6gza - Revision history

OCA at 08:58, 19 December 2018

2018-12-19T08:58:46Z

←Older revision		Revision as of 08:58, 19 December 2018
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	<StructureSection load='6gza' size='340' side='right' caption='[[6gza]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='6gza' size='340' side='right' caption='[[6gza]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gza]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mlv Mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11786 MLV])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gza OCA], [http://pdbe.org/6gza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gza RCSB], [http://www.ebi.ac.uk/pdbsum/6gza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gza ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gza OCA], [http://pdbe.org/6gza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gza RCSB], [http://www.ebi.ac.uk/pdbsum/6gza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gza ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mlv]]
	[[Category: Briggs, J A.G]]		[[Category: Briggs, J A.G]]
	[[Category: Dolezal, M]]		[[Category: Dolezal, M]]

OCA at 06:45, 5 December 2018

2018-12-05T06:45:45Z

←Older revision		Revision as of 06:45, 5 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6gza is ~~ON HOLD~~	+	==Structure of murine leukemia virus capsid C-terminal domain==
		+	<StructureSection load='6gza' size='340' side='right' caption='[[6gza]], [[Resolution\|resolution]] 1.89Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6gza]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gza OCA], [http://pdbe.org/6gza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gza RCSB], [http://www.ebi.ac.uk/pdbsum/6gza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gza ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Retroviruses assemble and bud from infected cells in an immature form and require proteolytic maturation for infectivity. The CA (capsid) domains of the Gag polyproteins assemble a protein lattice as a truncated sphere in the immature virion. Proteolytic cleavage of Gag induces dramatic structural rearrangements; a subset of cleaved CA subsequently assembles into the mature core, whose architecture varies among retroviruses. Murine leukemia virus (MLV) is the prototypical gamma-retrovirus and serves as the basis of retroviral vectors, but the structure of the MLV CA layer is unknown. Here we have combined X-ray crystallography with cryoelectron tomography to determine the structures of immature and mature MLV CA layers within authentic viral particles. This reveals the structural changes associated with maturation, and, by comparison with HIV-1, uncovers conserved and variable features. In contrast to HIV-1, most MLV CA is used for assembly of the mature core, which adopts variable, multilayered morphologies and does not form a closed structure. Unlike in HIV-1, there is similarity between protein-protein interfaces in the immature MLV CA layer and those in the mature CA layer, and structural maturation of MLV could be achieved through domain rotations that largely maintain hexameric interactions. Nevertheless, the dramatic architectural change on maturation indicates that extensive disassembly and reassembly are required for mature core growth. The core morphology suggests that wrapping of the genome in CA sheets may be sufficient to protect the MLV ribonucleoprotein during cell entry.

-	~~Authors~~:	+	Structure and architecture of immature and mature murine leukemia virus capsids.,Qu K, Glass B, Dolezal M, Schur FKM, Murciano B, Rein A, Rumlova M, Ruml T, Krausslich HG, Briggs JAG Proc Natl Acad Sci U S A. 2018 Nov 26. pii: 1811580115. doi:, 10.1073/pnas.1811580115. PMID:30478053<ref>PMID:30478053</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6gza" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Briggs, J A.G]]
		+	[[Category: Dolezal, M]]
		+	[[Category: Murciano, B]]
		+	[[Category: Qu, K]]
		+	[[Category: Ruml, T]]
		+	[[Category: Rumlova, M]]
		+	[[Category: Schur, F K.M]]
		+	[[Category: Capsid]]
		+	[[Category: Cobalt]]
		+	[[Category: Dimer]]
		+	[[Category: Viral protein]]

OCA: Protected "6gza" [edit=sysop:move=sysop]

2018-07-11T04:18:03Z

Protected "6gza" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 11 July 2018

OCA: New page: '''Unreleased structure''' The entry 6gza is ON HOLD Authors: Description: Category: Unreleased Structures

2018-07-11T04:18:02Z

New page: '''Unreleased structure''' The entry 6gza is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6gza is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]