6iyn - Revision history

OCA at 10:52, 14 June 2023

2023-06-14T10:52:15Z

←Older revision		Revision as of 10:52, 14 June 2023
Line 1:		Line 1:

	==Solution structure of camelid nanobody Nb26 against aflatoxin B1==		==Solution structure of camelid nanobody Nb26 against aflatoxin B1==
-	<StructureSection load='6iyn' size='340' side='right'caption='[[6iyn~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6iyn' size='340' side='right'caption='[[6iyn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6iyn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Alpaca Alpaca~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6iyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IYN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6iyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iyn OCA], [~~http~~://pdbe.org/6iyn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6iyn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6iyn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6iyn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iyn OCA], [https://pdbe.org/6iyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iyn RCSB], [https://www.ebi.ac.uk/pdbsum/6iyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iyn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 6iyn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6iyn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alpaca]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: He, T]]	+	[[Category: Vicugna pacos]]
-	[[Category: Hu, R]]	+	[[Category: He T]]
-	[[Category: Li~~, S L~~]]	+	[[Category: Hu R]]
-	[[Category: Nie, Y]]	+	[[Category: Li SL]]
-	[[Category: Yang~~, Y H~~]]	+	[[Category: Nie Y]]
-	[[Category: Zhu, J]]	+	[[Category: Yang YH]]
-	~~[[Category: Aflatoxin b1]]~~	+	[[Category: Zhu J]]
-	~~[[Category: Aflatoxin b1-binding protein]]~~	+
-	~~[[Category: Camelid antibody]]~~	+
-	~~[[Category: Nanobody~~]]	+

OCA at 07:52, 10 April 2019

2019-04-10T07:52:57Z

←Older revision		Revision as of 07:52, 10 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6iyn is ~~ON HOLD until Feb 14 2020~~	+	==Solution structure of camelid nanobody Nb26 against aflatoxin B1==
		+	<StructureSection load='6iyn' size='340' side='right'caption='[[6iyn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6iyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alpaca Alpaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IYN FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iyn OCA], [http://pdbe.org/6iyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iyn RCSB], [http://www.ebi.ac.uk/pdbsum/6iyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iyn ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nanobodies (Nbs) are the variable domain of the heavy-chain antibodies produced from Camelidae, which possess comparable binding affinities and specificity to conventional antibodies. Nbs have become valuable and versatile tools for numerous biotechnology applications due to their small size (12-15 kDa), high solubility, exceptional stability, and facile genetic manipulation. The interactions between Nbs and protein antigens have been well-studied, but less work has been done to characterize their ability to bind small molecule haptens. Here we present the backbone and side-chain assignments of the (1)H, (13)C and (15)N resonances of Nb26 (123 amino acids), a nanobody that recognizes the hapten aflatoxin B1 (AFB1). These assignments are preliminary work towards the determination of the structure of free Nb26 using NMR spectroscopy, which will provide useful information about the complex structure of "Nb26-AFB1" and the recognition mechanism about how Nb26 binds to AFB1.

-	~~Authors: Nie~~, Y., ~~He, T.~~, Zhu, J., Li, ~~S.L.~~, ~~Hu, R.~~, Yang, Y.H.	+	Chemical shift assignments of a camelid nanobody against aflatoxin B1.,Nie Y, Li S, Zhu J, Hu R, Liu M, He T, Yang Y Biomol NMR Assign. 2019 Apr;13(1):75-78. doi: 10.1007/s12104-018-9855-y. Epub, 2018 Oct 16. PMID:30328057<ref>PMID:30328057</ref>

-	~~Description: Solution structure~~ of ~~camelid nanobody Nb26 against aflatoxin B1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6iyn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alpaca]]
		+	[[Category: Large Structures]]
		+	[[Category: He, T]]
	[[Category: Hu, R]]		[[Category: Hu, R]]
-	[[Category: Li, S.L]]	+	[[Category: Li, S L]]
	[[Category: Nie, Y]]		[[Category: Nie, Y]]
-	[[Category: Yang, Y.H]]	+	[[Category: Yang, Y H]]
	[[Category: Zhu, J]]		[[Category: Zhu, J]]
-	[[Category: ~~He, T~~]]	+	[[Category: Aflatoxin b1]]
		+	[[Category: Aflatoxin b1-binding protein]]
		+	[[Category: Camelid antibody]]
		+	[[Category: Nanobody]]

OCA at 10:22, 16 January 2019

2019-01-16T10:22:33Z

←Older revision		Revision as of 10:22, 16 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6iyn is ON HOLD	+	The entry 6iyn is ON HOLD until Feb 14 2020

	Authors: Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H.		Authors: Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H.

-	Description: Solution structure of camelid Nb26 against aflatoxin B1	+	Description: Solution structure of camelid nanobody Nb26 against aflatoxin B1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Hu, R]]
	[[Category: Li, S.L]]		[[Category: Li, S.L]]
		+	[[Category: Nie, Y]]
	[[Category: Yang, Y.H]]		[[Category: Yang, Y.H]]
	[[Category: Zhu, J]]		[[Category: Zhu, J]]
	[[Category: He, T]]		[[Category: He, T]]
-	[[Category: Hu, R]]
-	[[Category: Nie, Y]]

OCA: Protected "6iyn" [edit=sysop:move=sysop]

2018-12-26T06:38:37Z

Protected "6iyn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 26 December 2018

OCA: New page: '''Unreleased structure''' The entry 6iyn is ON HOLD Authors: Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. Description: Solution structure of camelid Nb26 against aflatoxin B...

2018-12-26T06:38:36Z

New page: '''Unreleased structure''' The entry 6iyn is ON HOLD Authors: Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. Description: Solution structure of camelid Nb26 against aflatoxin B...

New page

'''Unreleased structure'''

The entry 6iyn is ON HOLD

Authors: Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H.

Description: Solution structure of camelid Nb26 against aflatoxin B1
[[Category: Unreleased Structures]]
[[Category: Li, S.L]]
[[Category: Yang, Y.H]]
[[Category: Zhu, J]]
[[Category: He, T]]
[[Category: Hu, R]]
[[Category: Nie, Y]]