6i6u - Revision history

OCA at 11:48, 24 January 2024

2024-01-24T11:48:04Z

←Older revision		Revision as of 11:48, 24 January 2024
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	<StructureSection load='6i6u' size='340' side='right'caption='[[6i6u]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='6i6u' size='340' side='right'caption='[[6i6u]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i6u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6I6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I6U FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~rpsF~~, ~~TTHA0245 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=300852 THET8])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6i6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6u OCA], [~~http~~://pdbe.org/6i6u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6i6u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6i6u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6u OCA], [https://pdbe.org/6i6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i6u RCSB], [https://www.ebi.ac.uk/pdbsum/6i6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8]] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]	+	[https://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Logan~~, D T~~]]	+	[[Category: Logan DT]]
-	[[Category: Oliveberg, M]]	+	[[Category: Oliveberg M]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	~~[[Category: Circular permutant]]~~	+
-	~~[[Category: Cis-proline]]~~	+
-	~~[[Category: Designed protein]]~~	+
-	~~[[Category: Local unfolding]]~~	+
-	~~[[Category: Ribosomal protein]]~~	+
-	~~[[Category: Strand swap~~]]	+

OCA at 06:44, 9 December 2020

2020-12-09T06:44:47Z

←Older revision		Revision as of 06:44, 9 December 2020
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	<StructureSection load='6i6u' size='340' side='right'caption='[[6i6u]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='6i6u' size='340' side='right'caption='[[6i6u]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6i6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6U OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6I6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6i6u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6I6U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6i6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6u OCA], [http://pdbe.org/6i6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i6u RCSB], [http://www.ebi.ac.uk/pdbsum/6i6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6u ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpsF, TTHA0245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6i6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6u OCA], [http://pdbe.org/6i6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i6u RCSB], [http://www.ebi.ac.uk/pdbsum/6i6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8]] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]		[[http://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8]] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although folded proteins are commonly depicted as simplistic combinations of beta-strands and alpha-helices, the actual properties and functions of these secondary-structure elements in their native contexts are just partly understood. The principal reason is that the behavior of individual beta- and alpha-elements is obscured by the global folding cooperativity. In this study, we have circumvented this problem by designing frustrated variants of the mixed alpha/beta-protein S6, which allow the structural behavior of individual beta-strands and alpha-helices to be targeted selectively by stopped-flow kinetics, X-ray crystallography, and solution-state NMR. Essentially, our approach is based on provoking intramolecular "domain swap." The results show that the alpha- and beta-elements have quite different characteristics: The swaps of beta-strands proceed via global unfolding, whereas the alpha-helices are free to swap locally in the native basin. Moreover, the alpha-helices tend to hybridize and to promote protein association by gliding over to neighboring molecules. This difference in structural behavior follows directly from hydrogen-bonding restrictions and suggests that the protein secondary structure defines not only tertiary geometry, but also maintains control in function and structural evolution. Finally, our alternative approach to protein folding and native-state dynamics presents a generally applicable strategy for in silico design of protein models that are computationally testable in the microsecond-millisecond regime.
		+
		+	Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins.,Wang H, Logan DT, Danielsson J, Oliveberg M Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28775-28783. doi:, 10.1073/pnas.1920455117. Epub 2020 Nov 4. PMID:33148805<ref>PMID:33148805</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6i6u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosomal protein S6\|Ribosomal protein S6]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Thet8]]
	[[Category: Logan, D T]]		[[Category: Logan, D T]]
	[[Category: Oliveberg, M]]		[[Category: Oliveberg, M]]

OCA at 06:42, 27 November 2019

2019-11-27T06:42:23Z

←Older revision		Revision as of 06:42, 27 November 2019
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-	'''Unreleased structure'''

-	~~The entry 6i6u is ON HOLD~~	+	==Circular permutant of ribosomal protein S6, adding 9aa to N terminal of P81-82, L75A mutant==
-		+	<StructureSection load='6i6u' size='340' side='right'caption='[[6i6u]], [[Resolution\|resolution]] 1.57Å' scene=''>
-	~~Authors: Wang, H., Logan, D.T., Oliveberg, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6i6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I6U FirstGlance]. <br>
-	~~Description:~~ Circular permutant of ribosomal protein S6, adding 9aa to N terminal of P81-82, L75A mutant	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6u OCA], [http://pdbe.org/6i6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i6u RCSB], [http://www.ebi.ac.uk/pdbsum/6i6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6u ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Logan, D.T]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RS6_THET8 RS6_THET8]] Located on the outer edge of the platform on the body of the 30S subunit.[HAMAP-Rule:MF_00360]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Logan, D T]]
	[[Category: Oliveberg, M]]		[[Category: Oliveberg, M]]
	[[Category: Wang, H]]		[[Category: Wang, H]]
		+	[[Category: Circular permutant]]
		+	[[Category: Cis-proline]]
		+	[[Category: Designed protein]]
		+	[[Category: Local unfolding]]
		+	[[Category: Ribosomal protein]]
		+	[[Category: Strand swap]]

OCA: Protected "6i6u" [edit=sysop:move=sysop]

2018-12-02T18:39:56Z

Protected "6i6u" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:39, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6i6u is ON HOLD Authors: Wang, H., Logan, D.T., Oliveberg, M. Description: Circular permutant of ribosomal protein S6, adding 9aa to N terminal of ...

2018-12-02T18:39:55Z

New page: '''Unreleased structure''' The entry 6i6u is ON HOLD Authors: Wang, H., Logan, D.T., Oliveberg, M. Description: Circular permutant of ribosomal protein S6, adding 9aa to N terminal of ...

New page

'''Unreleased structure'''

The entry 6i6u is ON HOLD

Authors: Wang, H., Logan, D.T., Oliveberg, M.

Description: Circular permutant of ribosomal protein S6, adding 9aa to N terminal of P81-82, L75A mutant
[[Category: Unreleased Structures]]
[[Category: Logan, D.T]]
[[Category: Oliveberg, M]]
[[Category: Wang, H]]