6j7s - Revision history

OCA at 10:03, 22 November 2023

2023-11-22T10:03:05Z

←Older revision		Revision as of 10:03, 22 November 2023
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	<StructureSection load='6j7s' size='340' side='right'caption='[[6j7s]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6j7s' size='340' side='right'caption='[[6j7s]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6j7s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6J7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J7S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.102Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6j7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7s OCA], [~~http~~://pdbe.org/6j7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6j7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6j7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7s OCA], [https://pdbe.org/6j7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j7s RCSB], [https://www.ebi.ac.uk/pdbsum/6j7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P96356_MYCTU P96356_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cui, S]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Gao, X]]	+	[[Category: Cui S]]
-	[[Category: Wang, M]]	+	[[Category: Gao X]]
-	[[Category: Wojdyla~~, J A~~]]	+	[[Category: Wang M]]
-	[[Category: Yu, X]]	+	[[Category: Wojdyla JA]]
-	[[Category: Zhu, K]]	+	[[Category: Yu X]]
-	~~[[Category: Guanylyltransferase]]~~	+	[[Category: Zhu K]]
-	~~[[Category: Guanylyltransferase-like toxin]]~~	+
-	~~[[Category: Ta]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 05:57, 20 May 2020

2020-05-20T05:57:24Z

←Older revision		Revision as of 05:57, 20 May 2020
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	==Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis==		==Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis==
-	<StructureSection load='6j7s' size='340' side='right'caption='[[6j7s]]' scene=''>	+	<StructureSection load='6j7s' size='340' side='right'caption='[[6j7s]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6J7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6j7s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6J7S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6j7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7s OCA], [http://pdbe.org/6j7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j7s RCSB], [http://www.ebi.ac.uk/pdbsum/6j7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7s ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6j7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7s OCA], [http://pdbe.org/6j7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j7s RCSB], [http://www.ebi.ac.uk/pdbsum/6j7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7s ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis (Mtb) encodes an exceptionally large number of toxin-antitoxin (TA) systems, supporting the hypothesis that TA systems are involved in pathogenesis. We characterized the putative Mtb Rv1044-Rv1045 TA locus structurally and functionally, demonstrating that it constitutes a bona fide TA system but adopts a previously unobserved antitoxicity mechanism involving phosphorylation of the toxin. While Rv1045 encodes the guanylyltransferase TglT functioning as a toxin, Rv1044 encodes the novel atypical serine protein kinase TakA, which specifically phosphorylates the cognate toxin at residue S78, thereby neutralizing its toxicity. In contrast to previous predictions, we found that Rv1044-Rv1045 does not belong to the type IV TA family because TglT and TakA interact with each other as substrate and kinase, suggesting an unusual type of TA system. Protein homology analysis suggests that other COG5340-DUF1814 protein pairs, two highly associated but uncharacterized protein families widespread in prokaryotes, might share this unusual antitoxicity mechanism.
		+
		+	Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.,Yu X, Gao X, Zhu K, Yin H, Mao X, Wojdyla JA, Qin B, Huang H, Wang M, Sun YC, Cui S Commun Biol. 2020 May 7;3(1):216. doi: 10.1038/s42003-020-0941-1. PMID:32382148<ref>PMID:32382148</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6j7s" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cui S]]	+	[[Category: Cui, S]]
-	[[Category: Gao X]]	+	[[Category: Gao, X]]
-	[[Category: Wang M]]	+	[[Category: Wang, M]]
-	[[Category: Wojdyla JA]]	+	[[Category: Wojdyla, J A]]
-	[[Category: Yu X]]	+	[[Category: Yu, X]]
-	[[Category: Zhu K]]	+	[[Category: Zhu, K]]
		+	[[Category: Guanylyltransferase]]
		+	[[Category: Guanylyltransferase-like toxin]]
		+	[[Category: Ta]]
		+	[[Category: Toxin]]

