6fc5 - Revision history

OCA at 12:26, 9 May 2024

2024-05-09T12:26:53Z

←Older revision		Revision as of 12:26, 9 May 2024
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	==Bik1 CAP-Gly domain==		==Bik1 CAP-Gly domain==
-	<StructureSection load='6fc5' size='340' side='right' caption='[[6fc5]], [[Resolution\|resolution]] 1.88Å' scene=''>	+	<StructureSection load='6fc5' size='340' side='right'caption='[[6fc5]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FC5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc5 OCA], [~~http~~://pdbe.org/6fc5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fc5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fc5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc5 OCA], [https://pdbe.org/6fc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fc5 RCSB], [https://www.ebi.ac.uk/pdbsum/6fc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BIK1_YEAST BIK1_YEAST] Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6fc5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fc5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Microtubule-associated protein 3D structures\|Microtubule-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Kumar, A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Stangier, M M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Steinmetz, M O~~]]	+	[[Category: Kumar A]]
-	[[Category: ~~Tip~~]]	+	[[Category: Stangier MM]]
-	[[Category: ~~Cap-gly]]~~	+	[[Category: Steinmetz MO]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Yeast~~]]	+

OCA at 13:57, 11 April 2018

2018-04-11T13:57:17Z

←Older revision		Revision as of 13:57, 11 April 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6fc5 is ~~ON HOLD~~	+	==Bik1 CAP-Gly domain==
		+	<StructureSection load='6fc5' size='340' side='right' caption='[[6fc5]], [[Resolution\|resolution]] 1.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc5 OCA], [http://pdbe.org/6fc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc5 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc5 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In budding yeast, the microtubule plus-end tracking proteins Bik1 (CLIP-170) and Bim1 (EB1) form a complex that interacts with partners involved in spindle positioning, including Stu2 and Kar9. Here, we show that the CAP-Gly and coiled-coil domains of Bik1 interact with the C-terminal ETF peptide of Bim1 and the C-terminal tail region of Stu2, respectively. The crystal structures of the CAP-Gly domain of Bik1 (Bik1CG) alone and in complex with an ETF peptide revealed unique, functionally relevant CAP-Gly elements, establishing Bik1CG as a specific C-terminal phenylalanine recognition domain. Unlike the mammalian CLIP-170-EB1 complex, Bik1-Bim1 forms ternary complexes with the EB1-binding motifs SxIP and LxxPTPh, which are present in diverse proteins, including Kar9. Perturbation of the Bik1-Bim1 interaction in vivo affected Bik1 localization and astral microtubule length. Our results provide insight into the role of the Bik1-Bim1 interaction for cell division, and demonstrate that the CLIP-170-EB1 module is evolutionarily flexible.

-	~~Authors: Kumar, A~~., Stangier, ~~M.M.~~, ~~Steinmetz~~, M.O.	+	Structure-Function Relationship of the Bik1-Bim1 Complex.,Stangier MM, Kumar A, Chen X, Farcas AM, Barral Y, Steinmetz MO Structure. 2018 Apr 3;26(4):607-618.e4. doi: 10.1016/j.str.2018.03.003. Epub 2018, Mar 22. PMID:29576319<ref>PMID:29576319</ref>

-	~~Description: Bik1 CAP-Gly domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6fc5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kumar, A]]		[[Category: Kumar, A]]
-	[[Category: ~~Steinmetz~~, M.O]]	+	[[Category: Stangier, M M]]
-	[[Category: ~~Stangier~~, M.M]]	+	[[Category: Steinmetz, M O]]
		+	[[Category: Tip]]
		+	[[Category: Cap-gly]]
		+	[[Category: Cell cycle]]
		+	[[Category: Microtubule]]
		+	[[Category: Yeast]]

OCA: Protected "6fc5" [edit=sysop:move=sysop]

2017-12-27T07:33:16Z

Protected "6fc5" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:33, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6fc5 is ON HOLD Authors: Kumar, A., Stangier, M.M., Steinmetz, M.O. Description: Bik1 CAP-Gly domain Category: Unreleased Structures [[Category...

2017-12-27T07:33:14Z

New page: '''Unreleased structure''' The entry 6fc5 is ON HOLD Authors: Kumar, A., Stangier, M.M., Steinmetz, M.O. Description: Bik1 CAP-Gly domain Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 6fc5 is ON HOLD

Authors: Kumar, A., Stangier, M.M., Steinmetz, M.O.

Description: Bik1 CAP-Gly domain
[[Category: Unreleased Structures]]
[[Category: Kumar, A]]
[[Category: Steinmetz, M.O]]
[[Category: Stangier, M.M]]