6kfg - Revision history

OCA at 02:23, 11 April 2020

2020-04-11T02:23:03Z

←Older revision		Revision as of 02:23, 11 April 2020
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	<SX load='6kfg' size='340' side='right' viewer='molstar' caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6kfg' size='340' side='right' viewer='molstar' caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6KFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KFG FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inx-6, opu-6, C36H8.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inx-6, opu-6, C36H8.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6kfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kfg OCA], [http://pdbe.org/6kfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kfg RCSB], [http://www.ebi.ac.uk/pdbsum/6kfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kfg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kfg OCA], [http://pdbe.org/6kfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kfg RCSB], [http://www.ebi.ac.uk/pdbsum/6kfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:52, 11 March 2020

2020-03-11T07:52:23Z

←Older revision		Revision as of 07:52, 11 March 2020
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	<SX load='6kfg' size='340' side='right' viewer='molstar' caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6kfg' size='340' side='right' viewer='molstar' caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KFG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kfg OCA], [http://pdbe.org/6kfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kfg RCSB], [http://www.ebi.ac.uk/pdbsum/6kfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kfg ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inx-6, opu-6, C36H8.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kfg OCA], [http://pdbe.org/6kfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kfg RCSB], [http://www.ebi.ac.uk/pdbsum/6kfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/INX6_CAEEL INX6_CAEEL]] Structural component of the gap junctions.[UniProtKB:O61715]		[[http://www.uniprot.org/uniprot/INX6_CAEEL INX6_CAEEL]] Structural component of the gap junctions.[UniProtKB:O61715]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gap junctions form intercellular conduits with a large pore size whose closed and open states regulate communication between adjacent cells. The structural basis of the mechanism by which gap junctions close, however, remains uncertain. Here, we show the cryo-electron microscopy structures of Caenorhabditis elegans innexin-6 (INX-6) gap junction proteins in an undocked hemichannel form. In the nanodisc-reconstituted structure of the wild-type INX-6 hemichannel, flat double-layer densities obstruct the channel pore. Comparison of the hemichannel structures of a wild-type INX-6 in detergent and nanodisc-reconstituted amino-terminal deletion mutant reveals that lipid-mediated amino-terminal rearrangement and pore obstruction occur upon nanodisc reconstitution. Together with molecular dynamics simulations and electrophysiology functional assays, our results provide insight into the closure of the INX-6 hemichannel in a lipid bilayer before docking of two hemichannels.
		+
		+	Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids.,Burendei B, Shinozaki R, Watanabe M, Terada T, Tani K, Fujiyoshi Y, Oshima A Sci Adv. 2020 Feb 12;6(7):eaax3157. doi: 10.1126/sciadv.aax3157. eCollection 2020, Feb. PMID:32095518<ref>PMID:32095518</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6kfg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</SX>		</SX>
		+	[[Category: Caeel]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Burendei, B]]		[[Category: Burendei, B]]

OCA at 22:23, 6 March 2020

2020-03-06T22:23:59Z

←Older revision		Revision as of 22:23, 6 March 2020
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	==Undocked INX-6 hemichannel in detergent==		==Undocked INX-6 hemichannel in detergent==
-	<~~StructureSection~~ load='6kfg' size='340' side='right'caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<SX load='6kfg' size='340' side='right' viewer='molstar' caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KFG FirstGlance]. <br>		<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KFG FirstGlance]. <br>
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	[[http://www.uniprot.org/uniprot/INX6_CAEEL INX6_CAEEL]] Structural component of the gap junctions.[UniProtKB:O61715]		[[http://www.uniprot.org/uniprot/INX6_CAEEL INX6_CAEEL]] Structural component of the gap junctions.[UniProtKB:O61715]
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Burendei, B]]		[[Category: Burendei, B]]

OCA at 04:11, 13 February 2020

2020-02-13T04:11:49Z

←Older revision		Revision as of 04:11, 13 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6kfg ~~is ON HOLD until Paper Publication~~	+	==Undocked INX-6 hemichannel in detergent==
-		+	<StructureSection load='6kfg' size='340' side='right'caption='[[6kfg]], [[Resolution\|resolution]] 3.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6kfg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KFG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kfg OCA], [http://pdbe.org/6kfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kfg RCSB], [http://www.ebi.ac.uk/pdbsum/6kfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kfg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/INX6_CAEEL INX6_CAEEL]] Structural component of the gap junctions.[UniProtKB:O61715]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Burendei, B]]
		+	[[Category: Fujiyoshi, Y]]
		+	[[Category: Oshima, A]]
		+	[[Category: Shinozaki, R]]
		+	[[Category: Tani, K]]
		+	[[Category: Terada, T]]
		+	[[Category: Watanabe, M]]
		+	[[Category: Gap junction]]
		+	[[Category: Innexin]]
		+	[[Category: Transport protein]]

OCA at 04:58, 6 November 2019

2019-11-06T04:58:40Z

←Older revision		Revision as of 04:58, 6 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kfg is ON HOLD	+	The entry 6kfg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6kfg" [edit=sysop:move=sysop]

2019-07-17T08:44:11Z

Protected "6kfg" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 17 July 2019

OCA: New page: '''Unreleased structure''' The entry 6kfg is ON HOLD Authors: Description: Category: Unreleased Structures

2019-07-17T08:44:09Z

New page: '''Unreleased structure''' The entry 6kfg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6kfg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]