6irb - Revision history

OCA at 20:39, 28 October 2020

2020-10-28T20:39:29Z

←Older revision		Revision as of 20:39, 28 October 2020
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	==C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine==		==C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine==
-	<StructureSection load='6irb' size='340' side='right' caption='[[6irb]], [[Resolution\|resolution]] 2.66Å' scene=''>	+	<StructureSection load='6irb' size='340' side='right'caption='[[6irb]], [[Resolution\|resolution]] 2.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6irb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IRB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6irb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IRB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">norpA, PLC-beta, CG3620 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6irb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irb OCA], [http://pdbe.org/6irb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irb RCSB], [http://www.ebi.ac.uk/pdbsum/6irb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6irb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irb OCA], [http://pdbe.org/6irb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irb RCSB], [http://www.ebi.ac.uk/pdbsum/6irb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>		[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cbeta, PLCbeta), a key step for the fast kinetics of the light signaling, is not known. Here, we show that the NORPA C-terminal coiled-coil domain and PDZ-binding motif (CC-PBM) synergistically bind to INAD PDZ45 tandem with an unexpected mode and unprecedented high affinity. Guided by the structure of the INAD-NORPA complex, we discover that INADL is probably a mammalian counterpart of INAD. The INADL PDZ89 tandem specifically binds to PLCbeta4 with a mode that is strikingly similar to that of the INAD-NORPA complex, as revealed by the structure of the INADL PDZ89-PLCbeta4 CC-PBM complex. Therefore, our study suggests that the highly specific PDZ tandem - PLCbeta interactions are an evolutionarily conserved mechanism in PLCbeta signaling in the animal kingdom.
		+
		+	An unexpected INAD PDZ tandem-mediated plcbeta binding in Drosophila photo receptors.,Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M Elife. 2018 Dec 10;7. pii: 41848. doi: 10.7554/eLife.41848. PMID:30526850<ref>PMID:30526850</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6irb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoinositide phospholipase C]]		[[Category: Phosphoinositide phospholipase C]]
	[[Category: Huang, Y]]		[[Category: Huang, Y]]

OCA at 06:12, 2 January 2019

2019-01-02T06:12:22Z

←Older revision		Revision as of 06:12, 2 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6irb is ~~ON HOLD until Paper Publication~~	+	==C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine==
-		+	<StructureSection load='6irb' size='340' side='right' caption='[[6irb]], [[Resolution\|resolution]] 2.66Å' scene=''>
-	~~Authors~~: Ye, F., Li, J., ~~Huang, Y~~., ~~Liu, W~~., ~~Zhang, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6irb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IRB FirstGlance]. <br>
-	~~Description~~: C-~~terminal coiled coil domain~~ of ~~Drosophila~~ phospholipase C ~~beta NORPA, selenomethionine~~	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
-	[[Category: ~~Zhang~~, M]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6irb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irb OCA], [http://pdbe.org/6irb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irb RCSB], [http://www.ebi.ac.uk/pdbsum/6irb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irb ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphoinositide phospholipase C]]
		+	[[Category: Huang, Y]]
		+	[[Category: Li, J]]
	[[Category: Liu, W]]		[[Category: Liu, W]]
	[[Category: Ye, F]]		[[Category: Ye, F]]
-	[[Category: Li, J]]	+	[[Category: Zhang, M]]
-	[[Category: ~~Huang, Y~~]]	+	[[Category: Coiled coil]]
		+	[[Category: Drosophila selenomethionine]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phospholipase c beta]]

OCA at 06:35, 26 December 2018

2018-12-26T06:35:48Z

←Older revision		Revision as of 06:35, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6irb is ON HOLD	+	The entry 6irb is ON HOLD until Paper Publication

-	Authors: Ye, F., Li, J., Liu, Z., Zhang, M.	+	Authors: Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.

	Description: C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine		Description: C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Li, J]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
-	[[Category: Liu, Z]]	+	[[Category: Liu, W]]
	[[Category: Ye, F]]		[[Category: Ye, F]]
		+	[[Category: Li, J]]
		+	[[Category: Huang, Y]]

OCA: Protected "6irb" [edit=sysop:move=sysop]

2018-12-02T18:52:59Z

Protected "6irb" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:52, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6irb is ON HOLD Authors: Ye, F., Li, J., Liu, Z., Zhang, M. Description: C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, se...

2018-12-02T18:52:58Z

New page: '''Unreleased structure''' The entry 6irb is ON HOLD Authors: Ye, F., Li, J., Liu, Z., Zhang, M. Description: C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, se...

New page

'''Unreleased structure'''

The entry 6irb is ON HOLD

Authors: Ye, F., Li, J., Liu, Z., Zhang, M.

Description: C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine
[[Category: Unreleased Structures]]
[[Category: Li, J]]
[[Category: Zhang, M]]
[[Category: Liu, Z]]
[[Category: Ye, F]]