6ihd - Revision history

OCA at 09:41, 22 November 2023

2023-11-22T09:41:39Z

←Older revision		Revision as of 09:41, 22 November 2023
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	==Crystal structure of Malate dehydrogenase from Metallosphaera sedula==		==Crystal structure of Malate dehydrogenase from Metallosphaera sedula==
-	<StructureSection load='6ihd' size='340' side='right'caption='[[6ihd]]' scene=''>	+	<StructureSection load='6ihd' size='340' side='right'caption='[[6ihd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IHD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ihd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metallosphaera_sedula Metallosphaera sedula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IHD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ihd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihd OCA], [https://pdbe.org/6ihd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ihd RCSB], [https://www.ebi.ac.uk/pdbsum/6ihd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihd ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETX:2-ETHOXYETHANOL'>ETX</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ihd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihd OCA], [https://pdbe.org/6ihd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ihd RCSB], [https://www.ebi.ac.uk/pdbsum/6ihd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A088E2H7_9CREN A0A088E2H7_9CREN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metallosphaera sedula is a thermoacidophilic autotrophic archaeon and known to utilize the 3-hydroxypropionate/4-hydroxybutyrate cycle (3-HP/4-HB cycle) as a carbon fixation pathway. The 3-HP/4-HB cycle in M. sedula is associated with central metabolism, and malate dehydrogenase (MDH) is an enzyme involved in the central metabolism that converts malate to oxaloacetate. To elucidate the enzymatic properties of MDH from M. sedula (MsMDH), we determined the crystal structure of MsMDH as a complex with NAD(+) and a ternary complex with malate and NAD(+). Based on its complex structures and biochemical experiments, we observed that MsMDH can utilize both NAD(+) and NADP(+) as a cofactor. In addition, we revealed that MsMDH shows a conformational change at the active site upon substrate binding. Based on the comparison with other MDHs, we revealed that MsMDH was distinguished from general MDHs due to a Lys80 residue, and this difference is likely to influence the unique cofactor specificity of MsMDH.
		+
		+	Crystal structure and biochemical characterization of malate dehydrogenase from Metallosphaera sedula.,Lee D, Hong J, Kim KJ Biochem Biophys Res Commun. 2019 Feb 12;509(3):833-838. doi:, 10.1016/j.bbrc.2019.01.018. Epub 2019 Jan 10. PMID:30638660<ref>PMID:30638660</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ihd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Malate Dehydrogenase 3D structures\|Malate Dehydrogenase 3D structures]]		*[[Malate Dehydrogenase 3D structures\|Malate Dehydrogenase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Metallosphaera sedula]]
	[[Category: Kim KJ]]		[[Category: Kim KJ]]
	[[Category: Lee D]]		[[Category: Lee D]]

OCA at 10:28, 18 March 2021

2021-03-18T10:28:13Z

←Older revision		Revision as of 10:28, 18 March 2021
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	<StructureSection load='6ihd' size='340' side='right'caption='[[6ihd]]' scene=''>		<StructureSection load='6ihd' size='340' side='right'caption='[[6ihd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6IHD FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IHD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ihd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihd OCA], [~~http~~://pdbe.org/6ihd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ihd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ihd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihd ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ihd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihd OCA], [https://pdbe.org/6ihd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ihd RCSB], [https://www.ebi.ac.uk/pdbsum/6ihd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:46, 9 September 2020

2020-09-09T09:46:59Z

←Older revision		Revision as of 09:46, 9 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ihd is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Malate dehydrogenase from Metallosphaera sedula==
		+	<StructureSection load='6ihd' size='340' side='right'caption='[[6ihd]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IHD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IHD FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ihd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ihd OCA], [http://pdbe.org/6ihd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ihd RCSB], [http://www.ebi.ac.uk/pdbsum/6ihd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ihd ProSAT]</span></td></tr>
		+	</table>

-	~~Authors: Lee, D., Kim, K.J.~~	+	==See Also==
-		+	*[[Malate Dehydrogenase 3D structures\|Malate Dehydrogenase 3D structures]]
-	~~Description: Crystal strcuture of~~ Malate ~~dehydrogenase from Metallosphaera sedula~~	+	__TOC__
-	[[Category: ~~Unreleased~~ Structures]]	+	</StructureSection>
-	[[Category: ~~Lee, D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kim, K.J~~]]	+	[[Category: Kim KJ]]
		+	[[Category: Lee D]]

OCA at 04:19, 24 October 2018

2018-10-24T04:19:33Z

←Older revision		Revision as of 04:19, 24 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ihd is ON HOLD	+	The entry 6ihd is ON HOLD until Paper Publication

	Authors: Lee, D., Kim, K.J.		Authors: Lee, D., Kim, K.J.

OCA at 06:23, 17 October 2018

2018-10-17T06:23:33Z

←Older revision		Revision as of 06:23, 17 October 2018
Line 3:		Line 3:
	The entry 6ihd is ON HOLD		The entry 6ihd is ON HOLD

-	Authors: Lee, D., Kim, K.-J.	+	Authors: Lee, D., Kim, K.J.

	Description: Crystal strcuture of Malate dehydrogenase from Metallosphaera sedula		Description: Crystal strcuture of Malate dehydrogenase from Metallosphaera sedula
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Kim, K.-J]]
	[[Category: Lee, D]]		[[Category: Lee, D]]
		+	[[Category: Kim, K.J]]

OCA: Protected "6ihd" [edit=sysop:move=sysop]

2018-10-10T06:21:09Z

Protected "6ihd" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:21, 10 October 2018

OCA: New page: '''Unreleased structure''' The entry 6ihd is ON HOLD Authors: Lee, D., Kim, K.-J. Description: Crystal strcuture of Malate dehydrogenase from Metallosphaera sedula [[Category: Unreleas...

2018-10-10T06:21:07Z

New page: '''Unreleased structure''' The entry 6ihd is ON HOLD Authors: Lee, D., Kim, K.-J. Description: Crystal strcuture of Malate dehydrogenase from Metallosphaera sedula [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 6ihd is ON HOLD

Authors: Lee, D., Kim, K.-J.

Description: Crystal strcuture of Malate dehydrogenase from Metallosphaera sedula
[[Category: Unreleased Structures]]
[[Category: Kim, K.-J]]
[[Category: Lee, D]]