6hfc - Revision history

OCA at 07:49, 7 February 2024

2024-02-07T07:49:15Z

←Older revision		Revision as of 07:49, 7 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/tern/Australia/G70C/1975(H11N9)) Influenza A virus (A/tern/Australia/G70C/1975(H11N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/tern/Australia/G70C/1975(H11N9)) Influenza A virus (A/tern/Australia/G70C/1975(H11N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.29Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hfc OCA], [https://pdbe.org/6hfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hfc RCSB], [https://www.ebi.ac.uk/pdbsum/6hfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hfc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hfc OCA], [https://pdbe.org/6hfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hfc RCSB], [https://www.ebi.ac.uk/pdbsum/6hfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hfc ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:57, 15 March 2023

2023-03-15T09:57:38Z

←Older revision		Revision as of 09:57, 15 March 2023
Line 1:		Line 1:

	==Influenza A Virus N9 Neuraminidase Native (Tern).==		==Influenza A Virus N9 Neuraminidase Native (Tern).==
-	<StructureSection load='6hfc' size='340' side='right' caption='[[6hfc]], [[Resolution\|resolution]] 1.29Å' scene=''>	+	<StructureSection load='6hfc' size='340' side='right'caption='[[6hfc]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~I75a5 I75a5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6HFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/tern/Australia/G70C/1975(H11N9)) Influenza A virus (A/tern/Australia/G70C/1975(H11N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hfc OCA], [https://pdbe.org/6hfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hfc RCSB], [https://www.ebi.ac.uk/pdbsum/6hfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hfc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hfc OCA], [~~http~~://pdbe.org/6hfc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hfc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hfc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hfc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.	+	[https://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
		+
		+	==See Also==
		+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Exo-alpha-sialidase]]~~	+	[[Category: Large Structures]]
-	~~[[Category: I75a5~~]]	+	[[Category: Garman EF]]
-	[[Category: Garman~~, E F~~]]	+	[[Category: Hobbs JR]]
-	[[Category: Hobbs~~, J R~~]]	+	[[Category: Kuhn P]]
-	[[Category: Kuhn, P]]	+	[[Category: Laver WG]]
-	[[Category: Laver~~, W G~~]]	+	[[Category: Murray JW]]
-	[[Category: Murray~~, J W~~]]	+	[[Category: Salinger MT]]
-	[[Category: Salinger~~, M T]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Influenza]]~~	+
-	~~[[Category: N9]]~~	+
-	~~[[Category: Native]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 10:36, 5 September 2018

2018-09-05T10:36:48Z

←Older revision		Revision as of 10:36, 5 September 2018
Line 3:		Line 3:
	<StructureSection load='6hfc' size='340' side='right' caption='[[6hfc]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='6hfc' size='340' side='right' caption='[[6hfc]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(strain_a/tern/australia/g70c/1975_h11n9) Influenza a virus (strain a/tern/australia/g70c/1975 h11n9)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
Line 13:		Line 13:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: I75a5]]
	[[Category: Garman, E F]]		[[Category: Garman, E F]]
	[[Category: Hobbs, J R]]		[[Category: Hobbs, J R]]
	[[Category: Kuhn, P]]		[[Category: Kuhn, P]]
	[[Category: Laver, W G]]		[[Category: Laver, W G]]
-	[[Category: Murray, J M]]	+	[[Category: Murray, J W]]
	[[Category: Salinger, M T]]		[[Category: Salinger, M T]]
	[[Category: Complex]]		[[Category: Complex]]

OCA: Protected "6hfc" [edit=sysop:move=sysop]

2018-08-29T07:38:32Z

Protected "6hfc" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:38, 29 August 2018

OCA: New page: ==Influenza A Virus N9 Neuraminidase Native (Tern).== == Structur...

2018-08-29T07:38:31Z

New page: ==Influenza A Virus N9 Neuraminidase Native (Tern).== <StructureSection load='6hfc' size='340' side='right' caption='6hfc, resolution 1.29Å' scene=''> == Structur...

New page

==Influenza A Virus N9 Neuraminidase Native (Tern).==
<StructureSection load='6hfc' size='340' side='right' caption='[[6hfc]], [[Resolution|resolution]] 1.29Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6hfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(strain_a/tern/australia/g70c/1975_h11n9) Influenza a virus (strain a/tern/australia/g70c/1975 h11n9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HFC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HFC FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hfc OCA], [http://pdbe.org/6hfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hfc RCSB], [http://www.ebi.ac.uk/pdbsum/6hfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hfc ProSAT]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
__TOC__
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Garman, E F]]
[[Category: Hobbs, J R]]
[[Category: Kuhn, P]]
[[Category: Laver, W G]]
[[Category: Murray, J M]]
[[Category: Salinger, M T]]
[[Category: Complex]]
[[Category: Enzyme]]
[[Category: Hydrolase]]
[[Category: Influenza]]
[[Category: N9]]
[[Category: Native]]
[[Category: Neuraminidase]]
[[Category: Virus]]