6fu4 - Revision history

OCA at 21:02, 2 December 2018

2018-12-02T21:02:15Z

←Older revision		Revision as of 21:02, 2 December 2018
Line 3:		Line 3:
	<StructureSection load='6fu4' size='340' side='right' caption='[[6fu4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='6fu4' size='340' side='right' caption='[[6fu4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fu4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FU4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fu4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FU4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA2654 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu4 OCA], [http://pdbe.org/6fu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fu4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu4 OCA], [http://pdbe.org/6fu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fu4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu4 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histamine is a key biological signaling molecule. It acts as a neurotransmitter in the central and peripheral nervous systems and coordinates local inflammatory responses by modulating the activity of different immune cells. During inflammatory processes, including bacterial infections, neutrophils stimulate the production and release of histamine. Here, we report that the opportunistic human pathogen Pseudomonas aeruginosa exhibits chemotaxis toward histamine. This chemotactic response is mediated by the concerted action of the TlpQ, PctA, and PctC chemoreceptors, which display differing sensitivities to histamine. Low concentrations of histamine were sufficient to activate TlpQ, which binds histamine with an affinity of 639 nM. To explore this binding, we resolved the high-resolution structure of the TlpQ ligand binding domain in complex with histamine. It has an unusually large dCACHE domain and binds histamine through a highly negatively charged pocket at its membrane distal module. Chemotaxis to histamine may play a role in the virulence of P. aeruginosa by recruiting cells at the infection site and consequently modulating the expression of quorum-sensing-dependent virulence genes. TlpQ is the first bacterial histamine receptor to be described and greatly differs from human histamine receptors, indicating that eukaryotes and bacteria have pursued different strategies for histamine recognition.IMPORTANCE Genome analyses indicate that many bacteria possess an elevated number of chemoreceptors, suggesting that these species are able to perform chemotaxis to a wide variety of compounds. The scientific community is now only beginning to explore this diversity and to elucidate the corresponding physiological relevance. The discovery of histamine chemotaxis in the human pathogen Pseudomonas aeruginosa provides insight into tactic movements that occur within the host. Since histamine is released in response to bacterial pathogens, histamine chemotaxis may permit bacterial migration and accumulation at infection sites, potentially modulating, in turn, quorum-sensing-mediated processes and the expression of virulence genes. As a consequence, the modulation of histamine chemotaxis by signal analogues may result in alterations of the bacterial virulence. As the first report of bacterial histamine chemotaxis, this study lays the foundation for the exploration of the physiological relevance of histamine chemotaxis and its role in pathogenicity.
		+
		+	High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa.,Corral-Lugo A, Matilla MA, Martin-Mora D, Silva Jimenez H, Mesa Torres N, Kato J, Hida A, Oku S, Conejero-Muriel M, Gavira JA, Krell T MBio. 2018 Nov 13;9(6). pii: mBio.01894-18. doi: 10.1128/mBio.01894-18. PMID:30425146<ref>PMID:30425146</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fu4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pseae]]
	[[Category: Conejero-Muriel, M]]		[[Category: Conejero-Muriel, M]]
	[[Category: Corral-Lugo, A]]		[[Category: Corral-Lugo, A]]

OCA at 05:37, 16 May 2018

2018-05-16T05:37:39Z

←Older revision		Revision as of 05:37, 16 May 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6fu4 ~~is ON HOLD~~	+	==Ligand binding domain (LBD) of the p. aeruginosa histamine receptor TlpQ==
-		+	<StructureSection load='6fu4' size='340' side='right' caption='[[6fu4]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors~~: ~~Gavira, J~~.A.~~, Krell, T~~.~~, Conejero~~-~~Muriel, M~~.~~, Corral~~-~~Lugo, A~~., ~~Matilla~~, M.A.~~, Silva Jimenez, H~~.~~, Mesa Torres, N~~., ~~Martin~~-~~Mora~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fu4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FU4 FirstGlance]. <br>
-	~~Description~~: ~~Ligand binding domain (LBD) of the p~~. ~~aeruginosa histamine receptor TlpQ~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures]~~]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Mesa Torres~~, N]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu4 OCA], [http://pdbe.org/6fu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fu4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu4 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Conejero-Muriel, M]]
	[[Category: Corral-Lugo, A]]		[[Category: Corral-Lugo, A]]
-	[[Category: ~~Matilla~~, M.A]]	+	[[Category: Gavira, J A]]
-	[[Category: ~~Conejero-Muriel~~, M]]	+	[[Category: Jimenez, H Silva]]
-	[[Category: ~~Gavira~~, ~~J.A]]~~	+	[[Category: Krell, T]]
-	~~[[Category: Silva Jimenez, H~~]]	+
	[[Category: Martin-Mora, D]]		[[Category: Martin-Mora, D]]
-	[[Category: ~~Krell~~, T]]	+	[[Category: Matilla, M A]]
		+	[[Category: Torres, N Mesa]]
		+	[[Category: Chemoreceptor]]
		+	[[Category: Chemotaxis]]
		+	[[Category: Histamine]]
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Signaling protein]]

OCA: Protected "6fu4" [edit=sysop:move=sysop]

2018-03-08T03:56:53Z

Protected "6fu4" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:56, 8 March 2018

OCA: New page: '''Unreleased structure''' The entry 6fu4 is ON HOLD Authors: Gavira, J.A., Krell, T., Conejero-Muriel, M., Corral-Lugo, A., Matilla, M.A., Silva Jimenez, H., Mesa Torres, N., Martin-Mo...

2018-03-08T03:56:52Z

New page: '''Unreleased structure''' The entry 6fu4 is ON HOLD Authors: Gavira, J.A., Krell, T., Conejero-Muriel, M., Corral-Lugo, A., Matilla, M.A., Silva Jimenez, H., Mesa Torres, N., Martin-Mo...

New page

'''Unreleased structure'''

The entry 6fu4 is ON HOLD

Authors: Gavira, J.A., Krell, T., Conejero-Muriel, M., Corral-Lugo, A., Matilla, M.A., Silva Jimenez, H., Mesa Torres, N., Martin-Mora, D.

Description: Ligand binding domain (LBD) of the p. aeruginosa histamine receptor TlpQ
[[Category: Unreleased Structures]]
[[Category: Mesa Torres, N]]
[[Category: Corral-Lugo, A]]
[[Category: Matilla, M.A]]
[[Category: Conejero-Muriel, M]]
[[Category: Gavira, J.A]]
[[Category: Silva Jimenez, H]]
[[Category: Martin-Mora, D]]
[[Category: Krell, T]]