] Age-related macular degeneration;Immunodeficiency due to a late component of complements deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complement component 9 (C9) functions as the pore-forming component of the Membrane Attack Complex (MAC). During MAC assembly, multiple copies of C9 are sequentially recruited to membrane associated C5b8 to form a pore. Here we determined the 2.2 A crystal structure of monomeric murine C9 and the 3.9 A resolution cryo EM structure of C9 in a polymeric assembly. Comparison with other MAC proteins reveals that the first transmembrane region (TMH1) in monomeric C9 is uniquely positioned and functions to inhibit its self-assembly in the absence of C5b8. We further show that following C9 recruitment to C5b8, a conformational change in TMH1 permits unidirectional and sequential binding of additional C9 monomers to the growing MAC. This mechanism of pore formation contrasts with related proteins, such as perforin and the cholesterol dependent cytolysins, where it is believed that pre-pore assembly occurs prior to the simultaneous release of the transmembrane regions.

-	~~Authors~~:	+	The first transmembrane region of complement component-9 acts as a brake on its self-assembly.,Spicer BA, Law RHP, Caradoc-Davies TT, Ekkel SM, Bayly-Jones C, Pang SS, Conroy PJ, Ramm G, Radjainia M, Venugopal H, Whisstock JC, Dunstone MA Nat Commun. 2018 Aug 15;9(1):3266. doi: 10.1038/s41467-018-05717-0. PMID:30111885<ref>PMID:30111885</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6dlw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dunstone, M A]]
		+	[[Category: Law, R H.P]]
		+	[[Category: Spicer, B A]]
		+	[[Category: Complement]]
		+	[[Category: Em]]
		+	[[Category: Immune system]]
		+	[[Category: Membrane]]
		+	[[Category: Pore]]
		+	[[Category: Transmembrane]]

OCA at 03:58, 27 June 2018

2018-06-27T03:58:05Z

←Older revision		Revision as of 03:58, 27 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dlw is ON HOLD	+	The entry 6dlw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dlw" [edit=sysop:move=sysop]

2018-06-14T05:41:21Z

Protected "6dlw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 14 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dlw is ON HOLD Authors: Description: Category: Unreleased Structures

2018-06-14T05:41:20Z

New page: '''Unreleased structure''' The entry 6dlw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dlw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]