6ilj - Revision history

OCA at 01:47, 11 April 2020

2020-04-11T01:47:29Z

←Older revision		Revision as of 01:47, 11 April 2020
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	<SX load='6ilj' size='340' side='right' viewer='molstar' caption='[[6ilj]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6ilj' size='340' side='right' viewer='molstar' caption='[[6ilj]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ilj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ILJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ilj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ILJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD55, CR, DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD55, CR, DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ilj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilj OCA], [http://pdbe.org/6ilj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ilj RCSB], [http://www.ebi.ac.uk/pdbsum/6ilj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ilj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilj OCA], [http://pdbe.org/6ilj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ilj RCSB], [http://www.ebi.ac.uk/pdbsum/6ilj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:09, 6 March 2020

2020-03-06T22:09:01Z

←Older revision		Revision as of 22:09, 6 March 2020
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	==Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 5.5==		==Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 5.5==
-	<~~StructureSection~~ load='6ilj' size='340' side='right'caption='[[6ilj]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<SX load='6ilj' size='340' side='right' viewer='molstar' caption='[[6ilj]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ilj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ILJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ilj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ILJ FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Echovirus e6]]		[[Category: Echovirus e6]]
	[[Category: Human]]		[[Category: Human]]

OCA at 23:04, 5 June 2019

2019-06-05T23:04:01Z

←Older revision		Revision as of 23:04, 5 June 2019
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>		[[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enterovirus B (EV-B), a major proportion of the genus Enterovirus in the family Picornaviridae, is the causative agent of severe human infectious diseases. Although cellular receptors for coxsackievirus B in EV-B have been identified, receptors mediating virus entry, especially the uncoating process of echovirus and other EV-B remain obscure. Here, we found that human neonatal Fc receptor (FcRn) is the uncoating receptor for major EV-B. FcRn binds to the virus particles in the "canyon" through its FCGRT subunit. By obtaining multiple cryo-electron microscopy structures at different stages of virus entry at atomic or near-atomic resolution, we deciphered the underlying mechanisms of enterovirus attachment and uncoating. These structures revealed that different from the attachment receptor CD55, binding of FcRn to the virions induces efficient release of "pocket factor" under acidic conditions and initiates the conformational changes in viral particle, providing a structural basis for understanding the mechanisms of enterovirus entry.
		+
		+	Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.,Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF Cell. 2019 May 30;177(6):1553-1565.e16. doi: 10.1016/j.cell.2019.04.035. Epub, 2019 May 16. PMID:31104841<ref>PMID:31104841</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ilj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:27, 21 May 2019

2019-05-21T07:27:13Z

←Older revision		Revision as of 07:27, 21 May 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ilj is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 5.5==
-		+	<StructureSection load='6ilj' size='340' side='right'caption='[[6ilj]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ilj]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ILJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD55, CR, DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ilj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilj OCA], [http://pdbe.org/6ilj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ilj RCSB], [http://www.ebi.ac.uk/pdbsum/6ilj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Echovirus e6]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Gao, G F]]
		+	[[Category: Liu, S]]
		+	[[Category: Peng, R]]
		+	[[Category: Zhao, X]]
		+	[[Category: Cd55]]
		+	[[Category: Cryo-em]]
		+	[[Category: Echovirus 6]]
		+	[[Category: Virus]]
		+	[[Category: Virus-receptor complex]]

OCA at 04:22, 3 April 2019

2019-04-03T04:22:47Z

←Older revision		Revision as of 04:22, 3 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ilj is ON HOLD	+	The entry 6ilj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:49, 27 March 2019

2019-03-27T04:49:03Z

←Older revision		Revision as of 04:49, 27 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ilj is ON HOLD ~~until Paper Publication~~	+	The entry 6ilj is ON HOLD

	Authors:		Authors:

OCA at 06:24, 19 December 2018

2018-12-19T06:24:45Z

←Older revision		Revision as of 06:24, 19 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ilj is ON HOLD	+	The entry 6ilj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ilj" [edit=sysop:move=sysop]

2018-10-24T04:25:42Z

Protected "6ilj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:25, 24 October 2018

OCA: New page: '''Unreleased structure''' The entry 6ilj is ON HOLD Authors: Description: Category: Unreleased Structures

2018-10-24T04:25:41Z

New page: '''Unreleased structure''' The entry 6ilj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ilj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]