6h0o - Revision history

OCA: Redirecting to 6sk9

2020-06-17T10:01:14Z

Redirecting to 6sk9

←Older revision		Revision as of 10:01, 17 June 2020
Line 1:		Line 1:
-		+	#REDIRECT [[6sk9]] This PDB entry is obsolete and replaced by 6sk9
-	~~==Nek2 bound to purine inhibitor==~~	+
-	~~<StructureSection load='6h0o' size='340' side='right' caption='~~[[~~6h0o]], [[Resolution\|resolution]] 2.00Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[6h0o~~]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0O FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9N:3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide'>F9N</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6gt1\|6gt1]]</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0o OCA], [http://pdbe.org/6h0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0o RCSB], [http://www.ebi.ac.uk/pdbsum/6h0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0o ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/NEK2_HUMAN NEK2_HUMAN]] Protein kinase which is involved in the control of centrosome separation~~ and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.<ref>PMID:11742531</ref> <ref>PMID:14978040</ref> <ref>PMID:12857871</ref> <ref>PMID:15358203</ref> <ref>PMID:15388344</ref> <ref>PMID:15161910</ref> <ref>PMID:17283141</ref> <ref>PMID:17621308</ref> <ref>PMID:17626005</ref> <ref>PMID:18086858</ref> <ref>PMID:18297113</ref> <ref>PMID:20034488</ref> <ref>PMID:21076410</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+
-	~~[[Category: Bayliss, R W]]~~	+
-	~~[[Category: Bhatia, C]]~~	+
-	~~[[Category: Byrne, M J]]~~	+
-	~~[[Category: Cunnison, R F]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Mitosis]]~~	+

OCA at 06:20, 22 August 2018

2018-08-22T06:20:52Z

←Older revision		Revision as of 06:20, 22 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6h0o is ~~ON HOLD~~	+	==Nek2 bound to purine inhibitor==
-		+	<StructureSection load='6h0o' size='340' side='right' caption='[[6h0o]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~: ~~Byrne~~, M.J., ~~Cunnison, R~~.F., ~~Bhatia~~, C., ~~Bayliss~~, R.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6h0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0O FirstGlance]. <br>
-	~~Description~~: ~~Nek2 bound~~ to ~~purine inhibitor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9N:3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide'>F9N</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6gt1\|6gt1]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0o OCA], [http://pdbe.org/6h0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0o RCSB], [http://www.ebi.ac.uk/pdbsum/6h0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0o ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NEK2_HUMAN NEK2_HUMAN]] Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.<ref>PMID:11742531</ref> <ref>PMID:14978040</ref> <ref>PMID:12857871</ref> <ref>PMID:15358203</ref> <ref>PMID:15388344</ref> <ref>PMID:15161910</ref> <ref>PMID:17283141</ref> <ref>PMID:17621308</ref> <ref>PMID:17626005</ref> <ref>PMID:18086858</ref> <ref>PMID:18297113</ref> <ref>PMID:20034488</ref> <ref>PMID:21076410</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Bayliss, R W]]
	[[Category: Bhatia, C]]		[[Category: Bhatia, C]]
-	[[Category: ~~Bayliss~~, ~~R.W~~]]	+	[[Category: Byrne, M J]]
-	[[Category: ~~Byrne~~, ~~M.J~~]]	+	[[Category: Cunnison, R F]]
-	[[Category: ~~Cunnison, R.F~~]]	+	[[Category: Cell cycle]]
		+	[[Category: Kinase]]
		+	[[Category: Mitosis]]

OCA at 06:01, 25 July 2018

2018-07-25T06:01:41Z

←Older revision		Revision as of 06:01, 25 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6h0o is ON HOLD ~~until sometime in the future~~	+	The entry 6h0o is ON HOLD

	Authors: Byrne, M.J., Cunnison, R.F., Bhatia, C., Bayliss, R.W.		Authors: Byrne, M.J., Cunnison, R.F., Bhatia, C., Bayliss, R.W.

-	Description: ~~Nek7~~ bound to purine inhibitor	+	Description: Nek2 bound to purine inhibitor
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Bhatia, C]]		[[Category: Bhatia, C]]

OCA: Protected "6h0o" [edit=sysop:move=sysop]

2018-07-18T05:49:41Z

Protected "6h0o" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:49, 18 July 2018

OCA: New page: '''Unreleased structure''' The entry 6h0o is ON HOLD until sometime in the future Authors: Byrne, M.J., Cunnison, R.F., Bhatia, C., Bayliss, R.W. Description: Nek7 bound to purine inhi...

2018-07-18T05:49:38Z

New page: '''Unreleased structure''' The entry 6h0o is ON HOLD until sometime in the future Authors: Byrne, M.J., Cunnison, R.F., Bhatia, C., Bayliss, R.W. Description: Nek7 bound to purine inhi...

New page

'''Unreleased structure'''

The entry 6h0o is ON HOLD until sometime in the future

Authors: Byrne, M.J., Cunnison, R.F., Bhatia, C., Bayliss, R.W.

Description: Nek7 bound to purine inhibitor
[[Category: Unreleased Structures]]
[[Category: Bhatia, C]]
[[Category: Bayliss, R.W]]
[[Category: Byrne, M.J]]
[[Category: Cunnison, R.F]]