6fyd - Revision history

OCA at 06:02, 16 May 2018

2018-05-16T06:02:37Z

←Older revision		Revision as of 06:02, 16 May 2018
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	<StructureSection load='6fyd' size='340' side='right' caption='[[6fyd]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='6fyd' size='340' side='right' caption='[[6fyd]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fyd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/'streptomyces_maritimus' 'streptomyces maritimus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FYD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6foq\|6foq]], [[6fow\|6fow]], [[6fp3\|6fp3]], [[6fy8\|6fy8]], [[6fy9\|6fy9]], [[6fya\|6fya]], [[6fyb\|6fyb]], [[6fyc\|6fyc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6foq\|6foq]], [[6fow\|6fow]], [[6fp3\|6fp3]], [[6fy8\|6fy8]], [[6fy9\|6fy9]], [[6fya\|6fya]], [[6fyb\|6fyb]], [[6fyc\|6fyc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">encM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=115828 'Streptomyces maritimus'])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fyd OCA], [http://pdbe.org/6fyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fyd RCSB], [http://www.ebi.ac.uk/pdbsum/6fyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fyd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fyd OCA], [http://pdbe.org/6fyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fyd RCSB], [http://www.ebi.ac.uk/pdbsum/6fyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fyd ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Streptomyces maritimus]]
	[[Category: Saleem-Batcha, R]]		[[Category: Saleem-Batcha, R]]
	[[Category: Teufel, R]]		[[Category: Teufel, R]]

OCA at 08:17, 2 May 2018

2018-05-02T08:17:33Z

←Older revision		Revision as of 08:17, 2 May 2018
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-	'''Unreleased structure'''

-	The ~~entry~~ 6fyd is ~~ON HOLD~~	+	==The crystal structure of EncM T139V mutant==
		+	<StructureSection load='6fyd' size='340' side='right' caption='[[6fyd]], [[Resolution\|resolution]] 1.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FYD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6foq\|6foq]], [[6fow\|6fow]], [[6fp3\|6fp3]], [[6fy8\|6fy8]], [[6fy9\|6fy9]], [[6fya\|6fya]], [[6fyb\|6fyb]], [[6fyc\|6fyc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fyd OCA], [http://pdbe.org/6fyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fyd RCSB], [http://www.ebi.ac.uk/pdbsum/6fyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fyd ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The reactions of enzymes and cofactors with gaseous molecules such as dioxygen (O2) are challenging to study and remain among the most contentious subjects in biochemistry. To date, it is largely enigmatic how enzymes control and fine-tune their reactions with O2, as exemplified by the ubiquitous flavin-dependent enzymes that commonly facilitate redox chemistry such as the oxygenation of organic substrates. Here we employ O2-pressurized X-ray crystallography and quantum mechanical calculations to reveal how the precise positioning of O2 within a flavoenzyme's active site enables the regiospecific formation of a covalent flavin-oxygen adduct and oxygenating species (i.e., the flavin-N5-oxide) by mimicking a critical transition state. This study unambiguously demonstrates how enzymes may control the O2 functionalization of an organic cofactor as prerequisite for oxidative catalysis. Our work thus illustrates how O2 reactivity can be harnessed in an enzymatic environment and provides crucial knowledge for future rational design of O2-reactive enzymes.

-	~~Authors:~~ Saleem-Batcha, R., ~~Teufel~~, R.	+	Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.,Saleem-Batcha R, Stull F, Sanders JN, Moore BS, Palfey BA, Houk KN, Teufel R Proc Natl Acad Sci U S A. 2018 Apr 23. pii: 1801189115. doi:, 10.1073/pnas.1801189115. PMID:29686059<ref>PMID:29686059</ref>

-	~~Description: The crystal structure~~ of ~~EncM T139V mutant~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Teufel, R]]~~	+	<div class="pdbe-citations 6fyd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Saleem-Batcha, R]]		[[Category: Saleem-Batcha, R]]
		+	[[Category: Teufel, R]]
		+	[[Category: Encm]]
		+	[[Category: Fad]]
		+	[[Category: Flavin-n5-oxide]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Oxygen binding]]
		+	[[Category: Oxygenating species]]

OCA: Protected "6fyd" [edit=sysop:move=sysop]

2018-03-21T06:20:45Z

Protected "6fyd" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 6fyd is ON HOLD Authors: Saleem-Batcha, R., Teufel, R. Description: The crystal structure of EncM T139V mutant Category: Unreleased Structures ...

2018-03-21T06:20:43Z

New page: '''Unreleased structure''' The entry 6fyd is ON HOLD Authors: Saleem-Batcha, R., Teufel, R. Description: The crystal structure of EncM T139V mutant Category: Unreleased Structures ...

New page

'''Unreleased structure'''

The entry 6fyd is ON HOLD

Authors: Saleem-Batcha, R., Teufel, R.

Description: The crystal structure of EncM T139V mutant
[[Category: Unreleased Structures]]
[[Category: Teufel, R]]
[[Category: Saleem-Batcha, R]]