6ivw - Revision history

OCA at 19:26, 29 May 2024

2024-05-29T19:26:51Z

←Older revision		Revision as of 19:26, 29 May 2024
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	<StructureSection load='6ivw' size='340' side='right'caption='[[6ivw]], [[Resolution\|resolution]] 3.72Å' scene=''>		<StructureSection load='6ivw' size='340' side='right'caption='[[6ivw]], [[Resolution\|resolution]] 3.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ivw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae_is53~~ Klebsiella pneumoniae ~~is53~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ivw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_IS53 Klebsiella pneumoniae IS53]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.72Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4wd8\|4wd8]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivw OCA], [https://pdbe.org/6ivw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivw RCSB], [https://www.ebi.ac.uk/pdbsum/6ivw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivw OCA], [https://pdbe.org/6ivw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivw RCSB], [https://www.ebi.ac.uk/pdbsum/6ivw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivw ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 6ivw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ivw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bestrophin 3D structures\|Bestrophin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Klebsiella pneumoniae ~~is53~~]]	+	[[Category: Klebsiella pneumoniae IS53]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, S]]	+	[[Category: Chen S]]
-	[[Category: Kittredge, A]]	+	[[Category: Kittredge A]]
-	[[Category: Yang, T]]	+	[[Category: Yang T]]
-	~~[[Category: Bestrophin-1]]~~	+
-	~~[[Category: Homolog]]~~	+
-	~~[[Category: Klebsiella pneumoniae]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Mutation~~]]	+

OCA at 05:33, 8 June 2022

2022-06-08T05:33:04Z

←Older revision		Revision as of 05:33, 8 June 2022
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	<StructureSection load='6ivw' size='340' side='right'caption='[[6ivw]], [[Resolution\|resolution]] 3.72Å' scene=''>		<StructureSection load='6ivw' size='340' side='right'caption='[[6ivw]], [[Resolution\|resolution]] 3.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ivw]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ivw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_is53 Klebsiella pneumoniae is53]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd8\|4wd8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4wd8\|4wd8]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ivw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivw OCA], [~~http~~://pdbe.org/6ivw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ivw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ivw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivw OCA], [https://pdbe.org/6ivw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivw RCSB], [https://www.ebi.ac.uk/pdbsum/6ivw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Klebsiella pneumoniae is53]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, S]]		[[Category: Chen, S]]
		+	[[Category: Kittredge, A]]
		+	[[Category: Yang, T]]
	[[Category: Bestrophin-1]]		[[Category: Bestrophin-1]]
	[[Category: Homolog]]		[[Category: Homolog]]

OCA at 10:58, 13 November 2019

2019-11-13T10:58:42Z

←Older revision		Revision as of 10:58, 13 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ivw is ~~ON HOLD until Dec 04 2020~~	+	==Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation D269A==
		+	<StructureSection load='6ivw' size='340' side='right'caption='[[6ivw]], [[Resolution\|resolution]] 3.72Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ivw]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd8\|4wd8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivw OCA], [http://pdbe.org/6ivw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivw RCSB], [http://www.ebi.ac.uk/pdbsum/6ivw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations of human BEST1, encoding a Ca(2+)-activated Cl(-) channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the "neck" and "aperture", respectively) in the ion conducting pathway, suggesting a unique dual-switch gating mechanism, which, however, has not been characterized well. Using patch clamp and crystallography, we demonstrate that both the neck and aperture in hBest1 are Ca(2+)-dependent gates essential for preventing channel leakage resulting from Ca(2+)-independent, spontaneous gate opening. Importantly, three patient-derived mutations (D203A, I205T and Y236C) lead to Ca(2+)-independent leakage and elevated Ca(2+)-dependent anion currents due to enhanced opening of the gates. Moreover, we identify a network of residues critically involved in gate operation. Together, our results suggest an indispensable role of the neck and aperture of hBest1 for channel gating, and uncover disease-causing mechanisms of hBest1 gain-of-function mutations.

-	~~Authors: Chen~~, S.	+	Dual Ca(2+)-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.,Ji C, Kittredge A, Hopiavuori A, Ward N, Chen S, Fukuda Y, Zhang Y, Yang T Commun Biol. 2019 Jun 24;2:240. doi: 10.1038/s42003-019-0433-3. eCollection 2019. PMID:31263784<ref>PMID:31263784</ref>

-	~~Description: Crystal structure of~~ a ~~bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation D269A~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ivw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, S]]		[[Category: Chen, S]]
		+	[[Category: Bestrophin-1]]
		+	[[Category: Homolog]]
		+	[[Category: Klebsiella pneumoniae]]
		+	[[Category: Membrane protein]]
		+	[[Category: Mutation]]

OCA at 05:22, 6 March 2019

2019-03-06T05:22:13Z

←Older revision		Revision as of 05:22, 6 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ivw is ON HOLD	+	The entry 6ivw is ON HOLD until Dec 04 2020

	Authors: Chen, S.		Authors: Chen, S.

OCA: Protected "6ivw" [edit=sysop:move=sysop]

2018-12-12T05:13:36Z

Protected "6ivw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 12 December 2018

OCA: New page: '''Unreleased structure''' The entry 6ivw is ON HOLD Authors: Chen, S. Description: Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation D269A...

2018-12-12T05:13:35Z

New page: '''Unreleased structure''' The entry 6ivw is ON HOLD Authors: Chen, S. Description: Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation D269A...

New page

'''Unreleased structure'''

The entry 6ivw is ON HOLD

Authors: Chen, S.

Description: Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation D269A
[[Category: Unreleased Structures]]
[[Category: Chen, S]]