OCA at 05:22, 13 May 2020

2020-05-13T05:22:46Z

←Older revision		Revision as of 05:22, 13 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6j7s ~~is ON HOLD until Jul 18 2021~~	+	==Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis==
-		+	<StructureSection load='6j7s' size='340' side='right'caption='[[6j7s]]' scene=''>
-	~~Authors~~: ~~Gao~~, X., Yu, X., ~~Zhu, K~~., ~~Cui, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6J7S FirstGlance]. <br>
-	~~Description: Structure of the bacterial pathogens GTPase wild type~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6j7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7s OCA], [http://pdbe.org/6j7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j7s RCSB], [http://www.ebi.ac.uk/pdbsum/6j7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7s ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Yu, X~~]]	+	__TOC__
-	[[Category: Gao, X]]	+	</StructureSection>
-	[[Category: ~~Zhu, K~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Cui, S~~]]	+	[[Category: Cui S]]
		+	[[Category: Gao X]]
		+	[[Category: Wang M]]
		+	[[Category: Wojdyla JA]]
		+	[[Category: Yu X]]
		+	[[Category: Zhu K]]

OCA at 05:24, 4 March 2020

2020-03-04T05:24:59Z

←Older revision		Revision as of 05:24, 4 March 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j7s is ON HOLD until ~~Mar 25~~ 2021	+	The entry 6j7s is ON HOLD until Jul 18 2021

	Authors: Gao, X., Yu, X., Zhu, K., Cui, S.		Authors: Gao, X., Yu, X., Zhu, K., Cui, S.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yu, X]]		[[Category: Yu, X]]
-	[[Category: Zhu, K]]
	[[Category: Gao, X]]		[[Category: Gao, X]]
		+	[[Category: Zhu, K]]
	[[Category: Cui, S]]		[[Category: Cui, S]]

OCA at 06:28, 1 January 2020

2020-01-01T06:28:47Z

←Older revision		Revision as of 06:28, 1 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j7s is ON HOLD until ~~Feb 26~~ 2021	+	The entry 6j7s is ON HOLD until Mar 25 2021

	Authors: Gao, X., Yu, X., Zhu, K., Cui, S.		Authors: Gao, X., Yu, X., Zhu, K., Cui, S.

OCA at 04:59, 27 November 2019

2019-11-27T04:59:53Z

←Older revision		Revision as of 04:59, 27 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j7s is ON HOLD until ~~Paper Publication~~	+	The entry 6j7s is ON HOLD until Feb 26 2021

	Authors: Gao, X., Yu, X., Zhu, K., Cui, S.		Authors: Gao, X., Yu, X., Zhu, K., Cui, S.

OCA at 13:31, 27 February 2019

2019-02-27T13:31:31Z

←Older revision		Revision as of 13:31, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6j7s is ON HOLD	+	The entry 6j7s is ON HOLD until Paper Publication

	Authors: Gao, X., Yu, X., Zhu, K., Cui, S.		Authors: Gao, X., Yu, X., Zhu, K., Cui, S.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yu, X]]		[[Category: Yu, X]]
-	[[Category: Gao, X]]
	[[Category: Zhu, K]]		[[Category: Zhu, K]]
		+	[[Category: Gao, X]]
	[[Category: Cui, S]]		[[Category: Cui, S]]

OCA: Protected "6j7s" [edit=sysop:move=sysop]

2019-01-30T06:12:44Z

Protected "6j7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6j7s is ON HOLD Authors: Gao, X., Yu, X., Zhu, K., Cui, S. Description: Structure of the bacterial pathogens GTPase wild type [[Category: Unrelease...

2019-01-30T06:12:42Z

New page: '''Unreleased structure''' The entry 6j7s is ON HOLD Authors: Gao, X., Yu, X., Zhu, K., Cui, S. Description: Structure of the bacterial pathogens GTPase wild type [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 6j7s is ON HOLD

Authors: Gao, X., Yu, X., Zhu, K., Cui, S.

Description: Structure of the bacterial pathogens GTPase wild type
[[Category: Unreleased Structures]]
[[Category: Yu, X]]
[[Category: Gao, X]]
[[Category: Zhu, K]]
[[Category: Cui, S]]