6ez2 - Revision history

OCA at 07:48, 7 February 2024

2024-02-07T07:48:42Z

←Older revision		Revision as of 07:48, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXT:(2~{S})-2-azanyl-3-[ethyl(methyl)carbamoyl]oxy-propanoic+acid'>BXT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXT:(2~{S})-2-azanyl-3-[ethyl(methyl)carbamoyl]oxy-propanoic+acid'>BXT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [https://pdbe.org/6ez2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [https://pdbe.org/6ez2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:40, 8 March 2023

2023-03-08T07:40:23Z

←Older revision		Revision as of 07:40, 8 March 2023
Line 3:		Line 3:
	<StructureSection load='6ez2' size='340' side='right'caption='[[6ez2]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6ez2' size='340' side='right'caption='[[6ez2]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXT:(2~{S})-2-azanyl-3-[ethyl(methyl)carbamoyl]oxy-propanoic+acid'>BXT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXT:'>BXT</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [https://pdbe.org/6ez2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [~~http~~://pdbe.org/6ez2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[~~http~~://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.	+	[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>	+	[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
		+
		+	==See Also==
		+	*[[Butyrylcholinesterase 3D structures\|Butyrylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cholinesterase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brazzolotto, X]]	+	[[Category: Brazzolotto X]]
-	[[Category: Dighe~~, S N]]~~	+	[[Category: Dighe SN]]
-	~~[[Category: Mora, E de la~~]]	+	[[Category: Ross BP]]
-	[[Category: Ross~~, B P~~]]	+	[[Category: De la Mora E]]
-	[[Category: ~~Alzheimer disease]]~~	+
-	~~[[Category: Butyrylcholinesterase]]~~	+
-	~~[[Category: Central nervous system]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Rivastigmine analogue~~]]	+

OCA at 06:33, 29 May 2019

2019-05-29T06:33:33Z

←Older revision		Revision as of 06:33, 29 May 2019
Line 1:		Line 1:

	==Human butyrylcholinesterase carbamylated.==		==Human butyrylcholinesterase carbamylated.==
-	<StructureSection load='6ez2' size='340' side='right' caption='[[6ez2]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='6ez2' size='340' side='right'caption='[[6ez2]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXT:'>BXT</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXT:'>BXT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [http://pdbe.org/6ez2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [http://pdbe.org/6ez2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>
Line 18:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brazzolotto, X]]		[[Category: Brazzolotto, X]]
	[[Category: Dighe, S N]]		[[Category: Dighe, S N]]

OCA at 06:46, 12 December 2018

2018-12-12T06:46:53Z

←Older revision		Revision as of 06:46, 12 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ez2 is ~~ON HOLD until Paper Publication~~	+	==Human butyrylcholinesterase carbamylated.==
-		+	<StructureSection load='6ez2' size='340' side='right' caption='[[6ez2]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~Authors~~: ~~Brazzolotto~~, X., ~~de la Mora~~, E., ~~Dighe~~, S.N., ~~Ross, B~~.P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ez2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EZ2 FirstGlance]. <br>
-	~~Description~~: ~~Human~~ butyrylcholinesterase ~~carbamylated~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXT:'>BXT</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ez2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ez2 OCA], [http://pdbe.org/6ez2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ez2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ez2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ez2 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cholinesterase]]
	[[Category: Brazzolotto, X]]		[[Category: Brazzolotto, X]]
-	[[Category: Dighe, S.N]]	+	[[Category: Dighe, S N]]
-	[[Category: Ross, B.P]]	+	[[Category: Mora, E de la]]
-	[[Category: ~~De La Mora, E~~]]	+	[[Category: Ross, B P]]
		+	[[Category: Alzheimer disease]]
		+	[[Category: Butyrylcholinesterase]]
		+	[[Category: Central nervous system]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Rivastigmine analogue]]

OCA: Protected "6ez2" [edit=sysop:move=sysop]

2017-11-22T06:43:41Z

Protected "6ez2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 6ez2 is ON HOLD until Paper Publication Authors: Brazzolotto, X., de la Mora, E., Dighe, S.N., Ross, B.P. Description: Human butyrylcholinesterase ...

2017-11-22T06:43:40Z

New page: '''Unreleased structure''' The entry 6ez2 is ON HOLD until Paper Publication Authors: Brazzolotto, X., de la Mora, E., Dighe, S.N., Ross, B.P. Description: Human butyrylcholinesterase ...

New page

'''Unreleased structure'''

The entry 6ez2 is ON HOLD until Paper Publication

Authors: Brazzolotto, X., de la Mora, E., Dighe, S.N., Ross, B.P.

Description: Human butyrylcholinesterase carbamylated.
[[Category: Unreleased Structures]]
[[Category: Brazzolotto, X]]
[[Category: Dighe, S.N]]
[[Category: Ross, B.P]]
[[Category: De La Mora, E]]