6eff - Revision history

OCA at 10:08, 22 May 2024

2024-05-22T10:08:15Z

←Older revision		Revision as of 10:08, 22 May 2024
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	<StructureSection load='6eff' size='340' side='right'caption='[[6eff]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6eff' size='340' side='right'caption='[[6eff]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eff]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EFF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eff]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EFF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6efc\|6efc]], [[6efd\|6efd]], [[6efi\|6efi]], [[6ef7\|6ef7]], [[5iud\|5iud]], [[6ef9\|6ef9]], [[6efa\|6efa]], [[6efb\|6efb]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eff OCA], [~~http~~://pdbe.org/6eff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6eff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6eff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6eff ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eff OCA], [https://pdbe.org/6eff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eff RCSB], [https://www.ebi.ac.uk/pdbsum/6eff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eff ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial binding to host receptors underlies both commensalism and pathogenesis. Many streptococci adhere to protein-attached carbohydrates expressed on cell surfaces using Siglec-like binding regions (SLBRs). The precise glycan repertoire recognized may dictate whether the organism is a strict commensal versus a pathogen. However, it is currently not clear what drives receptor selectivity. Here, we use five representative SLBRs and identify regions of the receptor binding site that are hypervariable in sequence and structure. We show that these regions control the identity of the preferred carbohydrate ligand using chimeragenesis and single amino acid substitutions. We further evaluate how the identity of the preferred ligand affects the interaction with glycoprotein receptors in human saliva and plasma samples. As point mutations can change the preferred human receptor, these studies suggest how streptococci may adapt to changes in the environmental glycan repertoire.
		+
		+	Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.,Bensing BA, Stubbs HE, Agarwal R, Yamakawa I, Luong K, Solakyildirim K, Yu H, Hadadianpour A, Castro MA, Fialkowski KP, Morrison KM, Wawrzak Z, Chen X, Lebrilla CB, Baudry J, Smith JC, Sullam PM, Iverson TM Nat Commun. 2022 May 18;13(1):2753. doi: 10.1038/s41467-022-30509-y. PMID:35585145<ref>PMID:35585145</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6eff" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Iverson, T M~~]]	+	[[Category: Streptococcus mitis]]
-	[[Category: ~~Lectin]]~~	+	[[Category: Iverson TM]]
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 06:16, 19 February 2020

2020-02-19T06:16:59Z

←Older revision		Revision as of 06:16, 19 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6eff is ~~ON HOLD until Paper Publication~~	+	==NCTC10712==
-		+	<StructureSection load='6eff' size='340' side='right'caption='[[6eff]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Iverson~~, T.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6eff]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EFF FirstGlance]. <br>
-	~~Description: NCTC10712~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6efc\|6efc]], [[6efd\|6efd]], [[6efi\|6efi]], [[6ef7\|6ef7]], [[5iud\|5iud]], [[6ef9\|6ef9]], [[6efa\|6efa]], [[6efb\|6efb]]</td></tr>
-	[[Category: Iverson, T.M]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eff OCA], [http://pdbe.org/6eff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eff RCSB], [http://www.ebi.ac.uk/pdbsum/6eff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eff ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Iverson, T M]]
		+	[[Category: Lectin]]
		+	[[Category: Sugar binding protein]]

OCA at 06:09, 10 October 2018

2018-10-10T06:09:43Z

←Older revision		Revision as of 06:09, 10 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6eff is ON HOLD	+	The entry 6eff is ON HOLD until Paper Publication

	Authors: Iverson, T.M.		Authors: Iverson, T.M.

OCA: Protected "6eff" [edit=sysop:move=sysop]

2018-08-22T04:48:33Z

Protected "6eff" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:48, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6eff is ON HOLD Authors: Iverson, T.M. Description: NCTC10712 Category: Unreleased Structures Category: Iverson, T.M

2018-08-22T04:48:31Z

New page: '''Unreleased structure''' The entry 6eff is ON HOLD Authors: Iverson, T.M. Description: NCTC10712 Category: Unreleased Structures Category: Iverson, T.M

New page

'''Unreleased structure'''

The entry 6eff is ON HOLD

Authors: Iverson, T.M.

Description: NCTC10712
[[Category: Unreleased Structures]]
[[Category: Iverson, T.M]]