OCA at 10:51, 22 November 2023

2023-11-22T10:51:46Z

←Older revision		Revision as of 10:51, 22 November 2023
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-	====	+	==ARF5 Aux/IAA17 Complex==
-	<StructureSection load='6l5k' size='340' side='right'caption='[[6l5k]]' scene=''>	+	<StructureSection load='6l5k' size='340' side='right'caption='[[6l5k]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L5K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6l5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l5k OCA], [~~http~~://pdbe.org/6l5k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6l5k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6l5k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6l5k ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.91Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l5k OCA], [https://pdbe.org/6l5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l5k RCSB], [https://www.ebi.ac.uk/pdbsum/6l5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l5k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ARFE_ARATH ARFE_ARATH] Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity.<ref>PMID:12036261</ref> <ref>PMID:14973283</ref> <ref>PMID:17553903</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Auxin is a plant hormone that is central to plant growth and development from embryogenesis to senescence. Auxin signaling is mediated by auxin response transcription factors (ARFs) and Aux/IAA repressors that regulate the expression of a multitude of auxin response genes. ARF and Aux/IAA proteins assemble into homomeric and heteromeric complexes via their conserved PB1 domains. Here we report the first crystal structure of the PB1 complex between ARF5 and IAA17 of Arabidopsis thaliana, which represents the transcriptionally repressed state at low auxin levels. The PB1 domains assemble in a head-to-tail manner with a backbone arrangement similar to that of the ARF5:ARF5 PB1 complex. The ARF5:IAA17 complex, however, reveals distinct points of contact that promote the ARF5:IAA17 interaction over the ARF5:ARF5 interaction. Specifically, surface charges at the interface form salt-bridges that distinguish the homomeric and heteromeric complexes, revealing common and specific interfaces between transcriptionally repressed and derepressed states. Further, the salt-bridges can be reconfigured to switch the affinity between homomeric and heteromeric complexes in an incremental manner. The complex structure combined with quantitative binding analyses would be essential for deciphering the PB1 interaction code underlying the transcriptional regulation of auxin signaling.
		+
		+	Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.,Kim Y, Park C, Cha S, Han M, Ryu KS, Suh JY J Mol Biol. 2020 Jun 26;432(14):4010-4022. doi: 10.1016/j.jmb.2020.04.007. Epub , 2020 Apr 17. PMID:32305460<ref>PMID:32305460</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6l5k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Cha SY]]
		+	[[Category: Kim YI]]
		+	[[Category: Park CK]]
		+	[[Category: Ryu KS]]
		+	[[Category: Suh JY]]

OCA at 06:46, 2 September 2020

2020-09-02T06:46:46Z

←Older revision		Revision as of 06:46, 2 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6l5k ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6l5k' size='340' side='right'caption='[[6l5k]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l5k OCA], [http://pdbe.org/6l5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l5k RCSB], [http://www.ebi.ac.uk/pdbsum/6l5k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l5k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 13:23, 20 November 2019

2019-11-20T13:23:08Z

←Older revision		Revision as of 13:23, 20 November 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6l5k is ON HOLD	+	The entry 6l5k is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6l5k" [edit=sysop:move=sysop]

2019-10-30T07:21:51Z

Protected "6l5k" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:21, 30 October 2019

OCA: New page: '''Unreleased structure''' The entry 6l5k is ON HOLD Authors: Description: Category: Unreleased Structures

2019-10-30T07:21:49Z

New page: '''Unreleased structure''' The entry 6l5k is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6l5k is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6l5k - Revision history

OCA at 10:51, 22 November 2023

OCA at 06:46, 2 September 2020

OCA at 13:23, 20 November 2019

OCA: Protected "6l5k" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6l5k is ON HOLD Authors: Description: Category: Unreleased Structures