6hbm - Revision history

OCA at 06:48, 3 July 2019

2019-07-03T06:48:51Z

←Older revision		Revision as of 06:48, 3 July 2019
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	<StructureSection load='6hbm' size='340' side='right'caption='[[6hbm]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='6hbm' size='340' side='right'caption='[[6hbm]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hbm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HBM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hb0\|6hb0]], [[6hbo\|6hbo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hb0\|6hb0]], [[6hbo\|6hbo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_1712 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hbm OCA], [http://pdbe.org/6hbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hbm RCSB], [http://www.ebi.ac.uk/pdbsum/6hbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hbm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hbm OCA], [http://pdbe.org/6hbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hbm RCSB], [http://www.ebi.ac.uk/pdbsum/6hbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hbm ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycs2]]
	[[Category: Einsle, O]]		[[Category: Einsle, O]]
	[[Category: Jessen-Trefzer, C]]		[[Category: Jessen-Trefzer, C]]

OCA at 08:48, 1 May 2019

2019-05-01T08:48:37Z

←Older revision		Revision as of 08:48, 1 May 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hbm is ~~ON HOLD~~	+	==Crystal structure of MSMEG_1712 from Mycobacterium smegmatis in complex with alpha-L-arabinofuranose==
		+	<StructureSection load='6hbm' size='340' side='right'caption='[[6hbm]], [[Resolution\|resolution]] 2.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hbm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HBM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6hb0\|6hb0]], [[6hbo\|6hbo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hbm OCA], [http://pdbe.org/6hbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hbm RCSB], [http://www.ebi.ac.uk/pdbsum/6hbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hbm ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nutrient uptake is essential for survival of organisms, and carbohydrates serve as a crucial carbon and energy source for most microorganisms. Given the importance of mycobacteria as human pathogens a detailed knowledge of carbohydrate uptake transporters is highly desirable, but currently available information is severely limited and mainly based on in silico analyses. Moreover, there is only very little data available on the in vitro characterization of carbohydrate transporters from mycobacterial species. To overcome these significant limitations there is a strong demand for innovative approaches to experimentally match substrates to ATP-binding cassette (ABC) transporters in a straightforward manner. Our study focuses on the model organism Mycobacterium smegmatis and identifies a mycobacterial ABC transport system based on a rapid label-free mass spectrometry lipoproteomics assay with broad applicability. Further validation and X-ray structure analyses reveal a highly selective mycobacterial L-arabinose uptake system.

-	~~Authors: Li~~, M~~., Mueller~~, C., ~~Einsle~~, O., Jessen-Trefzer, C.	+	Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol.,Li M, Muller C, Frohlich K, Gorka O, Zhang L, Gross O, Schilling O, Einsle O, Jessen-Trefzer C Cell Chem Biol. 2019 Mar 15. pii: S2451-9456(19)30079-0. doi:, 10.1016/j.chembiol.2019.03.002. PMID:31006617<ref>PMID:31006617</ref>

-	~~Description: Crystal structure~~ of ~~MSMEG_1712 from Mycobacterium smegmatis in complex with alpha~~-L-~~arabinofuranose~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Mueller, C]]~~	+	<div class="pdbe-citations 6hbm" style="background-color:#fffaf0;"></div>
-	~~[[Category: Li, M]]~~	+	== References ==
-	[[Category: ~~Jessen-Trefzer, C~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Einsle, O]]		[[Category: Einsle, O]]
		+	[[Category: Jessen-Trefzer, C]]
		+	[[Category: Li, M]]
		+	[[Category: Mueller, C]]
		+	[[Category: Periplasmic binding protein]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "6hbm" [edit=sysop:move=sysop]

2018-08-22T04:54:50Z

Protected "6hbm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:54, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6hbm is ON HOLD Authors: Li, M., Mueller, C., Einsle, O., Jessen-Trefzer, C. Description: Crystal structure of MSMEG_1712 from Mycobacterium smegma...

2018-08-22T04:54:49Z

New page: '''Unreleased structure''' The entry 6hbm is ON HOLD Authors: Li, M., Mueller, C., Einsle, O., Jessen-Trefzer, C. Description: Crystal structure of MSMEG_1712 from Mycobacterium smegma...

New page

'''Unreleased structure'''

The entry 6hbm is ON HOLD

Authors: Li, M., Mueller, C., Einsle, O., Jessen-Trefzer, C.

Description: Crystal structure of MSMEG_1712 from Mycobacterium smegmatis in complex with alpha-L-arabinofuranose
[[Category: Unreleased Structures]]
[[Category: Mueller, C]]
[[Category: Li, M]]
[[Category: Jessen-Trefzer, C]]
[[Category: Einsle, O]]