6k3b - Revision history

OCA at 10:26, 22 November 2023

2023-11-22T10:26:09Z

←Older revision		Revision as of 10:26, 22 November 2023
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	<StructureSection load='6k3b' size='340' side='right'caption='[[6k3b]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='6k3b' size='340' side='right'caption='[[6k3b]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k3b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_33152 Atcc 33152~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6K3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k3b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K3B FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>C3927_10720 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~446 ATCC 33152])~~, ~~C3928_10970 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=446 ATCC 33152])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.974Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6k3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3b OCA], [~~http~~://pdbe.org/6k3b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k3b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k3b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3b OCA], [https://pdbe.org/6k3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k3b RCSB], [https://www.ebi.ac.uk/pdbsum/6k3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3b ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5ZTL4_LEGPH Q5ZTL4_LEGPH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 33152]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Feng, Y]]	+	[[Category: Legionella pneumophila]]
-	[[Category: Han, Y]]	+	[[Category: Feng Y]]
-	[[Category: Li, D]]	+	[[Category: Han Y]]
-	[[Category: Mu, Y]]	+	[[Category: Li D]]
-	[[Category: Wang, Y]]	+	[[Category: Mu Y]]
-	~~[[Category: Antitoxin]]~~	+	[[Category: Wang Y]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Deamidase]]~~	+
-	~~[[Category: Metaeffector~~]]	+

OCA at 07:11, 27 May 2020

2020-05-27T07:11:10Z

←Older revision		Revision as of 07:11, 27 May 2020
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	<StructureSection load='6k3b' size='340' side='right'caption='[[6k3b]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='6k3b' size='340' side='right'caption='[[6k3b]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k3b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3B OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6K3B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3b OCA], [http://pdbe.org/6k3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k3b RCSB], [http://www.ebi.ac.uk/pdbsum/6k3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3b ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C3927_10720 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152]), C3928_10970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6k3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3b OCA], [http://pdbe.org/6k3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k3b RCSB], [http://www.ebi.ac.uk/pdbsum/6k3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3b ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, the Legionella effector MavC was found to mediate a unique ubiquitination through transglutamination, linking ubiquitin (Ub) to UBE2N through Ub(Gln40) in a process that can be inhibited by another Legionella effector, Lpg2149. Here, we report the structures of MavC/UBE2N/Ub ternary complex, MavC/UBE2N-Ub (product) binary complex, and MavC/Lpg2149 binary complex. During the ubiquitination, the loop containing the modification site K92 of UBE2N undergoes marked conformational change, and Lpg2149 inhibits this ubiquitination through competing with Ub to bind MavC. Moreover, we found that MavC itself also exhibits weak deubiquitinase activity towards this non-canonical ubiquitination. Together, our study not only provides insights into the mechanism and inhibition of this transglutaminase-induced ubiquitination by MavC, but also sheds light on the future studies into UBE2N inhibition by this modification and deubiquitinases of this unique ubiquitination.
		+
		+	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.,Mu Y, Wang Y, Huang Y, Li D, Han Y, Chang M, Fu J, Xie Y, Ren J, Wang H, Zhang Y, Luo ZQ, Feng Y Nat Commun. 2020 Apr 14;11(1):1774. doi: 10.1038/s41467-020-15645-7. PMID:32286321<ref>PMID:32286321</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6k3b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 33152]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Feng, Y]]		[[Category: Feng, Y]]

OCA at 09:06, 1 April 2020

2020-04-01T09:06:44Z

←Older revision		Revision as of 09:06, 1 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6k3b is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Lpg2147-Lpg2149 complex==
-		+	<StructureSection load='6k3b' size='340' side='right'caption='[[6k3b]], [[Resolution\|resolution]] 1.97Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6k3b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K3B FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3b OCA], [http://pdbe.org/6k3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k3b RCSB], [http://www.ebi.ac.uk/pdbsum/6k3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3b ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Feng, Y]]
		+	[[Category: Han, Y]]
		+	[[Category: Li, D]]
		+	[[Category: Mu, Y]]
		+	[[Category: Wang, Y]]
		+	[[Category: Antitoxin]]
		+	[[Category: Complex]]
		+	[[Category: Deamidase]]
		+	[[Category: Metaeffector]]

OCA at 20:58, 5 June 2019

2019-06-05T20:58:07Z

←Older revision		Revision as of 20:58, 5 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6k3b is ON HOLD	+	The entry 6k3b is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6k3b" [edit=sysop:move=sysop]

2019-05-22T03:57:41Z

Protected "6k3b" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:57, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6k3b is ON HOLD Authors: Description: Category: Unreleased Structures

2019-05-22T03:57:39Z

New page: '''Unreleased structure''' The entry 6k3b is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6k3b is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]