6j5x - Revision history

OCA at 10:26, 15 November 2023

2023-11-15T10:26:56Z

←Older revision		Revision as of 10:26, 15 November 2023
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	<StructureSection load='6j5x' size='340' side='right'caption='[[6j5x]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='6j5x' size='340' side='right'caption='[[6j5x]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J5X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6J5X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J5X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6j5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j5x OCA], [~~http~~://pdbe.org/6j5x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6j5x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6j5x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6j5x ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j5x OCA], [https://pdbe.org/6j5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j5x RCSB], [https://www.ebi.ac.uk/pdbsum/6j5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j5x ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8NLC0_CORGL Q8NLC0_CORGL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Corynebacterium glutamicum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hong, H]]	+	[[Category: Hong H]]
-	[[Category: Kim, K J]]	+	[[Category: Kim K-J]]
-	[[Category: Park, W]]	+	[[Category: Park W]]
-	[[Category: Seo, H]]	+	[[Category: Seo H]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:40, 18 December 2019

2019-12-18T07:40:30Z

←Older revision		Revision as of 07:40, 18 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6j5x is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum in complex with Mn2+ and pyruvate==
		+	<StructureSection load='6j5x' size='340' side='right'caption='[[6j5x]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6j5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J5X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j5x OCA], [http://pdbe.org/6j5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j5x RCSB], [http://www.ebi.ac.uk/pdbsum/6j5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j5x ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fumarylacetoacetate hydrolase (FAH) superfamily proteins are found ubiquitously in microbial pathways involved in the catabolism of aromatic substances. Although extensive bioinformatic data on these proteins have been acquired, confusion caused by problems with the annotation of these proteins hinders research into determining their physiological functions. Here we classify 606 FAH superfamily proteins using a maximum likelihood (ML) phylogenetic tree, comparative gene-neighbourhood patterns and in vitro enzyme assays. The FAH superfamily proteins used for the analyses are divided into five distinct subfamilies, and two of them, FPH-A and FPH-B, contain the majority of the proteins of undefined function. These subfamilies include clusters designated FPH-I and FPH-II, respectively, which include two distinct types of fumarylpyruvate hydrolase (FPH), an enzyme involved in the final step of the gentisate pathway. We determined the crystal structures of these FPH enzymes at 2.0 A resolutions and investigate the substrate binding mode by which these types of enzymes can accommodate fumarylpyruvate as a substrate. Consequentially, we identify the molecular signatures of the two types of FPH enzymes among the broadly conserved FAH superfamily proteins. Our studies allowed us to predict the relationship of unknown FAH superfamily proteins using their sequence information.

-	~~Authors: Hong~~, H., ~~Seo~~, H., ~~Kim~~, K.-J.~~, Park, W~~.	+	Sequence, structure and function-based classification of the broadly conserved FAH superfamily reveals two distinct fumarylpyruvate hydrolase subfamilies.,Hong H, Seo H, Park W, Kim KJ Environ Microbiol. 2019 Oct 27. doi: 10.1111/1462-2920.14844. PMID:31657110<ref>PMID:31657110</ref>

-	~~Description: Crystal structure~~ of ~~fumarylpyruvate hydrolase from Corynebacterium glutamicum in complex with Mn2+ and pyruvate~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6j5x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hong, H]]
		+	[[Category: Kim, K J]]
	[[Category: Park, W]]		[[Category: Park, W]]
-	[[Category: Kim, K.-J]]
	[[Category: Seo, H]]		[[Category: Seo, H]]
-	[[Category: ~~Hong, H~~]]	+	[[Category: Hydrolase]]

OCA at 07:12, 13 February 2019

2019-02-13T07:12:27Z

←Older revision		Revision as of 07:12, 13 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j5x is ON HOLD	+	The entry 6j5x is ON HOLD until Paper Publication

-	Authors: Hong, H., Seo, H., Kim, K.-J.	+	Authors: Hong, H., Seo, H., Kim, K.-J., Park, W.

	Description: Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum in complex with Mn2+ and pyruvate		Description: Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum in complex with Mn2+ and pyruvate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Park, W]]
	[[Category: Kim, K.-J]]		[[Category: Kim, K.-J]]
	[[Category: Seo, H]]		[[Category: Seo, H]]
	[[Category: Hong, H]]		[[Category: Hong, H]]

OCA: Protected "6j5x" [edit=sysop:move=sysop]

2019-01-30T06:07:31Z

Protected "6j5x" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:07, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6j5x is ON HOLD Authors: Hong, H., Seo, H., Kim, K.-J. Description: Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum ...

2019-01-30T06:07:30Z

New page: '''Unreleased structure''' The entry 6j5x is ON HOLD Authors: Hong, H., Seo, H., Kim, K.-J. Description: Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum ...

New page

'''Unreleased structure'''

The entry 6j5x is ON HOLD

Authors: Hong, H., Seo, H., Kim, K.-J.

Description: Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum in complex with Mn2+ and pyruvate
[[Category: Unreleased Structures]]
[[Category: Kim, K.-J]]
[[Category: Seo, H]]
[[Category: Hong, H]]