6j06 - Revision history

OCA at 09:56, 22 November 2023

2023-11-22T09:56:47Z

←Older revision		Revision as of 09:56, 22 November 2023
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	<StructureSection load='6j06' size='340' side='right'caption='[[6j06]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6j06' size='340' side='right'caption='[[6j06]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j06]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J06 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6J06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j06]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J06 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=99C:(2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl+trihydrogen+diphosphate'>99C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BTN3A1, BTF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=99C:(2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl+trihydrogen+diphosphate'>99C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6j06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j06 OCA], [~~http~~://pdbe.org/6j06 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6j06 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6j06 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6j06 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j06 OCA], [https://pdbe.org/6j06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j06 RCSB], [https://www.ebi.ac.uk/pdbsum/6j06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j06 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN]] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>	+	[https://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai~~, N N~~]]	+	[[Category: Cai NN]]
-	[[Category: Chen~~, C C~~]]	+	[[Category: Chen CC]]
-	[[Category: Guo~~, R T~~]]	+	[[Category: Guo RT]]
-	[[Category: Liu~~, W D~~]]	+	[[Category: Liu WD]]
-	[[Category: Yang~~, Y Y~~]]	+	[[Category: Yang YY]]
-	[[Category: Zhang~~, Y H]]~~	+	[[Category: Zhang YH]]
-	~~[[Category: Butyrophilin]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:52, 10 April 2019

2019-04-10T07:52:59Z

←Older revision		Revision as of 07:52, 10 April 2019
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	<StructureSection load='6j06' size='340' side='right'caption='[[6j06]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6j06' size='340' side='right'caption='[[6j06]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j06]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j06]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J06 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=99C:(2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl+trihydrogen+diphosphate'>99C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=99C:(2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl+trihydrogen+diphosphate'>99C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BTN3A1, BTF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j06 OCA], [http://pdbe.org/6j06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j06 RCSB], [http://www.ebi.ac.uk/pdbsum/6j06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j06 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j06 OCA], [http://pdbe.org/6j06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j06 RCSB], [http://www.ebi.ac.uk/pdbsum/6j06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j06 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN]] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>		[[http://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN]] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human Vgamma9Vdelta2 T cells respond to microbial infections and malignancy by sensing diphosphate-containing metabolites called phosphoantigens, which bind to the intracellular domain of butyrophilin 3A1, triggering extracellular interactions with the Vgamma9Vdelta2 T cell receptor (TCR). Here, we examined the molecular basis of this "inside-out" triggering mechanism. Crystal structures of intracellular butyrophilin 3A proteins alone or in complex with the potent microbial phosphoantigen HMBPP or a synthetic analog revealed key features of phosphoantigens and butyrophilins required for gammadelta T cell activation. Analyses with chemical probes and molecular dynamic simulations demonstrated that dimerized intracellular proteins cooperate in sensing HMBPP to enhance the efficiency of gammadelta T cell activation. HMBPP binding to butyrophilin doubled the binding force between a gammadelta T cell and a target cell during "outside" signaling, as measured by single-cell force microscopy. Our findings provide insight into the "inside-out" triggering of Vgamma9Vdelta2 T cell activation by phosphoantigen-bound butyrophilin, facilitating immunotherapeutic drug design.
		+
		+	A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vgamma9Vdelta2 T Cell Activation.,Yang Y, Li L, Yuan L, Zhou X, Duan J, Xiao H, Cai N, Han S, Ma X, Liu W, Chen CC, Wang L, Li X, Chen J, Kang N, Chen J, Shen Z, Malwal SR, Liu W, Shi Y, Oldfield E, Guo RT, Zhang Y Immunity. 2019 Mar 14. pii: S1074-7613(19)30083-4. doi:, 10.1016/j.immuni.2019.02.016. PMID:30902636<ref>PMID:30902636</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6j06" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cai, N N]]		[[Category: Cai, N N]]

OCA at 07:03, 3 April 2019

2019-04-03T07:03:51Z

←Older revision		Revision as of 07:03, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6j06 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with HMBPP-08==
-		+	<StructureSection load='6j06' size='340' side='right'caption='[[6j06]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~Authors~~: ~~Yang, Y~~.Y., ~~Liu~~, W.D., ~~Cai, N~~.N., ~~Chen~~, C.C., ~~Guo, R~~.T., ~~Zhang, Y~~.H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6j06]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J06 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~intracellular B30~~.~~2 domain~~ of ~~BTN3A1 in complex with THZ~~-~~526~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=99C:(2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl+trihydrogen+diphosphate'>99C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j06 OCA], [http://pdbe.org/6j06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j06 RCSB], [http://www.ebi.ac.uk/pdbsum/6j06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j06 ProSAT]</span></td></tr>
-	[[Category: Chen, C.C]]	+	</table>
-	[[Category: Liu, W.D]]	+	== Function ==
-	[[Category: ~~Zhang~~, Y.H]]	+	[[http://www.uniprot.org/uniprot/BT3A1_HUMAN BT3A1_HUMAN]] Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<ref>PMID:21113407</ref> <ref>PMID:21918970</ref> <ref>PMID:22767497</ref> <ref>PMID:22846996</ref>
-	[[Category: ~~Guo~~, ~~R.T~~]]	+	== References ==
-	[[Category: ~~Cai, N.N~~]]	+	<references/>
-	[[Category: ~~Yang, Y.Y~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cai, N N]]
		+	[[Category: Chen, C C]]
		+	[[Category: Guo, R T]]
		+	[[Category: Liu, W D]]
		+	[[Category: Yang, Y Y]]
		+	[[Category: Zhang, Y H]]
		+	[[Category: Butyrophilin]]
		+	[[Category: Signaling protein]]

OCA at 06:03, 30 January 2019

2019-01-30T06:03:41Z

←Older revision		Revision as of 06:03, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j06 is ON HOLD	+	The entry 6j06 is ON HOLD until Paper Publication

	Authors: Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.		Authors: Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
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	Description: Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with THZ-526		Description: Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with THZ-526
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Liu, W.D]]
	[[Category: Chen, C.C]]		[[Category: Chen, C.C]]
		+	[[Category: Liu, W.D]]
	[[Category: Zhang, Y.H]]		[[Category: Zhang, Y.H]]
	[[Category: Guo, R.T]]		[[Category: Guo, R.T]]
	[[Category: Cai, N.N]]		[[Category: Cai, N.N]]
	[[Category: Yang, Y.Y]]		[[Category: Yang, Y.Y]]

OCA: Protected "6j06" [edit=sysop:move=sysop]

2018-12-26T06:43:12Z

Protected "6j06" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 26 December 2018

OCA: New page: '''Unreleased structure''' The entry 6j06 is ON HOLD Authors: Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H. Description: Crystal structure of intracellular B30.2...

2018-12-26T06:43:11Z

New page: '''Unreleased structure''' The entry 6j06 is ON HOLD Authors: Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H. Description: Crystal structure of intracellular B30.2...

New page

'''Unreleased structure'''

The entry 6j06 is ON HOLD

Authors: Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.

Description: Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with THZ-526
[[Category: Unreleased Structures]]
[[Category: Liu, W.D]]
[[Category: Chen, C.C]]
[[Category: Zhang, Y.H]]
[[Category: Guo, R.T]]
[[Category: Cai, N.N]]
[[Category: Yang, Y.Y]]