6exe - Revision history

OCA at 06:23, 8 March 2018

2018-03-08T06:23:15Z

←Older revision		Revision as of 06:23, 8 March 2018
Line 3:		Line 3:
	<StructureSection load='6exe' size='340' side='right' caption='[[6exe]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6exe' size='340' side='right' caption='[[6exe]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6exe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EXE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6exe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EXE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icmP, lpg0445 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6exe OCA], [http://pdbe.org/6exe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6exe RCSB], [http://www.ebi.ac.uk/pdbsum/6exe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6exe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6exe OCA], [http://pdbe.org/6exe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6exe RCSB], [http://www.ebi.ac.uk/pdbsum/6exe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6exe ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Legionella pneumophila, a causative agent of pneumonia, utilizes the Type 4B secretion (T4BS) system to translocate over 300 effectors into the host cell during infection. T4BS systems are encoded by a large gene cluster termed dot/icm, three components of which, DotL, DotM, and DotN, form the "coupling complex", which serves as a platform for recruitment of effector proteins. One class of effectors includes proteins containing Glu-rich/E-block sequences at their C terminus. However, the protein or region of the coupling complex mediating recruitment of such effectors is unknown. Here we present the crystal structure of DotM. This all alpha-helical structure exhibits patches of positively charged residues. We show that these regions form binding sites for acidic Glu-rich peptides and that mutants targeting these patches are defective in vivo in the translocation of acidic Glu-rich motif-containing effectors. We conclude that DotM forms the interacting surface for recruitment of acidic Glu-rich motif-containing Legionella effectors.
		+
		+	Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system.,Meir A, Chetrit D, Liu L, Roy CR, Waksman G Nat Commun. 2018 Feb 6;9(1):507. doi: 10.1038/s41467-017-02578-x. PMID:29410427<ref>PMID:29410427</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6exe" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Legph]]
	[[Category: Meir, A]]		[[Category: Meir, A]]
	[[Category: Waksman, G]]		[[Category: Waksman, G]]

OCA at 06:36, 15 February 2018

2018-02-15T06:36:34Z

←Older revision		Revision as of 06:36, 15 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6exe is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of DotM cytoplasmic domain (residues 153-380),R217E==
-		+	<StructureSection load='6exe' size='340' side='right' caption='[[6exe]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6exe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EXE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6exe OCA], [http://pdbe.org/6exe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6exe RCSB], [http://www.ebi.ac.uk/pdbsum/6exe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6exe ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Meir, A]]
		+	[[Category: Waksman, G]]
		+	[[Category: Coupling complex]]
		+	[[Category: Legionella pneumophila]]
		+	[[Category: Membrane protein]]
		+	[[Category: Protein binding]]
		+	[[Category: Secretion system]]
		+	[[Category: Type 4 secretion system]]

OCA at 06:10, 6 December 2017

2017-12-06T06:10:02Z

←Older revision		Revision as of 06:10, 6 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6exe is ON HOLD	+	The entry 6exe is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6exe" [edit=sysop:move=sysop]

2017-11-15T06:31:35Z

Protected "6exe" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:31, 15 November 2017

OCA: New page: '''Unreleased structure''' The entry 6exe is ON HOLD Authors: Description: Category: Unreleased Structures

2017-11-15T06:31:33Z

New page: '''Unreleased structure''' The entry 6exe is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6exe is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]