6fcj - Revision history

OCA at 12:26, 9 May 2024

2024-05-09T12:26:58Z

←Older revision		Revision as of 12:26, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='6fcj' size='340' side='right'caption='[[6fcj]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='6fcj' size='340' side='right'caption='[[6fcj]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FCJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=D4W:4~~-[2~~-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D4W:4-[2-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [~~http~~://pdbe.org/6fcj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [https://pdbe.org/6fcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [https://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eggenweiler, H M]]	+	[[Category: Eggenweiler H-M]]
-	[[Category: Lehmann, M]]	+	[[Category: Lehmann M]]
-	[[Category: Musil, D]]	+	[[Category: Musil D]]
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Chaperone-chaperone inhibitor complex~~]]	+

OCA at 17:18, 14 August 2019

2019-08-14T17:18:44Z

←Older revision		Revision as of 17:18, 14 August 2019
Line 1:		Line 1:

-	==~~Kinetics~~ of ~~Hsp90 inhibitors (title to be refined)~~==	+	==Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations==
-	<StructureSection load='6fcj' size='340' side='right' caption='[[6fcj]], [[Resolution\|resolution]] 2.49Å' scene=''>	+	<StructureSection load='6fcj' size='340' side='right'caption='[[6fcj]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FCJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D4W:4-[2-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D4W:4-[2-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [http://pdbe.org/6fcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [http://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [http://pdbe.org/6fcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [http://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Eggenweiler, H M]]		[[Category: Eggenweiler, H M]]
	[[Category: Lehmann, M]]		[[Category: Lehmann, M]]

OCA at 08:20, 30 January 2019

2019-01-30T08:20:03Z

←Older revision		Revision as of 08:20, 30 January 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fcj is ~~ON HOLD~~	+	==Kinetics of Hsp90 inhibitors (title to be refined)==
-		+	<StructureSection load='6fcj' size='340' side='right' caption='[[6fcj]], [[Resolution\|resolution]] 2.49Å' scene=''>
-	~~Authors~~: ~~Musil~~, D., ~~Lehmann~~, M., ~~Eggenweiler~~, H.-M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FCJ FirstGlance]. <br>
-	~~Description~~: ~~Kinetics~~ of ~~Hsp90 inhibitors (title~~ to ~~be refined)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D4W:4-[2-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [http://pdbe.org/6fcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [http://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Eggenweiler, H M]]
		+	[[Category: Lehmann, M]]
	[[Category: Musil, D]]		[[Category: Musil, D]]
-	[[Category: ~~Lehmann, M~~]]	+	[[Category: Atp binding]]
-	[[Category: ~~Eggenweiler, H.~~-M]]	+	[[Category: Chaperone]]
		+	[[Category: Chaperone-chaperone inhibitor complex]]

OCA: Protected "6fcj" [edit=sysop:move=sysop]

2017-12-27T07:34:27Z

Protected "6fcj" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:34, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6fcj is ON HOLD Authors: Musil, D., Lehmann, M., Eggenweiler, H.-M. Description: Kinetics of Hsp90 inhibitors (title to be refined) [[Category: Unr...

2017-12-27T07:34:26Z

New page: '''Unreleased structure''' The entry 6fcj is ON HOLD Authors: Musil, D., Lehmann, M., Eggenweiler, H.-M. Description: Kinetics of Hsp90 inhibitors (title to be refined) [[Category: Unr...

New page

'''Unreleased structure'''

The entry 6fcj is ON HOLD

Authors: Musil, D., Lehmann, M., Eggenweiler, H.-M.

Description: Kinetics of Hsp90 inhibitors (title to be refined)
[[Category: Unreleased Structures]]
[[Category: Musil, D]]
[[Category: Lehmann, M]]
[[Category: Eggenweiler, H.-M]]