6k9y - Revision history

OCA at 10:28, 22 November 2023

2023-11-22T10:28:34Z

←Older revision		Revision as of 10:28, 22 November 2023
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	<StructureSection load='6k9y' size='340' side='right'caption='[[6k9y]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6k9y' size='340' side='right'caption='[[6k9y]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k9y]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K9Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k9y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K9Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NO3:NITRATE+ION'>NO3</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~VAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k9y OCA], [~~http~~://pdbe.org/6k9y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k9y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k9y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k9y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k9y OCA], [https://pdbe.org/6k9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k9y RCSB], [https://www.ebi.ac.uk/pdbsum/6k9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k9y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VAT1_HUMAN VAT1_HUMAN]] Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).<ref>PMID:12898150</ref> <ref>PMID:17105775</ref> <ref>PMID:19508442</ref>	+	[https://www.uniprot.org/uniprot/VAT1_HUMAN VAT1_HUMAN] Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).<ref>PMID:12898150</ref> <ref>PMID:17105775</ref> <ref>PMID:19508442</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Endo, T]]	+	[[Category: Endo T]]
-	[[Category: Watanabe, Y]]	+	[[Category: Watanabe Y]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Phospholipid transfer protein~~]]	+

OCA at 10:13, 18 March 2020

2020-03-18T10:13:30Z

←Older revision		Revision as of 10:13, 18 March 2020
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	<StructureSection load='6k9y' size='340' side='right'caption='[[6k9y]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6k9y' size='340' side='right'caption='[[6k9y]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k9y]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k9y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K9Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k9y OCA], [http://pdbe.org/6k9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k9y RCSB], [http://www.ebi.ac.uk/pdbsum/6k9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k9y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k9y OCA], [http://pdbe.org/6k9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k9y RCSB], [http://www.ebi.ac.uk/pdbsum/6k9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k9y ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Endo, T]]		[[Category: Endo, T]]

OCA at 04:11, 13 February 2020

2020-02-13T04:11:25Z

←Older revision		Revision as of 04:11, 13 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6k9y is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of human VAT-1==
		+	<StructureSection load='6k9y' size='340' side='right'caption='[[6k9y]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6k9y]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K9Y FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k9y OCA], [http://pdbe.org/6k9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k9y RCSB], [http://www.ebi.ac.uk/pdbsum/6k9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k9y ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VAT1_HUMAN VAT1_HUMAN]] Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).<ref>PMID:12898150</ref> <ref>PMID:17105775</ref> <ref>PMID:19508442</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eukaryotic cells are compartmentalized to form organelles, whose functions rely on proper phospholipid and protein transport. Here we determined the crystal structure of human VAT-1, a cytosolic soluble protein that was suggested to transfer phosphatidylserine, at 2.2 A resolution. We found that VAT-1 transferred not only phosphatidylserine but also other acidic phospholipids between membranes in vitro. Structure-based mutational analyses showed the presence of a possible lipid-binding cavity at the interface between the two sub-domains, and two tyrosine residues in the flexible loops facilitated phospholipid transfer, likely by functioning as a gate to this lipid-binding cavity. We also found that a basic and hydrophobic loop with two tryptophan residues was protruded from the molecule and facilitated binding to the acidic-lipid membranes, thereby achieving efficient phospholipid transfer.

-	~~Authors~~:	+	Structural basis for inter-organelle phospholipid transport mediated by VAT-1.,Watanabe Y, Tamura Y, Kakuta C, Watanabe S, Endo T J Biol Chem. 2020 Jan 31. pii: RA119.011019. doi: 10.1074/jbc.RA119.011019. PMID:32005660<ref>PMID:32005660</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6k9y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Endo, T]]
		+	[[Category: Watanabe, Y]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Phospholipid transfer protein]]

OCA at 06:31, 2 October 2019

2019-10-02T06:31:05Z

←Older revision		Revision as of 06:31, 2 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6k9y is ON HOLD	+	The entry 6k9y is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6k9y" [edit=sysop:move=sysop]

2019-06-26T05:06:59Z

Protected "6k9y" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:06, 26 June 2019

OCA: New page: '''Unreleased structure''' The entry 6k9y is ON HOLD Authors: Description: Category: Unreleased Structures

2019-06-26T05:06:57Z

New page: '''Unreleased structure''' The entry 6k9y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6k9y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]