6lcy - Revision history

OCA at 10:57, 22 November 2023

2023-11-22T10:57:07Z

←Older revision		Revision as of 10:57, 22 November 2023
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	<StructureSection load='6lcy' size='340' side='right'caption='[[6lcy]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6lcy' size='340' side='right'caption='[[6lcy]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LCY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LCY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.301Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Syt7 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lcy OCA], [https://pdbe.org/6lcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lcy RCSB], [https://www.ebi.ac.uk/pdbsum/6lcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lcy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lcy OCA], [https://pdbe.org/6lcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lcy RCSB], [https://www.ebi.ac.uk/pdbsum/6lcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lcy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SYT7_MOUSE SYT7_MOUSE]] May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity).	+	[https://www.uniprot.org/uniprot/SYT7_MOUSE SYT7_MOUSE] May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Rao, F]]	+	[[Category: Rao F]]
-	[[Category: Wang, C]]	+	[[Category: Wang C]]
-	[[Category: Zhang, X]]	+	[[Category: Zhang X]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Exocytosis]]~~	+
-	~~[[Category: Insulin secretion]]~~	+
-	~~[[Category: Ip6]]~~	+
-	~~[[Category: Synaptotagmin-7~~]]	+

OCA at 14:07, 17 November 2021

2021-11-17T14:07:16Z

←Older revision		Revision as of 14:07, 17 November 2021
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	==Crystal structure of Synaptotagmin-7 C2B in complex with IP6==		==Crystal structure of Synaptotagmin-7 C2B in complex with IP6==
-	<StructureSection load='6lcy' size='340' side='right'caption='[[6lcy]]' scene=''>	+	<StructureSection load='6lcy' size='340' side='right'caption='[[6lcy]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LCY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LCY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lcy OCA], [https://pdbe.org/6lcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lcy RCSB], [https://www.ebi.ac.uk/pdbsum/6lcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lcy ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Syt7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lcy OCA], [https://pdbe.org/6lcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lcy RCSB], [https://www.ebi.ac.uk/pdbsum/6lcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lcy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SYT7_MOUSE SYT7_MOUSE]] May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	5-diphosphoinositol pentakisphosphate (5-IP7) is a signalling metabolite linked to various cellular processes. How extracellular stimuli elicit 5-IP7 signalling remains unclear. Here we show that 5-IP7 in beta cells mediates parasympathetic stimulation of synaptotagmin-7 (Syt7)-dependent insulin release. Mechanistically, vagal stimulation and activation of muscarinic acetylcholine receptors triggers Galphaq-PLC-PKC-PKD-dependent signalling and activates IP6K1, the 5-IP7 synthase. Whereas both 5-IP7 and its precursor IP6 compete with PIP2 for binding to Syt7, Ca(2+) selectively binds 5-IP7 with high affinity, freeing Syt7 to enable fusion of insulin-containing vesicles with the cell membrane. beta-cell-specific IP6K1 deletion diminishes insulin secretion and glucose clearance elicited by muscarinic stimulation, whereas mice carrying a phosphorylation-mimicking, hyperactive IP6K1 mutant display augmented insulin release, congenital hyperinsulinaemia and obesity. These phenotypes are absent in mice lacking Syt7. Our study proposes a new conceptual framework for inositol pyrophosphate physiology in which 5-IP7 acts as a GPCR second messenger at the interface between peripheral nervous system and metabolic organs, transmitting Gq-coupled GPCR stimulation to unclamp Syt7-dependent, and perhaps other, exocytotic events.
		+
		+	5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis.,Zhang X, Li N, Zhang J, Zhang Y, Yang X, Luo Y, Zhang B, Xu Z, Zhu Z, Yang X, Yan Y, Lin B, Wang S, Chen D, Ye C, Ding Y, Lou M, Wu Q, Hou Z, Zhang K, Liang Z, Wei A, Wang B, Wang C, Jiang N, Zhang W, Xiao G, Ma C, Ren Y, Qi X, Han W, Wang C, Rao F Nat Metab. 2021 Oct;3(10):1400-1414. doi: 10.1038/s42255-021-00468-7. Epub 2021, Oct 18. PMID:34663975<ref>PMID:34663975</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lcy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rao F]]	+	[[Category: Lk3 transgenic mice]]
-	[[Category: Wang C]]	+	[[Category: Rao, F]]
-	[[Category: Zhang X]]	+	[[Category: Wang, C]]
-	[[Category: Zhang Y]]	+	[[Category: Zhang, X]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Exocytosis]]
		+	[[Category: Insulin secretion]]
		+	[[Category: Ip6]]
		+	[[Category: Synaptotagmin-7]]

OCA at 14:40, 3 March 2021

2021-03-03T14:40:58Z

←Older revision		Revision as of 14:40, 3 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6lcy is ~~ON HOLD until Mar 02 2022~~	+	==Crystal structure of Synaptotagmin-7 C2B in complex with IP6==
-		+	<StructureSection load='6lcy' size='340' side='right'caption='[[6lcy]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LCY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lcy OCA], [https://pdbe.org/6lcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lcy RCSB], [https://www.ebi.ac.uk/pdbsum/6lcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lcy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rao F]]
		+	[[Category: Wang C]]
		+	[[Category: Zhang X]]
		+	[[Category: Zhang Y]]

OCA at 05:25, 2 December 2020

2020-12-02T05:25:11Z

←Older revision		Revision as of 05:25, 2 December 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lcy is ON HOLD until ~~Paper Publication~~	+	The entry 6lcy is ON HOLD until Mar 02 2022

	Authors:		Authors:

OCA at 12:57, 29 January 2020

2020-01-29T12:57:50Z

←Older revision		Revision as of 12:57, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lcy is ON HOLD	+	The entry 6lcy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6lcy" [edit=sysop:move=sysop]

2019-11-27T05:07:48Z

Protected "6lcy" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:07, 27 November 2019

OCA: New page: '''Unreleased structure''' The entry 6lcy is ON HOLD Authors: Description: Category: Unreleased Structures

2019-11-27T05:07:46Z

New page: '''Unreleased structure''' The entry 6lcy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lcy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]