6jze - Revision history

OCA at 06:35, 7 April 2023

2023-04-07T06:35:27Z

←Older revision		Revision as of 06:35, 7 April 2023
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	<StructureSection load='6jze' size='340' side='right'caption='[[6jze]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='6jze' size='340' side='right'caption='[[6jze]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JZE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase Tubulinyl-Tyr carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.17 3.4.17.17] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jze OCA], [https://pdbe.org/6jze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jze RCSB], [https://www.ebi.ac.uk/pdbsum/6jze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jze ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jze OCA], [~~http~~://pdbe.org/6jze PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jze RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jze PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jze ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/VASH2_MOUSE VASH2_MOUSE]] Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).<ref>PMID:19204325</ref> <ref>PMID:29146868</ref> [[http://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN]] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>	+	[https://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6jze" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6jze" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carboxypeptidase 3D structures\|Carboxypeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tubulinyl-Tyr carboxypeptidase~~]]	+	[[Category: Mus musculus]]
-	[[Category: Chen, Z]]	+	[[Category: Chen Z]]
-	[[Category: Ling, Y]]	+	[[Category: Ling Y]]
-	[[Category: Zeyuan, G]]	+	[[Category: Zeyuan G]]
-	[[Category: Zhu, L]]	+	[[Category: Zhu L]]
-	~~[[Category: Cytosolic protein]]~~	+
-	~~[[Category: Svbp]]~~	+
-	~~[[Category: Tubulin detyrosination]]~~	+
-	~~[[Category: Vash2~~]]	+

OCA at 05:51, 7 August 2019

2019-08-07T05:51:54Z

←Older revision		Revision as of 05:51, 7 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6jze is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of VASH2-SVBP complex with the magic triangle I3C==
		+	<StructureSection load='6jze' size='340' side='right'caption='[[6jze]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6jze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JZE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase Tubulinyl-Tyr carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.17 3.4.17.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jze OCA], [http://pdbe.org/6jze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jze RCSB], [http://www.ebi.ac.uk/pdbsum/6jze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jze ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VASH2_MOUSE VASH2_MOUSE]] Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).<ref>PMID:19204325</ref> <ref>PMID:29146868</ref> [[http://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN]] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The C-terminus of alpha-tubulin undergoes a detyrosination/tyrosination cycle and dysregulation of this cycle is associated with cancer and other diseases. The molecular mechanisms of tubulin tyrosination are well studied, however it has remained unknown how tyrosine is cleaved from the tubulin tail. Here, we report the crystal structure of the long-sought detyrosination enzyme, the VASH2/SVBP heterodimer at 2.2 A resolution and the structure of the tail/VASH2/SVBP complex at 2.5 A resolution. VASH2 possesses a non-canonical Cys-His-Ser catalytic architecture for tyrosine cleavage. The dynamics of the alpha1- and alpha2- helices of VASH2 are related to the insolubility of VASH2. SVBP plays a chaperone-like role by extensively interacting with VASH2 and stabilizing these dynamic helices. A positively charged groove around the catalytic pocket and the alpha1- and alpha2- helices of VASH2 targets the tubulin tail for detyrosination. We provide insights into the mechanisms underlying the cycle of tubulin tyrosine cleavage and religation.

-	~~Authors~~:	+	Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.,Zhou C, Yan L, Zhang WH, Liu Z Nat Commun. 2019 Jul 19;10(1):3212. doi: 10.1038/s41467-019-11277-8. PMID:31324789<ref>PMID:31324789</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6jze" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tubulinyl-Tyr carboxypeptidase]]
		+	[[Category: Chen, Z]]
		+	[[Category: Ling, Y]]
		+	[[Category: Zeyuan, G]]
		+	[[Category: Zhu, L]]
		+	[[Category: Cytosolic protein]]
		+	[[Category: Svbp]]
		+	[[Category: Tubulin detyrosination]]
		+	[[Category: Vash2]]

OCA at 04:32, 31 July 2019

2019-07-31T04:32:19Z

←Older revision		Revision as of 04:32, 31 July 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jze is ON HOLD	+	The entry 6jze is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6jze" [edit=sysop:move=sysop]

2019-05-10T07:40:14Z

Protected "6jze" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:40, 10 May 2019

OCA: New page: '''Unreleased structure''' The entry 6jze is ON HOLD Authors: Description: Category: Unreleased Structures

2019-05-10T07:40:12Z

New page: '''Unreleased structure''' The entry 6jze is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jze is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]