OCA at 14:40, 29 November 2023

2023-11-29T14:40:45Z

←Older revision		Revision as of 14:40, 29 November 2023
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	==crystal structure of alpha-momorcharin in complex with xanthosine==		==crystal structure of alpha-momorcharin in complex with xanthosine==
-	<StructureSection load='6lov' size='340' side='right'caption='[[6lov]]' scene=''>	+	<StructureSection load='6lov' size='340' side='right'caption='[[6lov]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LOV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lov OCA], [~~http~~://pdbe.org/6lov PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lov RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lov PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lov ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UO:2,3-DIHYDROXANTHOSINE'>4UO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lov OCA], [https://pdbe.org/6lov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lov RCSB], [https://www.ebi.ac.uk/pdbsum/6lov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lov ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RIP1_MOMCH RIP1_MOMCH]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Alpha-momorcharin (Alpha-MMC) from the seed of bitter melon is a type I ribosome inactivating protein (RIP) that removes a specific adenine from 28S rRNA and inhibits protein biosynthesis. Here, we report seven crystal complex structures of alpha-MMC with different substrate analogs (adenine, AMP, cAMP, dAMP, ADP, GMP, and xanthosine) at 1.08 A to 1.52 A resolution. These structures reveal that not only adenine, but also guanine and their analogs can effectively bind to alpha-MMC. The side chain of Tyr93 adopts two conformations, serving as a switch to open and close the substrate binding pocket of alpha-MMC. Although adenine, AMP, GMP, and guanine are located in a similar active site in different RIPs, residues involved in the interaction between RIPs and substrate analogs are slightly different. Complex structures of alpha-MMC with different substrate analogs solved in this study provide useful information on its enzymatic mechanisms and may enable the development of new inhibitors to treat the poisoning of alpha-MMC.
		+
		+	Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs.,Fan X, Wang Y, Guo F, Zhang Y, Jin T Int J Biol Macromol. 2020 Dec 1;164:265-276. doi: 10.1016/j.ijbiomac.2020.07.063., Epub 2020 Jul 10. PMID:32653369<ref>PMID:32653369</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lov" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome inactivating protein 3D structures\|Ribosome inactivating protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Momordica charantia]]
	[[Category: Fan X]]		[[Category: Fan X]]
	[[Category: Jin T]]		[[Category: Jin T]]

OCA at 09:32, 18 November 2020

2020-11-18T09:32:06Z

←Older revision		Revision as of 09:32, 18 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lov ~~is ON HOLD until Paper Publication~~	+	==crystal structure of alpha-momorcharin in complex with xanthosine==
-		+	<StructureSection load='6lov' size='340' side='right'caption='[[6lov]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LOV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lov OCA], [http://pdbe.org/6lov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lov RCSB], [http://www.ebi.ac.uk/pdbsum/6lov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lov ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fan X]]
		+	[[Category: Jin T]]

OCA at 13:00, 29 January 2020

2020-01-29T13:00:52Z

←Older revision		Revision as of 13:00, 29 January 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lov is ON HOLD	+	The entry 6lov is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6lov" [edit=sysop:move=sysop]

2020-01-22T13:34:42Z

Protected "6lov" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:34, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6lov is ON HOLD Authors: Description: Category: Unreleased Structures

2020-01-22T13:34:39Z

New page: '''Unreleased structure''' The entry 6lov is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lov is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6lov - Revision history

OCA at 14:40, 29 November 2023

OCA at 09:32, 18 November 2020

OCA at 13:00, 29 January 2020

OCA: Protected "6lov" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6lov is ON HOLD Authors: Description: Category: Unreleased Structures