OCA at 12:39, 13 March 2019

2019-03-13T12:39:32Z

←Older revision		Revision as of 12:39, 13 March 2019
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	==Structure of H-2Kb with dipeptide GL==		==Structure of H-2Kb with dipeptide GL==
-	<StructureSection load='6gb6' size='340' side='right' caption='[[6gb6]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='6gb6' size='340' side='right'caption='[[6gb6]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gb6]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GB6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gb6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GB6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-K1, H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gb6 OCA], [http://pdbe.org/6gb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gb6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gb6 OCA], [http://pdbe.org/6gb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.		[[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MHC-I epitope presentation to CD8(+) T cells is directly dependent on peptide loading and selection during antigen processing. However, the exact molecular bases underlying peptide selection and binding by MHC-I remain largely unknown. Within the peptide-loading complex, the peptide editor tapasin is key to the selection of MHC-I-bound peptides. Here, we have determined an ensemble of crystal structures of MHC-I in complex with the peptide exchange-associated dipeptide GL, as well as the tapasin-associated scoop loop, alone or in combination with candidate epitopes. These results combined with mutation analyses allow us to propose a molecular model underlying MHC-I peptide selection by tapasin. The N termini of bound peptides most probably bind first in the N-terminal and middle region of the MHC-I peptide binding cleft, upon which the peptide C termini are tested for their capacity to dislodge the tapasin scoop loop from the F pocket of the MHC-I cleft. Our results also indicate important differences in peptide selection between different MHC-I alleles.
		+
		+	Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.,Hafstrand I, Sayitoglu EC, Apavaloaei A, Josey BJ, Sun R, Han X, Pellegrino S, Ozkazanc D, Potens R, Janssen L, Nilvebrant J, Nygren PA, Sandalova T, Springer S, Georgoudaki AM, Duru AD, Achour A Proc Natl Acad Sci U S A. 2019 Feb 26. pii: 1807656116. doi:, 10.1073/pnas.1807656116. PMID:30808808<ref>PMID:30808808</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6gb6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Hafstrand, I]]		[[Category: Hafstrand, I]]

OCA at 07:28, 6 March 2019

2019-03-06T07:28:04Z

←Older revision		Revision as of 07:28, 6 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6gb6 ~~is ON HOLD~~ ~~until Paper Publication~~	+	==Structure of H-2Kb with dipeptide GL==
-		+	<StructureSection load='6gb6' size='340' side='right' caption='[[6gb6]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6gb6]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GB6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gb6 OCA], [http://pdbe.org/6gb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gb6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Achour, A]]
		+	[[Category: Hafstrand, I]]
		+	[[Category: Sandalova, T]]
		+	[[Category: H-2kb]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc]]
		+	[[Category: Mhc-i]]

OCA: Protected "6gb6" [edit=sysop:move=sysop]

2018-04-25T04:18:23Z

Protected "6gb6" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 25 April 2018

OCA: New page: '''Unreleased structure''' The entry 6gb6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2018-04-25T04:18:22Z

New page: '''Unreleased structure''' The entry 6gb6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6gb6 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6gb6 - Revision history

OCA at 12:39, 13 March 2019

OCA at 07:28, 6 March 2019

OCA: Protected "6gb6" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6gb6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures