6fmp - Revision history

OCA at 07:48, 7 February 2024

2024-02-07T07:48:50Z

←Older revision		Revision as of 07:48, 7 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FMP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.92Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [https://pdbe.org/6fmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [https://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [https://pdbe.org/6fmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [https://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]		[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Noncovalent inhibitors of the Keap1-Nrf2 protein-protein interaction (PPI) have therapeutic potential in a range of disease states including neurodegenerative diseases (Parkinson's and Alzheimer's diseases), chronic obstructive pulmonary disease and various inflammatory conditions. By stalling Keap1-mediated ubiquitination of Nrf2, such compounds can enhance Nrf2 transcriptional activity and activate the expression of a range of genes with antioxidant response elements in their promoter regions. Keap1 inhibitors based on peptide and small-molecule templates have been identified. In this paper we develop the structure-activity relationships of the peptide series and identify a group of ligands incorporating unnatural amino acids that demonstrate improved binding affinity in fluorescence polarisation, differential scanning fluorimetry and isothermal titration calorimetry assays. These modified peptides have the potential for further development into peptidomimetic chemical probes to explore the role of Nrf2 in disease and as potential lead structures for drug development.
-
-	Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids.,Georgakopoulos ND, Talapatra SK, Gatliff J, Kozielski F, Wells G Chembiochem. 2018 Jun 21. doi: 10.1002/cbic.201800170. PMID:29927029<ref>PMID:29927029</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 6fmp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]		*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:57, 15 March 2023

2023-03-15T09:57:12Z

←Older revision		Revision as of 09:57, 15 March 2023
Line 1:		Line 1:

	==Keap1 - peptide complex==		==Keap1 - peptide complex==
-	<StructureSection load='6fmp' size='340' side='right' caption='[[6fmp]], [[Resolution\|resolution]] 2.92Å' scene=''>	+	<StructureSection load='6fmp' size='340' side='right'caption='[[6fmp]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FMP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [https://pdbe.org/6fmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [https://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [~~http~~://pdbe.org/6fmp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6fmp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fmp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Georgakopoulos, N D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kozielski, F~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Talapatra, S K~~]]	+	[[Category: Georgakopoulos ND]]
-	[[Category: ~~Wells, G~~]]	+	[[Category: Kozielski F]]
-	[[Category: ~~Inhibitor~~]]	+	[[Category: Talapatra SK]]
-	[[Category: ~~Keap1]]~~	+	[[Category: Wells G]]
-	~~[[Category: Kelch-domain]]~~	+
-	~~[[Category: Neurodegenerative]]~~	+
-	~~[[Category: Nrf2]]~~	+
-	~~[[Category: Peptide binding protein~~]]	+

OCA at 07:53, 12 September 2018

2018-09-12T07:53:59Z

←Older revision		Revision as of 07:53, 12 September 2018
Line 3:		Line 3:
	<StructureSection load='6fmp' size='340' side='right' caption='[[6fmp]], [[Resolution\|resolution]] 2.92Å' scene=''>		<StructureSection load='6fmp' size='340' side='right' caption='[[6fmp]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [http://pdbe.org/6fmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [http://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [http://pdbe.org/6fmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [http://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Georgakopoulos, N D]]		[[Category: Georgakopoulos, N D]]
	[[Category: Kozielski, F]]		[[Category: Kozielski, F]]

OCA at 21:53, 9 August 2018

2018-08-09T21:53:26Z

←Older revision		Revision as of 21:53, 9 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fmp is ~~ON HOLD~~	+	==Keap1 - peptide complex==
		+	<StructureSection load='6fmp' size='340' side='right' caption='[[6fmp]], [[Resolution\|resolution]] 2.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fmp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FMP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fmp OCA], [http://pdbe.org/6fmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fmp RCSB], [http://www.ebi.ac.uk/pdbsum/6fmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fmp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Noncovalent inhibitors of the Keap1-Nrf2 protein-protein interaction (PPI) have therapeutic potential in a range of disease states including neurodegenerative diseases (Parkinson's and Alzheimer's diseases), chronic obstructive pulmonary disease and various inflammatory conditions. By stalling Keap1-mediated ubiquitination of Nrf2, such compounds can enhance Nrf2 transcriptional activity and activate the expression of a range of genes with antioxidant response elements in their promoter regions. Keap1 inhibitors based on peptide and small-molecule templates have been identified. In this paper we develop the structure-activity relationships of the peptide series and identify a group of ligands incorporating unnatural amino acids that demonstrate improved binding affinity in fluorescence polarisation, differential scanning fluorimetry and isothermal titration calorimetry assays. These modified peptides have the potential for further development into peptidomimetic chemical probes to explore the role of Nrf2 in disease and as potential lead structures for drug development.

-	~~Authors~~:	+	Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids.,Georgakopoulos ND, Talapatra SK, Gatliff J, Kozielski F, Wells G Chembiochem. 2018 Jun 21. doi: 10.1002/cbic.201800170. PMID:29927029<ref>PMID:29927029</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6fmp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Georgakopoulos, N D]]
		+	[[Category: Kozielski, F]]
		+	[[Category: Talapatra, S K]]
		+	[[Category: Wells, G]]
		+	[[Category: Inhibitor]]
		+	[[Category: Keap1]]
		+	[[Category: Kelch-domain]]
		+	[[Category: Neurodegenerative]]
		+	[[Category: Nrf2]]
		+	[[Category: Peptide binding protein]]

OCA: Protected "6fmp" [edit=sysop:move=sysop]

2018-02-07T05:20:18Z

Protected "6fmp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 7 February 2018

OCA: New page: '''Unreleased structure''' The entry 6fmp is ON HOLD Authors: Description: Category: Unreleased Structures

2018-02-07T05:20:16Z

New page: '''Unreleased structure''' The entry 6fmp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fmp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]