6g6b - Revision history

OCA at 12:33, 9 May 2024

2024-05-09T12:33:52Z

←Older revision		Revision as of 12:33, 9 May 2024
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	==Crystal structure of a parallel six-helix coiled coil CC-Type2-LL-L17Q==		==Crystal structure of a parallel six-helix coiled coil CC-Type2-LL-L17Q==
-	<StructureSection load='6g6b' size='340' side='right' caption='[[6g6b]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='6g6b' size='340' side='right'caption='[[6g6b]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g6b]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6G6B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g6b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G6B FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6g6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6b OCA], [~~http~~://pdbe.org/6g6b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6g6b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6g6b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6b ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6b OCA], [https://pdbe.org/6g6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g6b RCSB], [https://www.ebi.ac.uk/pdbsum/6g6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6b ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brady, R L]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Rhys, G G]]~~	+
-	~~[[Category: Woolfson, D N]]~~	+
-	~~[[Category: Alpha-helical bundle]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: De novo]]~~	+
-	~~[[Category: De novo protein~~]]	+
	[[Category: Synthetic construct]]		[[Category: Synthetic construct]]
		+	[[Category: Brady RL]]
		+	[[Category: Rhys GG]]
		+	[[Category: Woolfson DN]]

OCA at 08:06, 17 October 2018

2018-10-17T08:06:12Z

←Older revision		Revision as of 08:06, 17 October 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6g6b is ~~ON HOLD~~	+	==Crystal structure of a parallel six-helix coiled coil CC-Type2-LL-L17Q==
		+	<StructureSection load='6g6b' size='340' side='right' caption='[[6g6b]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6g6b]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G6B FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6b OCA], [http://pdbe.org/6g6b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g6b RCSB], [http://www.ebi.ac.uk/pdbsum/6g6b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6b ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In coiled-coil (CC) protein structures alpha-helices wrap around one another to form rope-like assemblies. Most natural and designed CCs have two-four helices and cyclic (Cn) or dihedral (Dn) symmetry. Increasingly, CCs with five or more helices are being reported. A subset of these higher-order CCs is of interest as they have accessible central channels that can be functionalised; they are alpha-helical barrels. These extended cavities are surprising given the drive to maximise buried hydrophobic surfaces during protein folding and assembly in water. Here, we show that alpha-helical barrels can be maintained by the strategic placement of beta-branched aliphatic residues lining the lumen. Otherwise, the structures collapse or adjust to give more-complex multi-helix assemblies without Cn or Dn symmetry. Nonetheless, the structural hallmark of CCs-namely, knobs-into-holes packing of side chains between helices-is maintained leading to classes of CCs hitherto unobserved in nature or accessed by design.

-	~~Authors~~:	+	Maintaining and breaking symmetry in homomeric coiled-coil assemblies.,Rhys GG, Wood CW, Lang EJM, Mulholland AJ, Brady RL, Thomson AR, Woolfson DN Nat Commun. 2018 Oct 8;9(1):4132. doi: 10.1038/s41467-018-06391-y. PMID:30297707<ref>PMID:30297707</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6g6b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brady, R L]]
		+	[[Category: Rhys, G G]]
		+	[[Category: Woolfson, D N]]
		+	[[Category: Alpha-helical bundle]]
		+	[[Category: Coiled coil]]
		+	[[Category: De novo]]
		+	[[Category: De novo protein]]
		+	[[Category: Synthetic construct]]

OCA: Protected "6g6b" [edit=sysop:move=sysop]

2018-04-11T12:39:32Z

Protected "6g6b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:39, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g6b is ON HOLD Authors: Description: Category: Unreleased Structures

2018-04-11T12:39:31Z

New page: '''Unreleased structure''' The entry 6g6b is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g6b is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]