6hxv - Revision history

OCA at 11:42, 24 January 2024

2024-01-24T11:42:05Z

←Older revision		Revision as of 11:42, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6hxv' size='340' side='right'caption='[[6hxv]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='6hxv' size='340' side='right'caption='[[6hxv]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6hxv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6HXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HXV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6htx\|6htx]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ccdc61, zgc:153153 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=7955 Brachidanio rerio])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [https://pdbe.org/6hxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [https://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [~~http~~://pdbe.org/6hxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CCD61_DANRE CCD61_DANRE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barnabas, D]]	+	[[Category: Barnabas D]]
-	~~[[Category: Breugel, M van~~]]	+	[[Category: Ochi T]]
-	[[Category: Ochi, T]]	+	[[Category: Van Breugel M]]
-	[[Category: ~~Centrosome]]~~	+
-	~~[[Category: Cilia]]~~	+
-	~~[[Category: Proto-filament]]~~	+
-	~~[[Category: Scaffold protein]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 05:56, 20 May 2020

2020-05-20T05:56:43Z

←Older revision		Revision as of 05:56, 20 May 2020
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [http://pdbe.org/6hxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [http://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [http://pdbe.org/6hxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [http://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated structures, such as the striated fibers in Chlamydomonas that are important for ciliary function. The conserved protein CCDC61/VFL3 is involved in this process, but its exact role is unclear. Here, we show that CCDC61 is a paralog of SAS6. Crystal structures of CCDC61 demonstrate that it contains two homodimerization interfaces that are similar to those found in SAS6, but result in the formation of linear filaments rather than rings. Furthermore, we show that CCDC61 binds microtubules and that residues involved in CCDC61 microtubule binding are important for ciliary function in Chlamydomonas. Together, our findings suggest that CCDC61 and SAS6 functionally diverged from a common ancestor while retaining the ability to scaffold the assembly of basal body-associated structures or centrioles, respectively.
		+
		+	CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.,Ochi T, Quarantotti V, Lin H, Jullien J, Rosa E Silva I, Boselli F, Barnabas DD, Johnson CM, McLaughlin SH, Freund SMV, Blackford AN, Kimata Y, Goldstein RE, Jackson SP, Blundell TL, Dutcher SK, Gergely F, van Breugel M Structure. 2020 May 5. pii: S0969-2126(20)30131-3. doi:, 10.1016/j.str.2020.04.010. PMID:32375023<ref>PMID:32375023</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6hxv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:21, 6 May 2020

2020-05-06T06:21:18Z

←Older revision		Revision as of 06:21, 6 May 2020
Line 1:		Line 1:

	==Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 (F129E/D130A)==		==Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 (F129E/D130A)==
-	<StructureSection load='6hxv' size='340' side='right'caption='[[6hxv]]' scene=''>	+	<StructureSection load='6hxv' size='340' side='right'caption='[[6hxv]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6HXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6hxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6HXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [http://pdbe.org/6hxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [http://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6htx\|6htx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ccdc61, zgc:153153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [http://pdbe.org/6hxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [http://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barnabas D]]	+	[[Category: Barnabas, D]]
-	[[Category: Ochi T]]	+	[[Category: Breugel, M van]]
-	[[Category: ~~Van Breugel M~~]]	+	[[Category: Ochi, T]]
		+	[[Category: Centrosome]]
		+	[[Category: Cilia]]
		+	[[Category: Proto-filament]]
		+	[[Category: Scaffold protein]]
		+	[[Category: Structural protein]]

OCA at 06:39, 29 April 2020

2020-04-29T06:39:13Z

←Older revision		Revision as of 06:39, 29 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6hxv is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 (F129E/D130A)==
-		+	<StructureSection load='6hxv' size='340' side='right'caption='[[6hxv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6HXV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6hxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxv OCA], [http://pdbe.org/6hxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxv RCSB], [http://www.ebi.ac.uk/pdbsum/6hxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Barnabas D]]
		+	[[Category: Ochi T]]
		+	[[Category: Van Breugel M]]

OCA at 03:29, 10 October 2019

2019-10-10T03:29:24Z

←Older revision		Revision as of 03:29, 10 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6hxv is ON HOLD	+	The entry 6hxv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:08, 31 October 2018

2018-10-31T05:08:57Z

←Older revision		Revision as of 05:08, 31 October 2018
Line 3:		Line 3:
	The entry 6hxv is ON HOLD		The entry 6hxv is ON HOLD

-	Authors: ~~Barnabas, D., Ochi, T., van Breugel, M.~~	+	Authors:

-	Description: ~~Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 (F129E/D130A)~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Van Breugel, M]]
-	[[Category: Barnabas, D]]
-	[[Category: Ochi, T]]

OCA: Protected "6hxv" [edit=sysop:move=sysop]

2018-10-24T04:16:44Z

Protected "6hxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 24 October 2018

OCA: New page: '''Unreleased structure''' The entry 6hxv is ON HOLD Authors: Barnabas, D., Ochi, T., van Breugel, M. Description: Crystal structure of the head and coiled-coil domains of zebrafish CC...

2018-10-24T04:16:41Z

New page: '''Unreleased structure''' The entry 6hxv is ON HOLD Authors: Barnabas, D., Ochi, T., van Breugel, M. Description: Crystal structure of the head and coiled-coil domains of zebrafish CC...

New page

'''Unreleased structure'''

The entry 6hxv is ON HOLD

Authors: Barnabas, D., Ochi, T., van Breugel, M.

Description: Crystal structure of the head and coiled-coil domains of zebrafish CCDC61 (F129E/D130A)
[[Category: Unreleased Structures]]
[[Category: Van Breugel, M]]
[[Category: Barnabas, D]]
[[Category: Ochi, T]]