6i66 - Revision history

OCA at 11:47, 24 January 2024

2024-01-24T11:47:41Z

←Older revision		Revision as of 11:47, 24 January 2024
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	<StructureSection load='6i66' size='340' side='right'caption='[[6i66]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6i66' size='340' side='right'caption='[[6i66]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i66]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I66 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6I66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I66 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=H4Q:4-~~[~~(2~{R})-butan-2-yl~~]~~phenol'>H4Q</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6i61\|6i61]], [[6i62\|6i62]], [[6i63\|6i63]], [[6i64\|6i64]], [[6i65\|6i65]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4Q:4-[(2~{R})-butan-2-yl]phenol'>H4Q</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:]~~]</b~~></td>~~<td class="sblockDat">ESRRG, ERR3, ERRG2, KIAA0832, NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i66 OCA], [https://pdbe.org/6i66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i66 RCSB], [https://www.ebi.ac.uk/pdbsum/6i66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i66 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i66 OCA], [~~http~~://pdbe.org/6i66 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i66 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i66 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i66 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>	+	[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6i66" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6i66" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Estrogen-related receptor 3D structures\|Estrogen-related receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blanc, P]]	+	[[Category: Blanc P]]
-	[[Category: Bourguet, W]]	+	[[Category: Bourguet W]]
-	[[Category: Delfosse, V]]	+	[[Category: Delfosse V]]
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Transcription factor nuclear receptor endocrine disruptor~~]]	+

OCA at 08:42, 27 November 2019

2019-11-27T08:42:12Z

←Older revision		Revision as of 08:42, 27 November 2019
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	<StructureSection load='6i66' size='340' side='right'caption='[[6i66]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6i66' size='340' side='right'caption='[[6i66]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i66]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I66 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4Q:4-[(2~{R})-butan-2-yl]phenol'>H4Q</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4Q:4-[(2~{R})-butan-2-yl]phenol'>H4Q</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i61\|6i61]], [[6i62\|6i62]], [[6i63\|6i63]], [[6i64\|6i64]], [[6i65\|6i65]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i61\|6i61]], [[6i62\|6i62]], [[6i63\|6i63]], [[6i64\|6i64]], [[6i65\|6i65]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG, ERR3, ERRG2, KIAA0832, NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i66 OCA], [http://pdbe.org/6i66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i66 RCSB], [http://www.ebi.ac.uk/pdbsum/6i66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i66 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i66 OCA], [http://pdbe.org/6i66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i66 RCSB], [http://www.ebi.ac.uk/pdbsum/6i66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i66 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blanc, P]]		[[Category: Blanc, P]]

OCA at 05:49, 3 July 2019

2019-07-03T05:49:01Z

←Older revision		Revision as of 05:49, 3 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6i66 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of human ERRg LBD in complex with 4-sec-butylphenol==
		+	<StructureSection load='6i66' size='340' side='right'caption='[[6i66]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6i66]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I66 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4Q:4-[(2~{R})-butan-2-yl]phenol'>H4Q</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6i61\|6i61]], [[6i62\|6i62]], [[6i63\|6i63]], [[6i64\|6i64]], [[6i65\|6i65]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i66 OCA], [http://pdbe.org/6i66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i66 RCSB], [http://www.ebi.ac.uk/pdbsum/6i66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i66 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The estrogen-related receptor gamma (ERRgamma, NR3B3) is a constitutively active nuclear receptor which has been proposed to act as a mediator of the low-dose effects of a number of environmental endocrine-disrupting chemicals (EDCs) such as the xenoestrogen bisphenol-A (BPA). To better characterize the ability of exogenous compounds to bind and activate ERRgamma, we used a combination of cell-based, biochemical, structural and computational approaches. A purposely created stable cell line allowed for the determination of the EC50s for over 30 environmental ERRgamma ligands, including previously unknown ones. Interestingly, affinity constants (Kds) of the most potent compounds measured by isothermal titration calorimetry were in the 50-500 nM range, in agreement with their receptor activation potencies. Crystallographic analysis of the interaction between the ERRgamma ligand-binding domain (LBD) and compounds of the bisphenol, alkylphenol and naphthol families revealed a partially shared binding mode and minimal alterations of the receptor conformation upon ligand binding. Further biophysical characterizations coupled to molecular dynamics simulations suggested a mechanism through which ERRgamma ligands would exhibit their agonistic properties by preserving the transcriptionally active form of the receptor while rigidifying some loop regions with associated functions. This unique mechanism contrasts with the classical one involving a ligand-induced repositioning and stabilization of the C-terminal activation helix H12.

-	~~Authors: Delfosse~~, V., ~~Blanc~~, P., ~~Bourguet~~, W.	+	Insights into the activation mechanism of human estrogen-related receptor gamma by environmental endocrine disruptors.,Thouennon E, Delfosse V, Bailly R, Blanc P, Boulahtouf A, Grimaldi M, Barducci A, Bourguet W, Balaguer P Cell Mol Life Sci. 2019 May 24. pii: 10.1007/s00018-019-03129-x. doi:, 10.1007/s00018-019-03129-x. PMID:31127318<ref>PMID:31127318</ref>

-	~~Description: Crystal structure~~ of ~~human ERRg LBD in complex with 4~~-~~sec~~-~~butylphenol~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6i66" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Blanc, P]]		[[Category: Blanc, P]]
-	[[Category: Delfosse, V]]
	[[Category: Bourguet, W]]		[[Category: Bourguet, W]]
		+	[[Category: Delfosse, V]]
		+	[[Category: Nuclear protein]]
		+	[[Category: Transcription factor nuclear receptor endocrine disruptor]]

OCA: Protected "6i66" [edit=sysop:move=sysop]

2018-12-02T18:37:58Z

Protected "6i66" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:37, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6i66 is ON HOLD until Paper Publication Authors: Delfosse, V., Blanc, P., Bourguet, W. Description: Crystal structure of human ERRg LBD in complex ...

2018-12-02T18:37:57Z

New page: '''Unreleased structure''' The entry 6i66 is ON HOLD until Paper Publication Authors: Delfosse, V., Blanc, P., Bourguet, W. Description: Crystal structure of human ERRg LBD in complex ...

New page

'''Unreleased structure'''

The entry 6i66 is ON HOLD until Paper Publication

Authors: Delfosse, V., Blanc, P., Bourguet, W.

Description: Crystal structure of human ERRg LBD in complex with 4-sec-butylphenol
[[Category: Unreleased Structures]]
[[Category: Blanc, P]]
[[Category: Delfosse, V]]
[[Category: Bourguet, W]]