6ioj - Revision history

OCA at 14:33, 29 November 2023

2023-11-29T14:33:18Z

←Older revision		Revision as of 14:33, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [https://pdbe.org/6ioj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [https://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.29Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [https://pdbe.org/6ioj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [https://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:53, 8 February 2023

2023-02-08T06:53:36Z

←Older revision		Revision as of 06:53, 8 February 2023
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	<StructureSection load='6ioj' size='340' side='right'caption='[[6ioj]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='6ioj' size='340' side='right'caption='[[6ioj]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gapA, b1779, JW1768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [https://pdbe.org/6ioj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [https://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [~~http~~://pdbe.org/6ioj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G3P1_ECOLI G3P1_ECOLI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Sun, H]]	+	[[Category: Sun H]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	~~[[Category: Cytosolic protein]]~~	+
-	~~[[Category: Dehydrogenase~~]]	+

OCA at 17:27, 20 November 2019

2019-11-20T17:27:23Z

←Older revision		Revision as of 17:27, 20 November 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [http://pdbe.org/6ioj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [http://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [http://pdbe.org/6ioj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [http://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Silver has long been used as an antibacterial agent, yet its molecular targets remain largely unknown. Using a custom-designed coupling of gel electrophoresis with inductively coupled plasma mass spectrometry (GE-ICP-MS), we identified six silver-binding proteins in E. coli. The majority of the identified proteins are associated with the central carbon metabolism of E. coli. Among them, we unveil that GAPDH, an essential enzyme in glycolysis, serves as a vital target of Ag(+) in E. coli for the first time. We demonstrate that silver inhibits the enzymatic function of GAPDH through targeting Cys149 in its catalytic site. The X-ray structure reveals that Ag(+) coordinates to Cys149 and His176 with a quasi-linear geometry (S-Ag-N angle of 157 degrees ). And unexpectedly, two Ag(+) ions coordinate to Cys288 in the non-catalytic site with weak argentophilic interaction (Ag...Ag distance of 2.9 A). This is the first report on antimicrobial Ag(+) targeting a key enzyme in the glycolytic pathway of E. coli. The findings expand our knowledge on the mode of action and bio-coordination chemistry of silver, particularly silver-targeting residues in proteins at the atomic level.
		+
		+	Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli.,Wang H, Wang M, Yang X, Xu X, Hao Q, Yan A, Hu M, Lobinski R, Li H, Sun H Chem Sci. 2019 Jun 24;10(30):7193-7199. doi: 10.1039/c9sc02032b. eCollection 2019, Aug 14. PMID:31588287<ref>PMID:31588287</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ioj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures\|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]		*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures\|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:21, 14 August 2019

2019-08-14T17:21:52Z

←Older revision		Revision as of 17:21, 14 August 2019
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	<StructureSection load='6ioj' size='340' side='right'caption='[[6ioj]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='6ioj' size='340' side='right'caption='[[6ioj]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gapA, b1779, JW1768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [http://pdbe.org/6ioj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [http://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [http://pdbe.org/6ioj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [http://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures\|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sun, H]]		[[Category: Sun, H]]

OCA at 05:50, 3 July 2019

2019-07-03T05:50:21Z

←Older revision		Revision as of 05:50, 3 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ioj ~~is ON HOLD until Paper Publication~~	+	==Glyceraldehyde-3-phosphate dehydrogenase A (apo-form)==
-		+	<StructureSection load='6ioj' size='340' side='right'caption='[[6ioj]], [[Resolution\|resolution]] 2.29Å' scene=''>
-	~~Authors~~: ~~Wang, H~~.~~, Sun, H~~.~~, Wang, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ioj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IOJ FirstGlance]. <br>
-	~~Description~~: Glyceraldehyde-3-phosphate dehydrogenase A (~~apo-form~~)	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(phosphorylating) Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.12 1.2.1.12] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ioj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioj OCA], [http://pdbe.org/6ioj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ioj RCSB], [http://www.ebi.ac.uk/pdbsum/6ioj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioj ProSAT]</span></td></tr>
-	[[Category: ~~Wang, M~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sun, H]]		[[Category: Sun, H]]
	[[Category: Wang, H]]		[[Category: Wang, H]]
		+	[[Category: Wang, M]]
		+	[[Category: Cytosolic protein]]
		+	[[Category: Dehydrogenase]]

OCA at 05:07, 5 December 2018

2018-12-05T05:07:44Z

←Older revision		Revision as of 05:07, 5 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ioj is ON HOLD	+	The entry 6ioj is ON HOLD until Paper Publication

	Authors: Wang, H., Sun, H., Wang, M.		Authors: Wang, H., Sun, H., Wang, M.

OCA: Protected "6ioj" [edit=sysop:move=sysop]

2018-11-07T10:44:44Z

Protected "6ioj" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:44, 7 November 2018

OCA: New page: '''Unreleased structure''' The entry 6ioj is ON HOLD Authors: Wang, H., Sun, H., Wang, M. Description: Glyceraldehyde-3-phosphate dehydrogenase A (apo-form) [[Category: Unreleased Stru...

2018-11-07T10:44:43Z

New page: '''Unreleased structure''' The entry 6ioj is ON HOLD Authors: Wang, H., Sun, H., Wang, M. Description: Glyceraldehyde-3-phosphate dehydrogenase A (apo-form) [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 6ioj is ON HOLD

Authors: Wang, H., Sun, H., Wang, M.

Description: Glyceraldehyde-3-phosphate dehydrogenase A (apo-form)
[[Category: Unreleased Structures]]
[[Category: Wang, M]]
[[Category: Sun, H]]
[[Category: Wang, H]]