6kpg - Revision history

OCA at 02:29, 11 April 2020

2020-04-11T02:29:34Z

←Older revision		Revision as of 02:29, 11 April 2020
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	<SX load='6kpg' size='340' side='right' viewer='molstar' caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6kpg' size='340' side='right' viewer='molstar' caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6KPG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KPG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8D0:(6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol'>8D0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8D0:(6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol'>8D0</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6kpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kpg OCA], [http://pdbe.org/6kpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kpg RCSB], [http://www.ebi.ac.uk/pdbsum/6kpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kpg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kpg OCA], [http://pdbe.org/6kpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kpg RCSB], [http://www.ebi.ac.uk/pdbsum/6kpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kpg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:54, 11 March 2020

2020-03-11T07:54:01Z

←Older revision		Revision as of 07:54, 11 March 2020
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	<SX load='6kpg' size='340' side='right' viewer='molstar' caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6kpg' size='340' side='right' viewer='molstar' caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KPG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KPG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8D0:(6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol'>8D0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8D0:(6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol'>8D0</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kpg OCA], [http://pdbe.org/6kpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kpg RCSB], [http://www.ebi.ac.uk/pdbsum/6kpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kpg OCA], [http://pdbe.org/6kpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kpg RCSB], [http://www.ebi.ac.uk/pdbsum/6kpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kpg ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</SX>		</SX>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hua, T]]		[[Category: Hua, T]]

OCA at 22:27, 6 March 2020

2020-03-06T22:27:09Z

←Older revision		Revision as of 22:27, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of CB1-G protein complex==		==Cryo-EM structure of CB1-G protein complex==
-	<~~StructureSection~~ load='6kpg' size='340' side='right'caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<SX load='6kpg' size='340' side='right' viewer='molstar' caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KPG FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 6kpg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6kpg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transducin 3D structures\|Transducin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hua, T]]		[[Category: Hua, T]]

OCA at 04:14, 13 February 2020

2020-02-13T04:14:08Z

←Older revision		Revision as of 04:14, 13 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6kpg is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Cryo-EM structure of CB1-G protein complex==
		+	<StructureSection load='6kpg' size='340' side='right'caption='[[6kpg]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6kpg]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KPG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8D0:(6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol'>8D0</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kpg OCA], [http://pdbe.org/6kpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kpg RCSB], [http://www.ebi.ac.uk/pdbsum/6kpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kpg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN]] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref> [[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors CB1 and CB2. Their high sequence similarity, low agonist selectivity, and lack of activation and G protein-coupling knowledge have hindered the development of therapeutic applications. Importantly, missing structural information has significantly held back the development of promising CB2-selective agonist drugs for treating inflammatory and neuropathic pain without the psychoactivity of CB1. Here, we report the cryoelectron microscopy structures of synthetic cannabinoid-bound CB2 and CB1 in complex with Gi, as well as agonist-bound CB2 crystal structure. Of important scientific and therapeutic benefit, our results reveal a diverse activation and signaling mechanism, the structural basis of CB2-selective agonists design, and the unexpected interaction of cholesterol with CB1, suggestive of its endogenous allosteric modulating role.

-	~~Authors~~:	+	Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.,Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ Cell. 2020 Jan 28. pii: S0092-8674(20)30055-6. doi: 10.1016/j.cell.2020.01.008. PMID:32004463<ref>PMID:32004463</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6kpg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hua, T]]
		+	[[Category: Li, X T]]
		+	[[Category: Liu, Z J]]
		+	[[Category: Makriyannis, A]]
		+	[[Category: Shen, L]]
		+	[[Category: Wang, Y X]]
		+	[[Category: Wu, L J]]
		+	[[Category: Cryo-em]]
		+	[[Category: G protein]]
		+	[[Category: Gpcr]]
		+	[[Category: Membrane protein]]

OCA at 06:02, 5 February 2020

2020-02-05T06:02:39Z

←Older revision		Revision as of 06:02, 5 February 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kpg is ON HOLD	+	The entry 6kpg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 12:57, 29 January 2020

2020-01-29T12:57:14Z

←Older revision		Revision as of 12:57, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kpg is ON HOLD ~~until Paper Publication~~	+	The entry 6kpg is ON HOLD

	Authors:		Authors:

OCA at 06:37, 2 October 2019

2019-10-02T06:37:49Z

←Older revision		Revision as of 06:37, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kpg is ON HOLD	+	The entry 6kpg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6kpg" [edit=sysop:move=sysop]

2019-08-21T04:06:12Z

Protected "6kpg" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:06, 21 August 2019

OCA: New page: '''Unreleased structure''' The entry 6kpg is ON HOLD Authors: Description: Category: Unreleased Structures

2019-08-21T04:06:10Z

New page: '''Unreleased structure''' The entry 6kpg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6kpg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]