6ipp - Revision history

OCA at 09:49, 22 November 2023

2023-11-22T09:49:04Z

←Older revision		Revision as of 09:49, 22 November 2023
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	<StructureSection load='6ipp' size='340' side='right'caption='[[6ipp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6ipp' size='340' side='right'caption='[[6ipp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ipp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IPP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IPP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ipp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IPP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=FE:FE+(III)+ION'>FE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.699Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ipp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ipp OCA], [~~http~~://pdbe.org/6ipp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ipp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ipp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ipp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ipp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ipp OCA], [https://pdbe.org/6ipp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ipp RCSB], [https://www.ebi.ac.uk/pdbsum/6ipp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ipp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6ipp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ipp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ferroxidase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, H]]	+	[[Category: Chen H]]
-	[[Category: Zang, J]]	+	[[Category: Zang J]]
-	[[Category: Zhao, G]]	+	[[Category: Zhao G]]
-	[[Category: Zhou, K]]	+	[[Category: Zhou K]]
-	~~[[Category: Cysteine]]~~	+
-	~~[[Category: Ferritin]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 12:05, 13 March 2019

2019-03-13T12:05:56Z

←Older revision		Revision as of 12:05, 13 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ipp is ~~ON HOLD until Paper~~ Publication	+	==Non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C==
		+	<StructureSection load='6ipp' size='340' side='right'caption='[[6ipp]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ipp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IPP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ipp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ipp OCA], [http://pdbe.org/6ipp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ipp RCSB], [http://www.ebi.ac.uk/pdbsum/6ipp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ipp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Constructing different protein nanostructures with high-order discrete architectures by using one single building block remains a challenge. Here, we present a simple, effective disulfide-mediated approach to prepare a set of protein nanocages with different geometries from single building block. By genetically deleting an inherent intra-subunit disulfide bond, we can render the conversion of an 8-mer bowl-like protein architecture (NF-8) into a 24-mer ferritin-like nanocage in solution, while selective insertion of an inter-subunit disulfide bond into NF-8 triggers its conversion into a 16-mer lenticular nanocage. Deletion of the same intra-subunit disulfide bond and insertion of the inter-subunit disulfide bond results in the conversion of NF-8 into a 48-mer protein nanocage in solution. Thus, in the laboratory, simple mutation of one protein building block can generate three different protein nanocages in a manner that is highly reminiscent of natural pentamer building block originating from viral capsids that self-assemble into protein assemblies with different symmetries.

-	~~Authors: Zang~~, J., Chen, H., ~~Zhou~~, K., ~~Zhao~~, G.	+	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages.,Zang J, Chen H, Zhang X, Zhang C, Guo J, Du M, Zhao G Nat Commun. 2019 Feb 15;10(1):778. doi: 10.1038/s41467-019-08788-9. PMID:30770832<ref>PMID:30770832</ref>

-	~~Description: Non~~-~~native ferritin 8~~-~~mer mutant-C90A~~/~~C102A~~/~~C130A~~/~~D144C~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Zhou~~, K]]	+	<div class="pdbe-citations 6ipp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ferroxidase]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen, H]]
	[[Category: Zang, J]]		[[Category: Zang, J]]
	[[Category: Zhao, G]]		[[Category: Zhao, G]]
-	[[Category: ~~Chen~~, H]]	+	[[Category: Zhou, K]]
		+	[[Category: Cysteine]]
		+	[[Category: Ferritin]]
		+	[[Category: Oxidoreductase]]

OCA at 06:00, 30 January 2019

2019-01-30T06:00:57Z

←Older revision		Revision as of 06:00, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ipp is ON HOLD	+	The entry 6ipp is ON HOLD until Paper Publication

	Authors: Zang, J., Chen, H., Zhou, K., Zhao, G.		Authors: Zang, J., Chen, H., Zhou, K., Zhao, G.

OCA at 04:47, 2 January 2019

2019-01-02T04:47:34Z

←Older revision		Revision as of 04:47, 2 January 2019
Line 5:		Line 5:
	Authors: Zang, J., Chen, H., Zhou, K., Zhao, G.		Authors: Zang, J., Chen, H., Zhou, K., Zhao, G.

-	Description: ~~non~~-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C	+	Description: Non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhou, K]]		[[Category: Zhou, K]]
	[[Category: Zang, J]]		[[Category: Zang, J]]
-	[[Category: Chen, H]]
	[[Category: Zhao, G]]		[[Category: Zhao, G]]
		+	[[Category: Chen, H]]

OCA: Protected "6ipp" [edit=sysop:move=sysop]

2018-11-14T06:30:30Z

Protected "6ipp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 14 November 2018

OCA: New page: '''Unreleased structure''' The entry 6ipp is ON HOLD Authors: Zang, J., Chen, H., Zhou, K., Zhao, G. Description: non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C [[Category: Un...

2018-11-14T06:30:28Z

New page: '''Unreleased structure''' The entry 6ipp is ON HOLD Authors: Zang, J., Chen, H., Zhou, K., Zhao, G. Description: non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C [[Category: Un...

New page

'''Unreleased structure'''

The entry 6ipp is ON HOLD

Authors: Zang, J., Chen, H., Zhou, K., Zhao, G.

Description: non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C
[[Category: Unreleased Structures]]
[[Category: Zhou, K]]
[[Category: Zang, J]]
[[Category: Chen, H]]
[[Category: Zhao, G]]