6ejb - Revision history

OCA at 08:12, 14 June 2018

2018-06-14T08:12:29Z

←Older revision		Revision as of 08:12, 14 June 2018
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	<StructureSection load='6ejb' size='340' side='right' caption='[[6ejb]], [[Resolution\|resolution]] 2.56Å' scene=''>		<StructureSection load='6ejb' size='340' side='right' caption='[[6ejb]], [[Resolution\|resolution]] 2.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ejb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ejb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">XYLT1, XT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_xylosyltransferase Protein xylosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.26 2.4.2.26] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_xylosyltransferase Protein xylosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.26 2.4.2.26] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejb OCA], [http://pdbe.org/6ejb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejb RCSB], [http://www.ebi.ac.uk/pdbsum/6ejb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejb OCA], [http://pdbe.org/6ejb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejb RCSB], [http://www.ebi.ac.uk/pdbsum/6ejb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejb ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Protein xylosyltransferase]]		[[Category: Protein xylosyltransferase]]
	[[Category: Briggs, D C]]		[[Category: Briggs, D C]]

OCA at 08:13, 2 May 2018

2018-05-02T08:13:38Z

←Older revision		Revision as of 08:13, 2 May 2018
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-	'''Unreleased structure'''

-	The entry ~~6ejb~~ is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human Xylosyltransferase 1 in complex with peptide QEEEGSAGGQGG==
		+	<StructureSection load='6ejb' size='340' side='right' caption='[[6ejb]], [[Resolution\|resolution]] 2.56Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ejb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_xylosyltransferase Protein xylosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.26 2.4.2.26] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejb OCA], [http://pdbe.org/6ejb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejb RCSB], [http://www.ebi.ac.uk/pdbsum/6ejb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejb ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/XYLT1_HUMAN XYLT1_HUMAN]] XYLT1-CDG;Desbuquois syndrome. The disease is caused by mutations affecting the gene represented in this entry. The gene represented in this entry acts as a disease modifier.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/XYLT1_HUMAN XYLT1_HUMAN]] Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.<ref>PMID:15461586</ref> [[http://www.uniprot.org/uniprot/AMBP_HUMAN AMBP_HUMAN]] Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.<ref>PMID:7676539</ref> Trypstatin is a trypsin inhibitor (By similarity).<ref>PMID:7676539</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteoglycans (PGs) are essential components of the animal extracellular matrix and are required for cell adhesion, migration, signaling, and immune function. PGs are composed of a core protein and long glycosaminoglycan (GAG) chains, which often specify PG function. GAG biosynthesis is initiated by peptide O-xylosyltransferases, which transfer xylose onto selected serine residues in the core proteins. We have determined crystal structures of human xylosyltransferase 1 (XT1) in complex with the sugar donor, UDP-xylose, and various acceptor peptides. The structures reveal unique active-site features that, in conjunction with functional experiments, explain the substrate specificity of XT1. A constriction within the peptide binding cleft requires the acceptor serine to be followed by glycine or alanine. The remainder of the cleft can accommodate a wide variety of sequences, but with a general preference for acidic residues. These findings provide a framework for understanding the selectivity of GAG attachment.

-	~~Authors~~:	+	Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.,Briggs DC, Hohenester E Structure. 2018 Apr 10. pii: S0969-2126(18)30095-9. doi:, 10.1016/j.str.2018.03.014. PMID:29681470<ref>PMID:29681470</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6ejb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein xylosyltransferase]]
		+	[[Category: Briggs, D C]]
		+	[[Category: Hohenester, E]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Golgi]]
		+	[[Category: Proteoglycan]]
		+	[[Category: Transferase]]
		+	[[Category: Xylosyltransferase]]

OCA: Protected "6ejb" [edit=sysop:move=sysop]

2017-09-27T17:14:37Z

Protected "6ejb" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:14, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6ejb is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T17:14:36Z

New page: '''Unreleased structure''' The entry 6ejb is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ejb is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]