6eel - Revision history

OCA at 06:24, 11 October 2023

2023-10-11T06:24:54Z

←Older revision		Revision as of 06:24, 11 October 2023
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	<StructureSection load='6eel' size='340' side='right'caption='[[6eel]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='6eel' size='340' side='right'caption='[[6eel]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eel]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eel]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EEL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SR:STRONTIUM+ION'>SR</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2dmh\|2dmh]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MYOF, FER1L3, KIAA1207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eel OCA], [https://pdbe.org/6eel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eel RCSB], [https://www.ebi.ac.uk/pdbsum/6eel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eel ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6eel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eel OCA], [~~http~~://pdbe.org/6eel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6eel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6eel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6eel ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYOF_HUMAN MYOF_HUMAN]] Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).	+	[https://www.uniprot.org/uniprot/MYOF_HUMAN MYOF_HUMAN] Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harsini~~, F M~~]]	+	[[Category: Harsini FM]]
-	[[Category: Rice~~, A M~~]]	+	[[Category: Rice AM]]
-	[[Category: Sutton~~, R B]]~~	+	[[Category: Sutton RB]]
-	~~[[Category: C2 domain]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Ferlin]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 23:02, 5 June 2019

2019-06-05T23:02:01Z

←Older revision		Revision as of 23:02, 5 June 2019
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	<StructureSection load='6eel' size='340' side='right'caption='[[6eel]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='6eel' size='340' side='right'caption='[[6eel]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eel]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eel]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYOF, FER1L3, KIAA1207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eel OCA], [http://pdbe.org/6eel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eel RCSB], [http://www.ebi.ac.uk/pdbsum/6eel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eel OCA], [http://pdbe.org/6eel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eel RCSB], [http://www.ebi.ac.uk/pdbsum/6eel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eel ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Harsini, F M]]		[[Category: Harsini, F M]]

OCA at 06:45, 23 May 2019

2019-05-23T06:45:08Z

←Older revision		Revision as of 06:45, 23 May 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6eel is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of Myoferlin C2A with divalent cation==
		+	<StructureSection load='6eel' size='340' side='right'caption='[[6eel]], [[Resolution\|resolution]] 1.93Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6eel]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EEL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eel OCA], [http://pdbe.org/6eel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eel RCSB], [http://www.ebi.ac.uk/pdbsum/6eel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eel ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYOF_HUMAN MYOF_HUMAN]] Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dysferlin has been implicated in acute membrane repair processes, whereas myoferlin's activity is maximal during the myoblast fusion stage of early skeletal muscle cell development. Both proteins are similar in size and domain structure; however, despite the overall similarity, myoferlin's known physiological functions do not overlap with those of dysferlin. Here we present for the first time the X-ray crystal structure of human myoferlin C2A to 1.9 A resolution bound to two divalent cations, and compare its three-dimensional structure and membrane binding activities to that of dysferlin C2A. We find that while dysferlin C2A binds membranes in a Ca(2+)-dependent manner, Ca(2+) binding was the rate-limiting kinetic step for this interaction. Myoferlin C2A, on the other hand, binds two calcium ions with an affinity 3-fold lower than that of dysferlin C2A; and, surprisingly, myoferlin C2A binds only marginally to phospholipid mixtures with a high fraction of phosphatidylserine.

-	~~Authors: Sutton, R.B~~., Harsini, ~~F.M.~~, Rice, A.M.	+	Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin.,Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB J Mol Biol. 2019 Apr 18. pii: S0022-2836(19)30188-3. doi:, 10.1016/j.jmb.2019.04.006. PMID:31004665<ref>PMID:31004665</ref>

-	~~Description: Crystal Structure~~ of ~~Myoferlin C2A with divalent cation~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Harsini, F.M]]	+	<div class="pdbe-citations 6eel" style="background-color:#fffaf0;"></div>
-	[[Category: Sutton, R.B]]	+	== References ==
-	[[Category: ~~Rice, A.M~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Harsini, F M]]
		+	[[Category: Rice, A M]]
		+	[[Category: Sutton, R B]]
		+	[[Category: C2 domain]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Ferlin]]
		+	[[Category: Metal binding protein]]

OCA at 05:58, 12 September 2018

2018-09-12T05:58:42Z

←Older revision		Revision as of 05:58, 12 September 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6eel is ON HOLD	+	The entry 6eel is ON HOLD until Paper Publication

	Authors: Sutton, R.B., Harsini, F.M., Rice, A.M.		Authors: Sutton, R.B., Harsini, F.M., Rice, A.M.

OCA: Protected "6eel" [edit=sysop:move=sysop]

2018-08-22T04:45:56Z

Protected "6eel" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:45, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6eel is ON HOLD Authors: Sutton, R.B., Harsini, F.M., Rice, A.M. Description: Crystal Structure of Myoferlin C2A with divalent cation [[Category: U...

2018-08-22T04:45:55Z

New page: '''Unreleased structure''' The entry 6eel is ON HOLD Authors: Sutton, R.B., Harsini, F.M., Rice, A.M. Description: Crystal Structure of Myoferlin C2A with divalent cation [[Category: U...

New page

'''Unreleased structure'''

The entry 6eel is ON HOLD

Authors: Sutton, R.B., Harsini, F.M., Rice, A.M.

Description: Crystal Structure of Myoferlin C2A with divalent cation
[[Category: Unreleased Structures]]
[[Category: Harsini, F.M]]
[[Category: Sutton, R.B]]
[[Category: Rice, A.M]]