6duw - Revision history

OCA at 06:14, 11 October 2023

2023-10-11T06:14:27Z

←Older revision		Revision as of 06:14, 11 October 2023
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	<StructureSection load='6duw' size='340' side='right'caption='[[6duw]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6duw' size='340' side='right'caption='[[6duw]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6duw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6duw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DUW FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CTNNA2~~, ~~CAPR (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6duw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duw OCA], [~~http~~://pdbe.org/6duw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6duw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6duw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6duw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6duw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duw OCA], [https://pdbe.org/6duw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6duw RCSB], [https://www.ebi.ac.uk/pdbsum/6duw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6duw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CTNA2_HUMAN CTNA2_HUMAN]] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.[UniProtKB:Q61301]	+	[https://www.uniprot.org/uniprot/CTNA2_HUMAN CTNA2_HUMAN] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.[UniProtKB:Q61301]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ikura, M]]	+	[[Category: Ikura M]]
-	[[Category: Ishiyama, N]]	+	[[Category: Ishiyama N]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: F-actin-binding]]~~	+
-	~~[[Category: Five-helix bundle]]~~	+
-	~~[[Category: Mechanosensor~~]]	+

OCA at 08:54, 8 January 2020

2020-01-08T08:54:54Z

←Older revision		Revision as of 08:54, 8 January 2020
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	==Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant==		==Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant==
-	<StructureSection load='6duw' size='340' side='right' caption='[[6duw]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='6duw' size='340' side='right'caption='[[6duw]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6duw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6duw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6duw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duw OCA], [http://pdbe.org/6duw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6duw RCSB], [http://www.ebi.ac.uk/pdbsum/6duw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6duw ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTNNA2, CAPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6duw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duw OCA], [http://pdbe.org/6duw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6duw RCSB], [http://www.ebi.ac.uk/pdbsum/6duw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6duw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 6duw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6duw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Catenin 3D structures\|Catenin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ikura, M]]		[[Category: Ikura, M]]
	[[Category: Ishiyama, N]]		[[Category: Ishiyama, N]]

OCA at 08:24, 19 December 2018

2018-12-19T08:24:32Z

←Older revision		Revision as of 08:24, 19 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6duw is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant==
		+	<StructureSection load='6duw' size='340' side='right' caption='[[6duw]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6duw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUW FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6duw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duw OCA], [http://pdbe.org/6duw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6duw RCSB], [http://www.ebi.ac.uk/pdbsum/6duw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6duw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CTNA2_HUMAN CTNA2_HUMAN]] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.[UniProtKB:Q61301]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	alpha-catenin is a key mechanosensor that forms force-dependent interactions with F-actin, thereby coupling the cadherin-catenin complex to the actin cytoskeleton at adherens junctions (AJs). However, the molecular mechanisms by which alpha-catenin engages F-actin under tension remained elusive. Here we show that the alpha1-helix of the alpha-catenin actin-binding domain (alphacat-ABD) is a mechanosensing motif that regulates tension-dependent F-actin binding and bundling. alphacat-ABD containing an alpha1-helix-unfolding mutation (H1) shows enhanced binding to F-actin in vitro. Although full-length alpha-catenin-H1 can generate epithelial monolayers that resist mechanical disruption, it fails to support normal AJ regulation in vivo. Structural and simulation analyses suggest that alpha1-helix allosterically controls the actin-binding residue V796 dynamics. Crystal structures of alphacat-ABD-H1 homodimer suggest that alpha-catenin can facilitate actin bundling while it remains bound to E-cadherin. We propose that force-dependent allosteric regulation of alphacat-ABD promotes dynamic interactions with F-actin involved in actin bundling, cadherin clustering, and AJ remodeling during tissue morphogenesis.

-	~~Authors: Ishiyama~~, N., ~~Ikura~~, M.	+	Force-dependent allostery of the alpha-catenin actin-binding domain controls adherens junction dynamics and functions.,Ishiyama N, Sarpal R, Wood MN, Barrick SK, Nishikawa T, Hayashi H, Kobb AB, Flozak AS, Yemelyanov A, Fernandez-Gonzalez R, Yonemura S, Leckband DE, Gottardi CJ, Tepass U, Ikura M Nat Commun. 2018 Nov 30;9(1):5121. doi: 10.1038/s41467-018-07481-7. PMID:30504777<ref>PMID:30504777</ref>

-	~~Description: Crystal structure~~ of the ~~alpha~~-N-~~catenin actin-binding domain H1 mutant~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6duw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ikura, M]]		[[Category: Ikura, M]]
	[[Category: Ishiyama, N]]		[[Category: Ishiyama, N]]
		+	[[Category: Cell adhesion]]
		+	[[Category: F-actin-binding]]
		+	[[Category: Five-helix bundle]]
		+	[[Category: Mechanosensor]]

OCA at 05:49, 25 July 2018

2018-07-25T05:49:37Z

←Older revision		Revision as of 05:49, 25 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6duw is ON HOLD	+	The entry 6duw is ON HOLD until Paper Publication

	Authors: Ishiyama, N., Ikura, M.		Authors: Ishiyama, N., Ikura, M.

OCA: Protected "6duw" [edit=sysop:move=sysop]

2018-07-04T05:43:14Z

Protected "6duw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:43, 4 July 2018

OCA: New page: '''Unreleased structure''' The entry 6duw is ON HOLD Authors: Ishiyama, N., Ikura, M. Description: Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant [[Category: U...

2018-07-04T05:43:13Z

New page: '''Unreleased structure''' The entry 6duw is ON HOLD Authors: Ishiyama, N., Ikura, M. Description: Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant [[Category: U...

New page

'''Unreleased structure'''

The entry 6duw is ON HOLD

Authors: Ishiyama, N., Ikura, M.

Description: Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant
[[Category: Unreleased Structures]]
[[Category: Ikura, M]]
[[Category: Ishiyama, N]]