OCA at 10:54, 22 November 2023

2023-11-22T10:54:08Z

←Older revision		Revision as of 10:54, 22 November 2023
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-	====	+	==349 bp di-nucleosome harboring cohesive DNA termini assembled with linker histone H1.0 (high cryoprotectant)==
-	<StructureSection load='6la9' size='340' side='right'caption='[[6la9]]' scene=''>	+	<StructureSection load='6la9' size='340' side='right'caption='[[6la9]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6la9]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Other_sequences Other sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LA9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6la9 OCA], [~~http~~://pdbe.org/6la9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6la9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6la9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6la9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6la9 OCA], [https://pdbe.org/6la9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6la9 RCSB], [https://www.ebi.ac.uk/pdbsum/6la9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6la9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chromosome structure at the multi-nucleosomal level has remained ambiguous in spite of its central role in epigenetic regulation and genome dynamics. Recent investigations of chromatin architecture portray diverse modes of interaction within and between nucleosome chains, but how this is realized at the atomic level is unclear. Here we present near-atomic resolution crystal structures of nucleosome fibres that assemble from cohesive-ended dinucleosomes with and without linker histone. As opposed to adopting folded helical '30 nm' structures, the fibres instead assume open zigzag conformations that are interdigitated with one another. Zigzag conformations obviate extreme bending of the linker DNA, while linker DNA size (nucleosome repeat length) dictates fibre configuration and thus fibre-fibre packing, which is supported by variable linker histone binding. This suggests that nucleosome chains have a predisposition to interdigitate with specific characteristics under condensing conditions, which rationalizes observations of local chromosome architecture and the general heterogeneity of chromatin structure.
		+
		+	Near-atomic resolution structures of interdigitated nucleosome fibres.,Adhireksan Z, Sharma D, Lee PL, Davey CA Nat Commun. 2020 Sep 21;11(1):4747. doi: 10.1038/s41467-020-18533-2. PMID:32958761<ref>PMID:32958761</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6la9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone 3D structures\|Histone 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Other sequences]]
		+	[[Category: Adhireksan Z]]
		+	[[Category: Davey CA]]
		+	[[Category: Lee PL]]
		+	[[Category: Sharma D]]

OCA at 06:15, 7 October 2020

2020-10-07T06:15:59Z

←Older revision		Revision as of 06:15, 7 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6la9 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6la9' size='340' side='right'caption='[[6la9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6la9 OCA], [http://pdbe.org/6la9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6la9 RCSB], [http://www.ebi.ac.uk/pdbsum/6la9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6la9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:36, 18 December 2019

2019-12-18T05:36:18Z

←Older revision		Revision as of 05:36, 18 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6la9 is ON HOLD	+	The entry 6la9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6la9" [edit=sysop:move=sysop]

2019-11-20T13:27:48Z

Protected "6la9" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:27, 20 November 2019

OCA: New page: '''Unreleased structure''' The entry 6la9 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-11-20T13:27:46Z

New page: '''Unreleased structure''' The entry 6la9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6la9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6la9 - Revision history

OCA at 10:54, 22 November 2023

OCA at 06:15, 7 October 2020

OCA at 05:36, 18 December 2019

OCA: Protected "6la9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6la9 is ON HOLD Authors: Description: Category: Unreleased Structures