6ixp - Revision history

OCA at 09:54, 22 November 2023

2023-11-22T09:54:51Z

←Older revision		Revision as of 09:54, 22 November 2023
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	<StructureSection load='6ixp' size='340' side='right'caption='[[6ixp]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='6ixp' size='340' side='right'caption='[[6ixp]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ixp]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ixp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IXP FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MYO2~~, ~~CDC66, YOR326W, O6167 (~~[~~http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast~~]~~), MMR1, YLR190W ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=559292 Baker's yeast])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.733Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ixp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixp OCA], [~~http~~://pdbe.org/6ixp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ixp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ixp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ixp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixp OCA], [https://pdbe.org/6ixp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ixp RCSB], [https://www.ebi.ac.uk/pdbsum/6ixp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST]] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref> ~~[[http://www.uniprot.org/uniprot/MMR1_YEAST MMR1_YEAST]] Involved in the guiding of mitochondrial tubules to the bud tip during cell division.<ref>PMID:15201867</ref>~~	+	[https://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6ixp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ixp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tang, K~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Wei, Z~~]]	+	[[Category: Tang K]]
-	[[Category: ~~Cargo binding domain]]~~	+	[[Category: Wei Z]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein binding-cell cycle complex~~]]	+

OCA at 08:36, 24 July 2019

2019-07-24T08:36:38Z

←Older revision		Revision as of 08:36, 24 July 2019
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	==Structure of Myo2-GTD in complex with Mmr1==		==Structure of Myo2-GTD in complex with Mmr1==
-	<StructureSection load='6ixp' size='340' side='right' caption='[[6ixp]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='6ixp' size='340' side='right'caption='[[6ixp]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ixp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ixp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IXP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ixp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixp OCA], [http://pdbe.org/6ixp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ixp RCSB], [http://www.ebi.ac.uk/pdbsum/6ixp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixp ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYO2, CDC66, YOR326W, O6167 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), MMR1, YLR190W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ixp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixp OCA], [http://pdbe.org/6ixp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ixp RCSB], [http://www.ebi.ac.uk/pdbsum/6ixp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST]] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref> [[http://www.uniprot.org/uniprot/MMR1_YEAST MMR1_YEAST]] Involved in the guiding of mitochondrial tubules to the bud tip during cell division.<ref>PMID:15201867</ref>		[[http://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST]] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref> [[http://www.uniprot.org/uniprot/MMR1_YEAST MMR1_YEAST]] Involved in the guiding of mitochondrial tubules to the bud tip during cell division.<ref>PMID:15201867</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Class V myosins are actin-dependent motors, which recognize numerous cellular cargos mainly via the C-terminal globular tail domain (GTD). Myo2, a yeast class V myosin, can transport a broad range of organelles. However, little is known about the capacity of Myo2-GTD to recognize such a diverse array of cargos specifically at the molecular level. Here, we solved crystal structures of Myo2-GTD (at 1.9-3.1 A resolutions) in complex with three cargo adaptor proteins: Smy1 (for polarization of secretory vesicles), Inp2 (for peroxisome transport), and Mmr1 (for mitochondria transport). The structures of Smy1- and Inp2-bound Myo2-GTD, along with site-directed mutagenesis experiments, revealed a binding site in subdomain-I having a hydrophobic groove with high flexibility enabling Myo2-GTD to accommodate different protein sequences. The Myo2-GTD-Mmr1 complex structure confirmed and complemented a previously identified mitochondrion/vacuole-specific binding region. Moreover, differences between the conformations and locations of cargo-binding sites identified here for Myo2 and those reported for mammalian MyoVA (MyoVA) suggest that class V myosins potentially have co-evolved with their specific cargos. Our structural and biochemical analysis not only uncovers a molecular mechanism that explains the diverse cargo recognition by Myo2-GTD, but also provides structural information useful for future functional studies of class V myosins in cargo transport.
		+
		+	Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2.,Tang K, Li Y, Yu C, Wei Z J Biol Chem. 2019 Apr 12;294(15):5896-5906. doi: 10.1074/jbc.RA119.007550. Epub, 2019 Feb 25. PMID:30804213<ref>PMID:30804213</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ixp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Tang, K]]		[[Category: Tang, K]]
	[[Category: Wei, Z]]		[[Category: Wei, Z]]

OCA at 07:31, 6 March 2019

2019-03-06T07:31:31Z

←Older revision		Revision as of 07:31, 6 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ixp is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Structure of Myo2-GTD in complex with Mmr1==
-		+	<StructureSection load='6ixp' size='340' side='right' caption='[[6ixp]], [[Resolution\|resolution]] 2.73Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ixp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IXP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ixp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixp OCA], [http://pdbe.org/6ixp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ixp RCSB], [http://www.ebi.ac.uk/pdbsum/6ixp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST]] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref> [[http://www.uniprot.org/uniprot/MMR1_YEAST MMR1_YEAST]] Involved in the guiding of mitochondrial tubules to the bud tip during cell division.<ref>PMID:15201867</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Tang, K]]
		+	[[Category: Wei, Z]]
		+	[[Category: Cargo binding domain]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein binding-cell cycle complex]]

OCA at 04:49, 2 January 2019

2019-01-02T04:49:14Z

←Older revision		Revision as of 04:49, 2 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ixp is ON HOLD	+	The entry 6ixp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ixp" [edit=sysop:move=sysop]

2018-12-19T06:29:16Z

Protected "6ixp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:29, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6ixp is ON HOLD Authors: Description: Category: Unreleased Structures

2018-12-19T06:29:15Z

New page: '''Unreleased structure''' The entry 6ixp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ixp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]