6hig - Revision history

OCA at 06:22, 10 July 2019

2019-07-10T06:22:31Z

←Older revision		Revision as of 06:22, 10 July 2019
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	<StructureSection load='6hig' size='340' side='right'caption='[[6hig]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6hig' size='340' side='right'caption='[[6hig]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hig]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hig]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hig OCA], [http://pdbe.org/6hig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hig RCSB], [http://www.ebi.ac.uk/pdbsum/6hig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hig ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hig OCA], [http://pdbe.org/6hig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hig RCSB], [http://www.ebi.ac.uk/pdbsum/6hig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hig ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Fenwick, C]]		[[Category: Fenwick, C]]
	[[Category: Loredo-Varela, J L]]		[[Category: Loredo-Varela, J L]]

OCA at 22:45, 5 June 2019

2019-06-05T22:45:10Z

←Older revision		Revision as of 22:45, 5 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6hig is ~~ON HOLD~~	+	==hPD-1/NBO1a Fab complex==
		+	<StructureSection load='6hig' size='340' side='right'caption='[[6hig]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6hig]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIG FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hig OCA], [http://pdbe.org/6hig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hig RCSB], [http://www.ebi.ac.uk/pdbsum/6hig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hig ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[http://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Classical antagonistic antibodies (Abs) targeting PD-1, such as pembrolizumab and nivolumab, act through blockade of the PD-1-PDL-1 interaction. Here, we have identified novel antagonistic anti-PD-1 Abs not blocking the PD-1-PDL-1 interaction. The nonblocking Abs recognize epitopes on PD-1 located on the opposing face of the PDL-1 interaction and overlap with a newly identified evolutionarily conserved patch. These nonblocking Abs act predominantly through the CD28 coreceptor. Importantly, a combination of blocking and nonblocking Abs synergize in the functional recovery of antigen-specific exhausted CD8 T cells. Interestingly, nonblocking anti-PD-1 Abs have equivalent antitumor activity compared with blocker Abs in two mouse tumor models, and combination therapy using both classes of Abs enhanced tumor suppression in the mouse immunogenic tumor model. The identification of the novel nonblocker anti-PD-1 Abs and their synergy with classical blocker Abs may be instrumental in potentiating immunotherapy strategies and antitumor activity.

-	~~Authors~~:	+	Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway.,Fenwick C, Loredo-Varela JL, Joo V, Pellaton C, Farina A, Rajah N, Esteves-Leuenberger L, Decaillon T, Suffiotti M, Noto A, Ohmiti K, Gottardo R, Weissenhorn W, Pantaleo G J Exp Med. 2019 May 23. pii: jem.20182359. doi: 10.1084/jem.20182359. PMID:31123083<ref>PMID:31123083</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6hig" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fenwick, C]]
		+	[[Category: Loredo-Varela, J L]]
		+	[[Category: Pantaleo, G]]
		+	[[Category: Weissenhorn, W]]
		+	[[Category: Anti-pd-1 antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Non-blocking antibody]]
		+	[[Category: Pd-1/pd-l1 pathway]]
		+	[[Category: Tumor clearance]]

OCA: Protected "6hig" [edit=sysop:move=sysop]

2018-09-05T08:48:28Z

Protected "6hig" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 5 September 2018

OCA: New page: '''Unreleased structure''' The entry 6hig is ON HOLD Authors: Description: Category: Unreleased Structures

2018-09-05T08:48:27Z

New page: '''Unreleased structure''' The entry 6hig is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6hig is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]