6ibd - Revision history

OCA at 11:50, 24 January 2024

2024-01-24T11:50:54Z

←Older revision		Revision as of 11:50, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6ibd' size='340' side='right'caption='[[6ibd]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='6ibd' size='340' side='right'caption='[[6ibd]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ibd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ibd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IBD FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>INPP5D, SHIP, SHIP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphatidylinositol~~-3,~~4,5-trisphosphate_5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.~~1.~~3.86 3.1.3.86] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ibd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ibd OCA], [https://pdbe.org/6ibd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ibd RCSB], [https://www.ebi.ac.uk/pdbsum/6ibd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ibd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ibd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ibd OCA], [https://pdbe.org/6ibd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ibd RCSB], [https://www.ebi.ac.uk/pdbsum/6ibd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ibd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN]] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>	+	[https://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Bradshaw WJ]]
-	[[Category: Bradshaw~~, W J~~]]	+	[[Category: Burgess-Brown N]]
-	[[Category: Burgess-Brown, N]]	+	[[Category: Edwards A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Fernandez-Cid A]]
-	[[Category: Edwards, A]]	+	[[Category: Gileadi O]]
-	[[Category: Fernandez-Cid, A]]	+	[[Category: Williams EP]]
-	[[Category: Gileadi, O]]	+	[[Category: Von Delft F]]
-	[[Category: Williams~~, E P~~]]	+
-	[[Category: ~~Alzheimer's disease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphatidylinositol phosphate phosphatase~~]]	+

OCA at 11:03, 30 March 2022

2022-03-30T11:03:53Z

←Older revision		Revision as of 11:03, 30 March 2022
Line 1:		Line 1:

	==The Phosphatase and C2 domains of Human SHIP1==		==The Phosphatase and C2 domains of Human SHIP1==
-	<StructureSection load='6ibd' size='340' side='right' caption='[[6ibd]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='6ibd' size='340' side='right'caption='[[6ibd]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ibd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IBD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ibd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IBD FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.86 3.1.3.86] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5D, SHIP, SHIP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ibd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ibd OCA], [~~http~~://pdbe.org/6ibd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ibd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ibd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ibd ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.86 3.1.3.86] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ibd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ibd OCA], [https://pdbe.org/6ibd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ibd RCSB], [https://www.ebi.ac.uk/pdbsum/6ibd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ibd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN]] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>	+	[[https://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN]] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase]]		[[Category: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 12:10, 16 January 2019

2019-01-16T12:10:40Z

←Older revision		Revision as of 12:10, 16 January 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6ibd is ~~ON HOLD~~	+	==The Phosphatase and C2 domains of Human SHIP1==
-		+	<StructureSection load='6ibd' size='340' side='right' caption='[[6ibd]], [[Resolution\|resolution]] 1.48Å' scene=''>
-	~~Authors~~: ~~Bradshaw~~, W.J., ~~Williams~~, E.P., ~~Fernandez-Cid~~, A., ~~Burgess~~-~~Brown~~, N., ~~von Delft~~, F., ~~Arrowsmith~~, C.H., ~~Edwards~~, A., Bountra, C., ~~Gileadi~~, O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ibd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IBD FirstGlance]. <br>
-	~~Description~~: ~~The Phosphatase and C2 domains of Human SHIP1~~	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.86 3.1.3.86] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ibd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ibd OCA], [http://pdbe.org/6ibd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ibd RCSB], [http://www.ebi.ac.uk/pdbsum/6ibd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ibd ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN]] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Bradshaw, W J]]
		+	[[Category: Burgess-Brown, N]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A]]
	[[Category: Fernandez-Cid, A]]		[[Category: Fernandez-Cid, A]]
-	[[Category: Williams, E.P]]
-	[[Category: Arrowsmith, C.H]]
-	[[Category: Burgess-Brown, N]]
	[[Category: Gileadi, O]]		[[Category: Gileadi, O]]
-	[[Category: ~~Bradshaw~~, ~~W.J~~]]	+	[[Category: Williams, E P]]
-	[[Category: ~~Edwards, A~~]]	+	[[Category: Alzheimer's disease]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Hydrolase]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Phosphatidylinositol phosphate phosphatase]]

OCA: Protected "6ibd" [edit=sysop:move=sysop]

2018-12-05T05:05:28Z

Protected "6ibd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6ibd is ON HOLD Authors: Bradshaw, W.J., Williams, E.P., Fernandez-Cid, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra...

2018-12-05T05:05:27Z

New page: '''Unreleased structure''' The entry 6ibd is ON HOLD Authors: Bradshaw, W.J., Williams, E.P., Fernandez-Cid, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra...

New page

'''Unreleased structure'''

The entry 6ibd is ON HOLD

Authors: Bradshaw, W.J., Williams, E.P., Fernandez-Cid, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Description: The Phosphatase and C2 domains of Human SHIP1
[[Category: Unreleased Structures]]
[[Category: Fernandez-Cid, A]]
[[Category: Williams, E.P]]
[[Category: Arrowsmith, C.H]]
[[Category: Burgess-Brown, N]]
[[Category: Gileadi, O]]
[[Category: Bradshaw, W.J]]
[[Category: Edwards, A]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]